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O25516 (THIM_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:HP_0845
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence AAD07891.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156937

Sites

Binding site371Substrate; via amide nitrogen By similarity
Binding site1131ATP By similarity
Binding site1581ATP By similarity
Binding site1851Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O25516 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: ACC0DCE9B993F730

FASTA25927,515
        10         20         30         40         50         60 
MLKELRQKRP LVHNITNYVA AQFVANGLLA LGASPLMSDA IDEMRDLAKI SDALAINIGT 

        70         80         90        100        110        120 
LNDRAILCAK EAIKHYKALN KPIVLDPVGC SASALRHDTS LELLKSGGIS ALRGNAAELG 

       130        140        150        160        170        180 
SLVGISCESK GLDSNDAATP VEIIKLAAQK YSVIAVMTGK TDYVSDGKKV LSITGGSEYL 

       190        200        210        220        230        240 
ALITGAGCLH AAACASFLSL KKDPLDSMAQ LCALYKQAAF NAQKKVLENN GSNGSFLFYF 

       250 
LDALSLPIEL ENSLIKEEW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07891.1. Different initiation.
PIRE64625.
RefSeqNP_207638.1. NC_000915.1.
YP_006934759.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO25516. 1 interaction.
STRING85962.HP0845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07891; AAD07891; HP_0845.
GeneID899374.
KEGGheo:C694_04330.
hpy:HP0845.
PATRIC20592983. VBIHelPyl33062_0879.

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMAGAFCAVQ.
OrthoDBEOG628F8M.

Enzyme and pathway databases

UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_HELPY
AccessionPrimary (citable) accession number: O25516
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names