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O25516

- THIM_HELPY

UniProt

O25516 - THIM_HELPY

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, HP_0845
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate; via amide nitrogen By similarity
Binding sitei113 – 1131ATP By similarity
Binding sitei158 – 1581ATP By similarity
Binding sitei185 – 1851Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:HP_0845
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000156937Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO25516. 1 interaction.
STRINGi85962.HP0845.

Structurei

3D structure databases

ProteinModelPortaliO25516.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
KOiK00878.
OMAiGAFCAVQ.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

O25516-1 [UniParc]FASTAAdd to Basket

« Hide

MLKELRQKRP LVHNITNYVA AQFVANGLLA LGASPLMSDA IDEMRDLAKI    50
SDALAINIGT LNDRAILCAK EAIKHYKALN KPIVLDPVGC SASALRHDTS 100
LELLKSGGIS ALRGNAAELG SLVGISCESK GLDSNDAATP VEIIKLAAQK 150
YSVIAVMTGK TDYVSDGKKV LSITGGSEYL ALITGAGCLH AAACASFLSL 200
KKDPLDSMAQ LCALYKQAAF NAQKKVLENN GSNGSFLFYF LDALSLPIEL 250
ENSLIKEEW 259
Length:259
Mass (Da):27,515
Last modified:December 1, 2000 - v2
Checksum:iACC0DCE9B993F730
GO

Sequence cautioni

The sequence AAD07891.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07891.1. Different initiation.
PIRiE64625.
RefSeqiNP_207638.1. NC_000915.1.
YP_006934759.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07891; AAD07891; HP_0845.
GeneIDi13870029.
899374.
KEGGiheo:C694_04330.
hpy:HP0845.
PATRICi20592983. VBIHelPyl33062_0879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07891.1 . Different initiation.
PIRi E64625.
RefSeqi NP_207638.1. NC_000915.1.
YP_006934759.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25516. 1 interaction.
STRINGi 85962.HP0845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07891 ; AAD07891 ; HP_0845 .
GeneIDi 13870029.
899374.
KEGGi heo:C694_04330.
hpy:HP0845.
PATRICi 20592983. VBIHelPyl33062_0879.

Phylogenomic databases

eggNOGi COG2145.
KOi K00878.
OMAi GAFCAVQ.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTHIM_HELPY
AccessioniPrimary (citable) accession number: O25516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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