O25502 (COAE_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	HP_0831

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00376.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Dephospho-CoA kinase HAMAP-Rule MF_00376		PRO_0000172949
Regions
	Domain	6 – 196	191	DPCK
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O25502 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FBA1CD16F8174A9F	FASTA	196	22,663
	10 20 30 40 50 60 MVLKNAIALT GGIGTGKSTT IKILESQGYK ILDADKIAHQ LLQEHRFKIA QHFGSDILEK 70 80 90 100 110 120 DILNRKKLGA IVFQDAHELK WLEDFLHPLI REHMLKKAYE LEKNHQAYFL DIPLFFEVGG 130 140 150 160 170 180 KKCYPVSKVV LVYASRALQI ERLLERDKLK EAEILQRLAC QMDIEQKRAM SDYIIDNSSS 190 LKDLNKQVER FLKTLL

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07881.1.
PIR	G64623.
RefSeq	NP_207624.1. NC_000915.1. YP_006934746.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25502.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP0831.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07881; AAD07881; HP_0831.
GeneID	13870015. 898770.
KEGG	heo:C694_04260. hpy:HP0831.
PATRIC	20592953. VBIHelPyl33062_0865.
Phylogenomic databases
eggNOG	COG0237.
KO	K00859.
OMA	QRLACQM.
ProtClustDB	PRK00081.
Enzyme and pathway databases
UniPathway	UPA00241; UER00356.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase.
InterPro	IPR001977. Depp_CoAkinase. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_HELPY

Accession

Primary (citable) accession number: O25502

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	January 1, 1998
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program