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O25427

- DUS_HELPY

UniProt

O25427 - DUS_HELPY

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Protein
Probable tRNA-dihydrouridine synthase
Gene
dus, HP_0727
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs By similarity.

Cofactori

FAD By similarity.

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. tRNA dihydrouridine synthase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciHPY:HP0727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-dihydrouridine synthase (EC:1.-.-.-)
Gene namesi
Name:dus
Ordered Locus Names:HP_0727
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Probable tRNA-dihydrouridine synthase
PRO_0000162134Add
BLAST

Proteomic databases

PRIDEiO25427.

Interactioni

Protein-protein interaction databases

DIPiDIP-3615N.
IntActiO25427. 1 interaction.
MINTiMINT-185296.
STRINGi85962.HP0727.

Structurei

3D structure databases

ProteinModelPortaliO25427.

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family.

Phylogenomic databases

eggNOGiCOG0042.
KOiK05540.
OMAiRYQKDKI.
OrthoDBiEOG6VHZFQ.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25427-1 [UniParc]FASTAAdd to Basket

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MDFKNKKWLF LAPLAGYTDL PFRSVVKKFG VDVTTSEMVS SHSLVYAFDK    50
TSKMLEKSPL EDHFMAQISG SKESVVKEAV EKINALEHVN GIDFNCGCPA 100
PKVANHGNGS GLLKDLNHLV KLLKTIRENT SKKITSVKVR LGFEKKIPKE 150
IAHALNDAPV DYVVVHGRTR SDKYQKDKID YESIALMKKI LKKPVIANGE 200
IDSVKKAFEV LQITQADGLM IGRAALRAPW IFWQIRNNTT KLPAVVKKDL 250
VLEHFDKMVE FYGDMGVIMF RKNLHAYAKG EMQASAFRNC VNTLTEIKSM 300
RESIEEFFNQ EMLQSEVPLW VELNQKSV 328
Length:328
Mass (Da):37,150
Last modified:January 1, 1998 - v1
Checksum:iD4F3494C7CF0B6B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07774.1.
PIRiG64610.
RefSeqiNP_207521.1. NC_000915.1.
YP_006934644.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07774; AAD07774; HP_0727.
GeneIDi13869912.
898757.
KEGGiheo:C694_03740.
hpy:HP0727.
PATRICi20592741. VBIHelPyl33062_0759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07774.1 .
PIRi G64610.
RefSeqi NP_207521.1. NC_000915.1.
YP_006934644.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3615N.
IntActi O25427. 1 interaction.
MINTi MINT-185296.
STRINGi 85962.HP0727.

Proteomic databases

PRIDEi O25427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07774 ; AAD07774 ; HP_0727 .
GeneIDi 13869912.
898757.
KEGGi heo:C694_03740.
hpy:HP0727.
PATRICi 20592741. VBIHelPyl33062_0759.

Phylogenomic databases

eggNOGi COG0042.
KOi K05540.
OMAi RYQKDKI.
OrthoDBi EOG6VHZFQ.

Enzyme and pathway databases

BioCyci HPY:HP0727-MONOMER.

Family and domain databases

Gene3Di 1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view ]
PANTHERi PTHR11082. PTHR11082. 1 hit.
Pfami PF01207. Dus. 1 hit.
[Graphical view ]
PIRSFi PIRSF006621. Dus. 1 hit.
PROSITEi PS01136. UPF0034. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDUS_HELPY
AccessioniPrimary (citable) accession number: O25427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi