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O25515 (THID_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:HP_0844
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192020

Sites

Binding site461Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O25515 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C4F99BCABBD7204E

FASTA27028,925
        10         20         30         40         50         60 
MVKIYPQVLS IAGSDSGGGS GIQADLKAFQ TLGVFGTSVI TCITAQNTQG VHGVYPLSVE 

        70         80         90        100        110        120 
SVKAQILAIR DDFSIKAFKM GALCNAQIIE CVADTLETCD FGLCVLDPVM VAKNGALLLE 

       130        140        150        160        170        180 
EEAILSLKKR LLPTTHLLTP NLPEVYALTG VQVRDDKSAS KAMGVLRDLG VKNAVIKGGH 

       190        200        210        220        230        240 
TEHFQGEYSN DWVFLEDAEF ILNAKRFNTK NTHGTGCTLS SLIVGLLAQG LDLKNAISKA 

       250        260        270 
KELLTIIIQN PLNIGHGHGP LNLWSIKELV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07890.1.
PIRD64625.
RefSeqNP_207637.1. NC_000915.1.

3D structure databases

ProteinModelPortalO25515.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0844.

Proteomic databases

PRIDEO25515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07890; AAD07890; HP_0844.
GeneID899373.
KEGGhpy:HP0844.
PATRIC20592981. VBIHelPyl33062_0878.

Phylogenomic databases

eggNOGCOG0351.
KOK00941.
OMAVKTGMLW.
OrthoDBEOG6XWV53.

Enzyme and pathway databases

BioCycHPY:HP0844-MONOMER.
UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_HELPY
AccessionPrimary (citable) accession number: O25515
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names