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Protein

Uncharacterized RNA pseudouridine synthase HP_0745

Gene

HP_0745

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei136By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0745-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_0745 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_0745
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001627351 – 327Uncharacterized RNA pseudouridine synthase HP_0745Add BLAST327

Proteomic databases

PaxDbiO25441.

Interactioni

Protein-protein interaction databases

DIPiDIP-3289N.
IntActiO25441. 2 interactors.
MINTiMINT-165354.
STRINGi85962.HP0745.

Structurei

3D structure databases

ProteinModelPortaliO25441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 79S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C34. Bacteria.
COG0564. LUCA.
KOiK06180.
OMAiTSQNGMD.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKVFIALTD HKRLDEFLAK ELQISKNQVL NLIKEGLVFC QKKEVKKGGL
60 70 80 90 100
ALKEGDEITL LTPKITPKPL KKELDLEIEV IFEDEDLLVL NKPPNLVVHK
110 120 130 140 150
ALSVKEPTLV DWLEFKNYEL SNLGLKERYG IVHRLDKDTS GGIVIAKNNF
160 170 180 190 200
THVHLSEQLK TKMMGRYYIA LLSTPLKEEK MSVECYLTRN PNNRLKMIAL
210 220 230 240 250
KAVKKEKSRY SKSEFISLLT SQNNLNLIGA KLFTGRTHQI RAHLEYLNRH
260 270 280 290 300
IIGDNLYGLN GALPKEEIRI MLHAYLIEFK HPRSEQKLRF KVPLLKDMLE
310 320
YLKKVFDKEN LDEVLDEEKI LHAFIAK
Length:327
Mass (Da):37,922
Last modified:January 1, 1998 - v1
Checksum:i40E7F371C9E46117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07795.1.
PIRiA64613.
RefSeqiNP_207538.1. NC_000915.1.
WP_001174316.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07795; AAD07795; HP_0745.
GeneIDi898915.
KEGGiheo:C694_03835.
hpy:HP0745.
PATRICi20592779. VBIHelPyl33062_0778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07795.1.
PIRiA64613.
RefSeqiNP_207538.1. NC_000915.1.
WP_001174316.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3289N.
IntActiO25441. 2 interactors.
MINTiMINT-165354.
STRINGi85962.HP0745.

Proteomic databases

PaxDbiO25441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07795; AAD07795; HP_0745.
GeneIDi898915.
KEGGiheo:C694_03835.
hpy:HP0745.
PATRICi20592779. VBIHelPyl33062_0778.

Phylogenomic databases

eggNOGiENOG4105C34. Bacteria.
COG0564. LUCA.
KOiK06180.
OMAiTSQNGMD.

Enzyme and pathway databases

BioCyciHPY:HP0745-MONOMER.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY745_HELPY
AccessioniPrimary (citable) accession number: O25441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.