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O25484 (RIBB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase
Short name=DHBP synthase
EC=4.1.99.12
Gene names
Name:ribB
Ordered Locus Names:HP_0804
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP MF_00180

Catalytic activity

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP MF_00180

Cofactor

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. HAMAP MF_00180

Sequence similarities

In the N-terminal section; belongs to the DHBP synthase family.

In the C-terminal section; belongs to the GTP cyclohydrolase II family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3443443,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP MF_00180
PRO_0000151802

Regions

Region1 – 202202DHBP synthase HAMAP MF_00180
Region27 – 282Substrate binding By similarity
Region139 – 1435Substrate binding By similarity
Region203 – 344142GTP cyclohydrolase II-like HAMAP MF_00180

Sites

Metal binding281Magnesium or manganese 1 By similarity
Metal binding281Magnesium or manganese 2 By similarity
Metal binding1421Magnesium or manganese 2 By similarity
Binding site321Substrate By similarity
Binding site1631Substrate By similarity
Site1251Essential for catalytic activity By similarity
Site1631Essential for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
O25484 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C38382FE3DE51F64

FASTA34438,972
        10         20         30         40         50         60 
MILKRVTEAL EAYKNGEMLI VMDDEDRENE GDLVLAGIFS TPEKINFMAT HARGLICVSL 

        70         80         90        100        110        120 
TKDLAKKFEL PPMVSVNDSN HETAFTVSID AKEARTGISA FERHLTIELL CKDTTKPSDF 

       130        140        150        160        170        180 
VRPGHIFPLI AKDGGVLART GHTEASVDLC KLAGLKPVSV ICEIMKEDGS MARRGDKFLS 

       190        200        210        220        230        240 
DFALKHNLKT LYVSDLISYR LENESLLKMF CQEEREFLKH QTQCYTFLDH QQKNHYAFKF 

       250        260        270        280        290        300 
KGAKTHDLAP LVRFHPIKED FDFLTTDAFE VFFKALEYLK HEGGYLIFMN THSKENNVVK 

       310        320        330        340 
DFGIGALVLK NLGIKDFRLL SSCEDRQYKA LSGFGLKLVE TISL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07852.1.
PIRD64620.
RefSeqNP_207597.1. NC_000915.1.

3D structure databases

ProteinModelPortalO25484.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID898852.
GenomeReviewsGene locus HP_0804 in contig AE000511_GR.
KEGGhpy:HP0804.
NMPDRfig|85962.1.peg.795.
PATRIC20592895. VBIHelPyl33062_0836.
TIGRHP_0804.

Phylogenomic databases

HOGENOMHBG735778.
OMALTIELLC.
ProtClustDBPRK09314.

Family and domain databases

HAMAPMF_00180. RibB. Fused.
[Tree]
InterProIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR000926. GTP_CycHdrlaseII_RibA.
IPR016299. Riboflavin_synth_RibBA.
[Graphical view]
Gene3DG3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
KOK14652.
PfamPF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
PIRSFPIRSF001259. RibA. 1 hit.
SUPFAMSSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMsTIGR00506. RibB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIBB_HELPY
AccessionPrimary (citable) accession number: O25484
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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