ID   FEOB_HELPY              Reviewed;         642 AA.
AC   O25396;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB; OrderedLocusNames=HP_0687;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487;
RX   PubMed=10931324; DOI=10.1046/j.1365-2958.2000.01987.x;
RA   Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L.,
RA   Andrews S.C., Kelly D.J.;
RT   "Iron acquisition and virulence in Helicobacter pylori: a major role for
RT   FeoB, a high-affinity ferrous iron transporter.";
RL   Mol. Microbiol. 37:274-286(2000).
CC   -!- FUNCTION: Probable transporter of an ATP-driven Fe(2+) uptake system.
CC       {ECO:0000269|PubMed:10931324}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- DISRUPTION PHENOTYPE: Cells are unable to colonize the gastric mucosa
CC       of mice. {ECO:0000269|PubMed:10931324}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01048}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000511; AAD07741.1; -; Genomic_DNA.
DR   PIR; G64605; G64605.
DR   RefSeq; NP_207481.1; NC_000915.1.
DR   RefSeq; WP_000659176.1; NC_018939.1.
DR   AlphaFoldDB; O25396; -.
DR   SMR; O25396; -.
DR   DIP; DIP-3079N; -.
DR   IntAct; O25396; 19.
DR   MINT; O25396; -.
DR   STRING; 85962.HP_0687; -.
DR   TCDB; 9.A.8.1.2; the ferrous iron uptake (feob) family.
DR   PaxDb; 85962-C694_03545; -.
DR   EnsemblBacteria; AAD07741; AAD07741; HP_0687.
DR   KEGG; hpy:HP_0687; -.
DR   PATRIC; fig|85962.47.peg.736; -.
DR   eggNOG; COG0370; Bacteria.
DR   InParanoid; O25396; -.
DR   OrthoDB; 9809127at2; -.
DR   PhylomeDB; O25396; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00437; feoB; 1.
DR   PANTHER; PTHR43185:SF1; FE(2+) TRANSPORTER FEOB; 1.
DR   PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; GTP-binding;
KW   Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..642
FT                   /note="Fe(2+) transporter FeoB"
FT                   /id="PRO_0000210830"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        586..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          3..168
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         35..39
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         56..59
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         116..119
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         145..147
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ   SEQUENCE   642 AA;  71423 MW;  D6784C7153E8A3BC CRC64;
     MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH QITIIDLPGT
     YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL SAQLLDTNKK MLLALNMWDE
     AQKEGIKINT EKLSKELGVV CVPTSARSKE DRLNTELLLD EIVRLYSQNT TNNENIKVPS
     QSFKESLKYS QSAQRIAQLV ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL
     SFLIGGGVQK ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG
     ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT LQNYNERLIT
     LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG AVVALVMAKL LKLSVFKGQT
     ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL KKAGTYILVG AILIWFMSQY PKSDAAMKAY
     KQESLLVNKD TTLSSEAKEE KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS
     VSLVTGFMAK EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF
     AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV
//