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O25443

- TRMB_HELPY

UniProt

O25443 - TRMB_HELPY

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
    Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
    Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPY:HP0747-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:HP_0747
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393tRNA (guanine-N(7)-)-methyltransferasePRO_0000171335Add
    BLAST

    Proteomic databases

    PRIDEiO25443.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3501N.
    IntActiO25443. 1 interaction.
    MINTiMINT-170407.
    STRINGi85962.HP0747.

    Structurei

    3D structure databases

    ProteinModelPortaliO25443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHFLAKLDF KPLEYPLIEG DFCFHREFLS LKNPTKSCVY ASFKDRIFLL    50
    QKIRRANDFL IKSEKATPLK REVLKQALRI YSQSFEVISH NLQENSKHAS 100
    GKKTLDLGTF EDFIQKNQAP ILIEIGFGSG RHLIELAKNN PTKTCLGIEI 150
    HTPSIAQALK QIELLDLKNL HILQGDGRLV LESMPNHRCE KIFVHFPVPW 200
    NEKKHRRVLS EKFLNEALRV LKPRGFLELR TDDSLYFEDS LKLALKNFQC 250
    EIEIKKNAQI PVVSKYEARW NKLKKDIYDL RIYSLEWNET PFDNHAFDFS 300
    FDTITISKKS VGTILKTKKI IQEGYFVHVC NIYENKGDFL VELSMGDFDW 350
    PVRLFVLLTE NQIFYLNKSP LKTLNNHKAH LLLQNILSQK GIG 393
    Length:393
    Mass (Da):45,774
    Last modified:January 1, 1998 - v1
    Checksum:iC376EF02D33F71D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07796.1.
    PIRiC64613.
    RefSeqiNP_207540.1. NC_000915.1.
    YP_006934663.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07796; AAD07796; HP_0747.
    GeneIDi13869932.
    899331.
    KEGGiheo:C694_03845.
    hpy:HP0747.
    PATRICi20592783. VBIHelPyl33062_0780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07796.1 .
    PIRi C64613.
    RefSeqi NP_207540.1. NC_000915.1.
    YP_006934663.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3501N.
    IntActi O25443. 1 interaction.
    MINTi MINT-170407.
    STRINGi 85962.HP0747.

    Proteomic databases

    PRIDEi O25443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07796 ; AAD07796 ; HP_0747 .
    GeneIDi 13869932.
    899331.
    KEGGi heo:C694_03845.
    hpy:HP0747.
    PATRICi 20592783. VBIHelPyl33062_0780.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci HPY:HP0747-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiTRMB_HELPY
    AccessioniPrimary (citable) accession number: O25443
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3