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O25427

- DUS_HELPY

UniProt

O25427 - DUS_HELPY

Protein

Probable tRNA-dihydrouridine synthase

Gene

dus

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

    Cofactori

    FAD.By similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. tRNA dihydrouridine synthase activity Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciHPY:HP0727-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tRNA-dihydrouridine synthase (EC:1.-.-.-)
    Gene namesi
    Name:dus
    Ordered Locus Names:HP_0727
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Probable tRNA-dihydrouridine synthasePRO_0000162134Add
    BLAST

    Proteomic databases

    PRIDEiO25427.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3615N.
    IntActiO25427. 1 interaction.
    MINTiMINT-185296.
    STRINGi85962.HP0727.

    Structurei

    3D structure databases

    ProteinModelPortaliO25427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Dus family.Curated

    Phylogenomic databases

    eggNOGiCOG0042.
    KOiK05540.
    OMAiRYQKDKI.
    OrthoDBiEOG6VHZFQ.

    Family and domain databases

    Gene3Di1.10.1200.80. 1 hit.
    3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR024036. tRNA-dHydroUridine_Synthase_C.
    IPR001269. tRNA_hU_synthase.
    IPR018517. tRNA_hU_synthase_CS.
    [Graphical view]
    PANTHERiPTHR11082. PTHR11082. 1 hit.
    PfamiPF01207. Dus. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006621. Dus. 1 hit.
    PROSITEiPS01136. UPF0034. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25427-1 [UniParc]FASTAAdd to Basket

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    MDFKNKKWLF LAPLAGYTDL PFRSVVKKFG VDVTTSEMVS SHSLVYAFDK    50
    TSKMLEKSPL EDHFMAQISG SKESVVKEAV EKINALEHVN GIDFNCGCPA 100
    PKVANHGNGS GLLKDLNHLV KLLKTIRENT SKKITSVKVR LGFEKKIPKE 150
    IAHALNDAPV DYVVVHGRTR SDKYQKDKID YESIALMKKI LKKPVIANGE 200
    IDSVKKAFEV LQITQADGLM IGRAALRAPW IFWQIRNNTT KLPAVVKKDL 250
    VLEHFDKMVE FYGDMGVIMF RKNLHAYAKG EMQASAFRNC VNTLTEIKSM 300
    RESIEEFFNQ EMLQSEVPLW VELNQKSV 328
    Length:328
    Mass (Da):37,150
    Last modified:January 1, 1998 - v1
    Checksum:iD4F3494C7CF0B6B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07774.1.
    PIRiG64610.
    RefSeqiNP_207521.1. NC_000915.1.
    YP_006934644.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07774; AAD07774; HP_0727.
    GeneIDi13869912.
    898757.
    KEGGiheo:C694_03740.
    hpy:HP0727.
    PATRICi20592741. VBIHelPyl33062_0759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07774.1 .
    PIRi G64610.
    RefSeqi NP_207521.1. NC_000915.1.
    YP_006934644.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3615N.
    IntActi O25427. 1 interaction.
    MINTi MINT-185296.
    STRINGi 85962.HP0727.

    Proteomic databases

    PRIDEi O25427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07774 ; AAD07774 ; HP_0727 .
    GeneIDi 13869912.
    898757.
    KEGGi heo:C694_03740.
    hpy:HP0727.
    PATRICi 20592741. VBIHelPyl33062_0759.

    Phylogenomic databases

    eggNOGi COG0042.
    KOi K05540.
    OMAi RYQKDKI.
    OrthoDBi EOG6VHZFQ.

    Enzyme and pathway databases

    BioCyci HPY:HP0727-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1200.80. 1 hit.
    3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR024036. tRNA-dHydroUridine_Synthase_C.
    IPR001269. tRNA_hU_synthase.
    IPR018517. tRNA_hU_synthase_CS.
    [Graphical view ]
    PANTHERi PTHR11082. PTHR11082. 1 hit.
    Pfami PF01207. Dus. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006621. Dus. 1 hit.
    PROSITEi PS01136. UPF0034. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDUS_HELPY
    AccessioniPrimary (citable) accession number: O25427
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3