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O25434

- RIMO_HELPY

UniProt

O25434 - RIMO_HELPY

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Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene
rimO, HP_0734
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 By similarity.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161Iron-sulfur (4Fe-4S) By similarity
Metal bindingi50 – 501Iron-sulfur (4Fe-4S) By similarity
Metal bindingi82 – 821Iron-sulfur (4Fe-4S) By similarity
Metal bindingi151 – 1511Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi155 – 1551Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi158 – 1581Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP
  3. transferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
  2. RNA modification Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP0734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S12 methylthiotransferase RimO (EC:2.-.-.-)
Short name:
S12 MTTase
Short name:
S12 methylthiotransferase
Alternative name(s):
Ribosome maturation factor RimO
Gene namesi
Name:rimO
Ordered Locus Names:HP_0734
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Ribosomal protein S12 methylthiotransferase RimOUniRule annotationPRO_0000374856Add
BLAST

Proteomic databases

PRIDEiO25434.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0734.

Structurei

3D structure databases

ProteinModelPortaliO25434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 119113MTTase N-terminalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0621.
OMAiPHDPFID.
OrthoDBiEOG6P5ZD8.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPiMF_01865. MTTase_RimO.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25434-1 [UniParc]FASTAAdd to Basket

« Hide

MQVKENKQLC LISLGCSKNL VDSEVMLGKL YNYTLTNDAK SADVILINTC    50
GFIESAKQES IQTILNAAKD KKEGAILIAS GCLSERYKDE IKELIPEVDI 100
FTGVGDYDKI DIMIAKKQNQ FSEQVFLSEH YNARIITGSS VHAYVKISEG 150
CNQKCSFCAI PSFKGKLQSR ELDSILKEVE NLALKGYTDM TFIAQDSSSF 200
LYDKGQKDGL IQLIRAIDKQ QALKSARILY LYPSSTTLEL IGAIESSPIF 250
QNYFDMPIQH ISDSMLKKMR RNSSQAHHLK LLDAMKQVKE SFIRSTIIVG 300
HPEENESEFE ELSAFLDEFQ FDRLNIFAFS AEENTHAYSL EKVPKKTINA 350
RIKALNKIAL KHQNHSFKAL LNKPIKALVE NKEGEYFYKA RDLRWAPEVD 400
GEILINDSEL TTPLKPGHYT IAPSEFKDNI LLAKVLSPF 439
Length:439
Mass (Da):49,634
Last modified:January 1, 1998 - v1
Checksum:i59DDFC8721CC42EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07780.1.
PIRiF64611.
RefSeqiNP_207528.1. NC_000915.1.
YP_006934650.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07780; AAD07780; HP_0734.
GeneIDi13869918.
899326.
KEGGiheo:C694_03770.
hpy:HP0734.
PATRICi20592755. VBIHelPyl33062_0766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07780.1 .
PIRi F64611.
RefSeqi NP_207528.1. NC_000915.1.
YP_006934650.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0734.

Proteomic databases

PRIDEi O25434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07780 ; AAD07780 ; HP_0734 .
GeneIDi 13869918.
899326.
KEGGi heo:C694_03770.
hpy:HP0734.
PATRICi 20592755. VBIHelPyl33062_0766.

Phylogenomic databases

eggNOGi COG0621.
OMAi PHDPFID.
OrthoDBi EOG6P5ZD8.

Enzyme and pathway databases

BioCyci HPY:HP0734-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPi MF_01865. MTTase_RimO.
InterProi IPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
PANTHERi PTHR11918. PTHR11918. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEi PS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRIMO_HELPY
AccessioniPrimary (citable) accession number: O25434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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