Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O25427 (DUS_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable tRNA-dihydrouridine synthase

EC=1.-.-.-
Gene names
Name:dus
Ordered Locus Names:HP_0727
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs By similarity.

Cofactor

FAD By similarity.

Sequence similarities

Belongs to the Dus family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

tRNA dihydrouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Probable tRNA-dihydrouridine synthase
PRO_0000162134

Sequences

Sequence LengthMass (Da)Tools
O25427 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D4F3494C7CF0B6B3

FASTA32837,150
        10         20         30         40         50         60 
MDFKNKKWLF LAPLAGYTDL PFRSVVKKFG VDVTTSEMVS SHSLVYAFDK TSKMLEKSPL 

        70         80         90        100        110        120 
EDHFMAQISG SKESVVKEAV EKINALEHVN GIDFNCGCPA PKVANHGNGS GLLKDLNHLV 

       130        140        150        160        170        180 
KLLKTIRENT SKKITSVKVR LGFEKKIPKE IAHALNDAPV DYVVVHGRTR SDKYQKDKID 

       190        200        210        220        230        240 
YESIALMKKI LKKPVIANGE IDSVKKAFEV LQITQADGLM IGRAALRAPW IFWQIRNNTT 

       250        260        270        280        290        300 
KLPAVVKKDL VLEHFDKMVE FYGDMGVIMF RKNLHAYAKG EMQASAFRNC VNTLTEIKSM 

       310        320 
RESIEEFFNQ EMLQSEVPLW VELNQKSV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07774.1.
PIRG64610.
RefSeqNP_207521.1. NC_000915.1.
YP_006934644.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3615N.
IntActO25427. 1 interaction.
MINTMINT-185296.
STRING85962.HP0727.

Proteomic databases

PRIDEO25427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07774; AAD07774; HP_0727.
GeneID898757.
KEGGheo:C694_03740.
hpy:HP0727.
PATRIC20592741. VBIHelPyl33062_0759.

Phylogenomic databases

eggNOGCOG0042.
KOK05540.
OMARYQKDKI.
OrthoDBEOG6VHZFQ.

Enzyme and pathway databases

BioCycHPY:HP0727-MONOMER.

Family and domain databases

Gene3D1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERPTHR11082. PTHR11082. 1 hit.
PfamPF01207. Dus. 1 hit.
[Graphical view]
PIRSFPIRSF006621. Dus. 1 hit.
PROSITEPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUS_HELPY
AccessionPrimary (citable) accession number: O25427
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names