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Protein

Probable L-asparaginase

Gene

ansA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-asparagine + H2O = L-aspartate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16O-isoaspartyl threonine intermediatePROSITE-ProRule annotation1
Binding sitei62SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-asparaginase (EC:3.5.1.1)
Short name:
L-ASNase
Alternative name(s):
L-asparagine amidohydrolase
Gene namesi
Name:ansA
Synonyms:asn
Ordered Locus Names:HP_0723
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001710811 – 330Probable L-asparaginaseAdd BLAST330

Proteomic databases

PaxDbiO25424
PRIDEiO25424

Interactioni

Protein-protein interaction databases

DIPiDIP-3115N
IntActiO25424, 1 interactor
MINTiO25424
STRINGi85962.HP0723

Structurei

3D structure databases

ProteinModelPortaliO25424
SMRiO25424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 330Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST325

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 96Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the asparaginase 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105HDK Bacteria
COG0252 LUCA
KOiK01424
OMAiNVYSTGR

Family and domain databases

Gene3Di3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR004550 AsnASE_II
IPR036152 Asp/glu_Ase-like_sf
IPR006034 Asparaginase/glutaminase-like
IPR020827 Asparaginase/glutaminase_AS1
IPR027475 Asparaginase/glutaminase_AS2
IPR027473 L-asparaginase_C
IPR027474 L-asparaginase_N
IPR037152 L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710 Asparaginase, 1 hit
PIRSFiPIRSF001220 L-ASNase_gatD, 1 hit
PRINTSiPR00139 ASNGLNASE
SMARTiView protein in SMART
SM00870 Asparaginase, 1 hit
SUPFAMiSSF53774 SSF53774, 1 hit
TIGRFAMsiTIGR00520 asnASE_II, 1 hit
PROSITEiView protein in PROSITE
PS00144 ASN_GLN_ASE_1, 1 hit
PS00917 ASN_GLN_ASE_2, 1 hit
PS51732 ASN_GLN_ASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

O25424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNLPTIAL LATGGTIAGS GASASLGSYK SGELGIKELL KAIPSLNRLA
60 70 80 90 100
RIQGEQISNI GSQDMNEEVW FKLAKRAQEL LDDSRIQGVV ITHGTDTLEE
110 120 130 140 150
SAYFLNLVLR STKPVVLVGA MRNAASLSAD GALNLYNAVS VALNEKSANK
160 170 180 190 200
GVLVVMDDNI FSAREVIKTH TTHTSTFKAL NSGAIGSVYY GKTRYYMQPL
210 220 230 240 250
RKHTTESEFS LSQLKTPLPK VDIIYTHAGM TPDLFQASLN SHAKGVVIAG
260 270 280 290 300
VGNGNVSAGF LKAMQEASQM GVVIVRSSRV NSGEITSGEI DDKAFITSDN
310 320 330
LNPQKARVLL QLALTKTNNK EKIQEMFEEY
Length:330
Mass (Da):35,539
Last modified:January 1, 1998 - v1
Checksum:i9A2BB6DC7ED9D7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07772.1
PIRiC64610
RefSeqiNP_207517.1, NC_000915.1
WP_000068360.1, NC_000915.1

Genome annotation databases

EnsemblBacteriaiAAD07772; AAD07772; HP_0723
GeneIDi898763
KEGGiheo:C694_03720
hpy:HP0723
PATRICifig|85962.47.peg.772

Similar proteinsi

Entry informationi

Entry nameiASPG_HELPY
AccessioniPrimary (citable) accession number: O25424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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