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Protein

Probable tRNA-dihydrouridine synthase

Gene

dus

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciHPY:HP0727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-dihydrouridine synthase (EC:1.-.-.-)
Gene namesi
Name:dus
Ordered Locus Names:HP_0727
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Probable tRNA-dihydrouridine synthasePRO_0000162134Add
BLAST

Proteomic databases

PRIDEiO25427.

Interactioni

Protein-protein interaction databases

DIPiDIP-3615N.
IntActiO25427. 1 interaction.
MINTiMINT-185296.
STRINGi85962.HP0727.

Structurei

3D structure databases

ProteinModelPortaliO25427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family.Curated

Phylogenomic databases

eggNOGiCOG0042.
KOiK05540.
OMAiGAIMFRK.
OrthoDBiEOG6VHZFQ.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKNKKWLF LAPLAGYTDL PFRSVVKKFG VDVTTSEMVS SHSLVYAFDK
60 70 80 90 100
TSKMLEKSPL EDHFMAQISG SKESVVKEAV EKINALEHVN GIDFNCGCPA
110 120 130 140 150
PKVANHGNGS GLLKDLNHLV KLLKTIRENT SKKITSVKVR LGFEKKIPKE
160 170 180 190 200
IAHALNDAPV DYVVVHGRTR SDKYQKDKID YESIALMKKI LKKPVIANGE
210 220 230 240 250
IDSVKKAFEV LQITQADGLM IGRAALRAPW IFWQIRNNTT KLPAVVKKDL
260 270 280 290 300
VLEHFDKMVE FYGDMGVIMF RKNLHAYAKG EMQASAFRNC VNTLTEIKSM
310 320
RESIEEFFNQ EMLQSEVPLW VELNQKSV
Length:328
Mass (Da):37,150
Last modified:January 1, 1998 - v1
Checksum:iD4F3494C7CF0B6B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07774.1.
PIRiG64610.
RefSeqiNP_207521.1. NC_000915.1.
WP_000346174.1. NC_018939.1.
YP_006934644.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07774; AAD07774; HP_0727.
GeneIDi898757.
KEGGiheo:C694_03740.
hpy:HP0727.
PATRICi20592741. VBIHelPyl33062_0759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07774.1.
PIRiG64610.
RefSeqiNP_207521.1. NC_000915.1.
WP_000346174.1. NC_018939.1.
YP_006934644.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3615N.
IntActiO25427. 1 interaction.
MINTiMINT-185296.
STRINGi85962.HP0727.

Proteomic databases

PRIDEiO25427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07774; AAD07774; HP_0727.
GeneIDi898757.
KEGGiheo:C694_03740.
hpy:HP0727.
PATRICi20592741. VBIHelPyl33062_0759.

Phylogenomic databases

eggNOGiCOG0042.
KOiK05540.
OMAiGAIMFRK.
OrthoDBiEOG6VHZFQ.

Enzyme and pathway databases

BioCyciHPY:HP0727-MONOMER.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDUS_HELPY
AccessioniPrimary (citable) accession number: O25427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.