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O25441

- Y745_HELPY

UniProt

O25441 - Y745_HELPY

Protein

Uncharacterized RNA pseudouridine synthase HP_0745

Gene

HP_0745

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RNA uridine = RNA pseudouridine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei136 – 1361By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0745-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized RNA pseudouridine synthase HP_0745 (EC:5.4.99.-)
    Alternative name(s):
    RNA pseudouridylate synthase
    RNA-uridine isomerase
    Gene namesi
    Ordered Locus Names:HP_0745
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Uncharacterized RNA pseudouridine synthase HP_0745PRO_0000162735Add
    BLAST

    Proteomic databases

    PRIDEiO25441.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3289N.
    IntActiO25441. 2 interactions.
    MINTiMINT-165354.
    STRINGi85962.HP0745.

    Structurei

    3D structure databases

    ProteinModelPortaliO25441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 7968S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    KOiK06180.
    OMAiLKMIALK.
    OrthoDBiEOG6P070X.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKVFIALTD HKRLDEFLAK ELQISKNQVL NLIKEGLVFC QKKEVKKGGL    50
    ALKEGDEITL LTPKITPKPL KKELDLEIEV IFEDEDLLVL NKPPNLVVHK 100
    ALSVKEPTLV DWLEFKNYEL SNLGLKERYG IVHRLDKDTS GGIVIAKNNF 150
    THVHLSEQLK TKMMGRYYIA LLSTPLKEEK MSVECYLTRN PNNRLKMIAL 200
    KAVKKEKSRY SKSEFISLLT SQNNLNLIGA KLFTGRTHQI RAHLEYLNRH 250
    IIGDNLYGLN GALPKEEIRI MLHAYLIEFK HPRSEQKLRF KVPLLKDMLE 300
    YLKKVFDKEN LDEVLDEEKI LHAFIAK 327
    Length:327
    Mass (Da):37,922
    Last modified:January 1, 1998 - v1
    Checksum:i40E7F371C9E46117
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07795.1.
    PIRiA64613.
    RefSeqiNP_207538.1. NC_000915.1.
    YP_006934661.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07795; AAD07795; HP_0745.
    GeneIDi13869930.
    898915.
    KEGGiheo:C694_03835.
    hpy:HP0745.
    PATRICi20592779. VBIHelPyl33062_0778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07795.1 .
    PIRi A64613.
    RefSeqi NP_207538.1. NC_000915.1.
    YP_006934661.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3289N.
    IntActi O25441. 2 interactions.
    MINTi MINT-165354.
    STRINGi 85962.HP0745.

    Proteomic databases

    PRIDEi O25441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07795 ; AAD07795 ; HP_0745 .
    GeneIDi 13869930.
    898915.
    KEGGi heo:C694_03835.
    hpy:HP0745.
    PATRICi 20592779. VBIHelPyl33062_0778.

    Phylogenomic databases

    eggNOGi COG0564.
    KOi K06180.
    OMAi LKMIALK.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci HPY:HP0745-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiY745_HELPY
    AccessioniPrimary (citable) accession number: O25441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3