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O25434 (RIMO_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal protein S12 methylthiotransferase RimO

Short name=S12 MTTase
Short name=S12 methylthiotransferase
EC=2.-.-.-
Alternative name(s):
Ribosome maturation factor RimO
Gene names
Name:rimO
Ordered Locus Names:HP_0734
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 By similarity. HAMAP-Rule MF_01865

Cofactor

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01865.

Sequence similarities

Belongs to the methylthiotransferase family. RimO subfamily.

Contains 1 MTTase N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Ribosomal protein S12 methylthiotransferase RimO HAMAP-Rule MF_01865
PRO_0000374856

Regions

Domain7 – 119113MTTase N-terminal

Sites

Metal binding161Iron-sulfur (4Fe-4S) By similarity
Metal binding501Iron-sulfur (4Fe-4S) By similarity
Metal binding821Iron-sulfur (4Fe-4S) By similarity
Metal binding1511Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1551Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1581Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
O25434 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 59DDFC8721CC42EB

FASTA43949,634
        10         20         30         40         50         60 
MQVKENKQLC LISLGCSKNL VDSEVMLGKL YNYTLTNDAK SADVILINTC GFIESAKQES 

        70         80         90        100        110        120 
IQTILNAAKD KKEGAILIAS GCLSERYKDE IKELIPEVDI FTGVGDYDKI DIMIAKKQNQ 

       130        140        150        160        170        180 
FSEQVFLSEH YNARIITGSS VHAYVKISEG CNQKCSFCAI PSFKGKLQSR ELDSILKEVE 

       190        200        210        220        230        240 
NLALKGYTDM TFIAQDSSSF LYDKGQKDGL IQLIRAIDKQ QALKSARILY LYPSSTTLEL 

       250        260        270        280        290        300 
IGAIESSPIF QNYFDMPIQH ISDSMLKKMR RNSSQAHHLK LLDAMKQVKE SFIRSTIIVG 

       310        320        330        340        350        360 
HPEENESEFE ELSAFLDEFQ FDRLNIFAFS AEENTHAYSL EKVPKKTINA RIKALNKIAL 

       370        380        390        400        410        420 
KHQNHSFKAL LNKPIKALVE NKEGEYFYKA RDLRWAPEVD GEILINDSEL TTPLKPGHYT 

       430 
IAPSEFKDNI LLAKVLSPF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07780.1.
PIRF64611.
RefSeqNP_207528.1. NC_000915.1.
YP_006934650.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25434.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0734.

Proteomic databases

PRIDEO25434.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07780; AAD07780; HP_0734.
GeneID899326.
KEGGheo:C694_03770.
hpy:HP0734.
PATRIC20592755. VBIHelPyl33062_0766.

Phylogenomic databases

eggNOGCOG0621.
OMAPHDPFID.
OrthoDBEOG6P5ZD8.

Enzyme and pathway databases

BioCycHPY:HP0734-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPMF_01865. MTTase_RimO.
InterProIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PANTHERPTHR11918. PTHR11918. 1 hit.
PfamPF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIMO_HELPY
AccessionPrimary (citable) accession number: O25434
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names