Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O25441

- Y745_HELPY

UniProt

O25441 - Y745_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Uncharacterized RNA pseudouridine synthase HP_0745

Gene

HP_0745

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei136 – 1361By similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0745-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_0745 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_0745
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Uncharacterized RNA pseudouridine synthase HP_0745PRO_0000162735Add
BLAST

Proteomic databases

PRIDEiO25441.

Interactioni

Protein-protein interaction databases

DIPiDIP-3289N.
IntActiO25441. 2 interactions.
MINTiMINT-165354.
STRINGi85962.HP0745.

Structurei

3D structure databases

ProteinModelPortaliO25441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7968S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
KOiK06180.
OMAiLKMIALK.
OrthoDBiEOG6P070X.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKVFIALTD HKRLDEFLAK ELQISKNQVL NLIKEGLVFC QKKEVKKGGL
60 70 80 90 100
ALKEGDEITL LTPKITPKPL KKELDLEIEV IFEDEDLLVL NKPPNLVVHK
110 120 130 140 150
ALSVKEPTLV DWLEFKNYEL SNLGLKERYG IVHRLDKDTS GGIVIAKNNF
160 170 180 190 200
THVHLSEQLK TKMMGRYYIA LLSTPLKEEK MSVECYLTRN PNNRLKMIAL
210 220 230 240 250
KAVKKEKSRY SKSEFISLLT SQNNLNLIGA KLFTGRTHQI RAHLEYLNRH
260 270 280 290 300
IIGDNLYGLN GALPKEEIRI MLHAYLIEFK HPRSEQKLRF KVPLLKDMLE
310 320
YLKKVFDKEN LDEVLDEEKI LHAFIAK
Length:327
Mass (Da):37,922
Last modified:January 1, 1998 - v1
Checksum:i40E7F371C9E46117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07795.1.
PIRiA64613.
RefSeqiNP_207538.1. NC_000915.1.
YP_006934661.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07795; AAD07795; HP_0745.
GeneIDi13869930.
898915.
KEGGiheo:C694_03835.
hpy:HP0745.
PATRICi20592779. VBIHelPyl33062_0778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07795.1 .
PIRi A64613.
RefSeqi NP_207538.1. NC_000915.1.
YP_006934661.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3289N.
IntActi O25441. 2 interactions.
MINTi MINT-165354.
STRINGi 85962.HP0745.

Proteomic databases

PRIDEi O25441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07795 ; AAD07795 ; HP_0745 .
GeneIDi 13869930.
898915.
KEGGi heo:C694_03835.
hpy:HP0745.
PATRICi 20592779. VBIHelPyl33062_0778.

Phylogenomic databases

eggNOGi COG0564.
KOi K06180.
OMAi LKMIALK.
OrthoDBi EOG6P070X.

Enzyme and pathway databases

BioCyci HPY:HP0745-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
PROSITEi PS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiY745_HELPY
AccessioniPrimary (citable) accession number: O25441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3