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O25441 (Y745_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized RNA pseudouridine synthase HP_0745

EC=5.4.99.-
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene names
Ordered Locus Names:HP_0745
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

RNA uridine = RNA pseudouridine.

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Uncharacterized RNA pseudouridine synthase HP_0745
PRO_0000162735

Regions

Domain12 – 7968S4 RNA-binding

Sites

Active site1361 By similarity

Sequences

Sequence LengthMass (Da)Tools
O25441 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 40E7F371C9E46117

FASTA32737,922
        10         20         30         40         50         60 
MQKVFIALTD HKRLDEFLAK ELQISKNQVL NLIKEGLVFC QKKEVKKGGL ALKEGDEITL 

        70         80         90        100        110        120 
LTPKITPKPL KKELDLEIEV IFEDEDLLVL NKPPNLVVHK ALSVKEPTLV DWLEFKNYEL 

       130        140        150        160        170        180 
SNLGLKERYG IVHRLDKDTS GGIVIAKNNF THVHLSEQLK TKMMGRYYIA LLSTPLKEEK 

       190        200        210        220        230        240 
MSVECYLTRN PNNRLKMIAL KAVKKEKSRY SKSEFISLLT SQNNLNLIGA KLFTGRTHQI 

       250        260        270        280        290        300 
RAHLEYLNRH IIGDNLYGLN GALPKEEIRI MLHAYLIEFK HPRSEQKLRF KVPLLKDMLE 

       310        320 
YLKKVFDKEN LDEVLDEEKI LHAFIAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07795.1.
PIRA64613.
RefSeqNP_207538.1. NC_000915.1.
YP_006934661.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3289N.
IntActO25441. 1 interaction.
MINTMINT-165354.
STRING85962.HP0745.

Proteomic databases

PRIDEO25441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07795; AAD07795; HP_0745.
GeneID13869930.
898915.
KEGGheo:C694_03835.
hpy:HP0745.
PATRIC20592779. VBIHelPyl33062_0778.

Phylogenomic databases

eggNOGCOG0564.
KOK06180.
OMALKMIALK.
OrthoDBEOG6P070X.
ProtClustDBCLSK872435.

Enzyme and pathway databases

BioCycHPY:HP0745-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00005. rluA_subfam. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY745_HELPY
AccessionPrimary (citable) accession number: O25441
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names