Ferrous iron transport protein B - Helicobacter pylori (strain ATCC 700392 / 26695)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Ferrous iron transport protein B

Gene names

Name:	feoB
Ordered Locus Names:	HP_0687

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-driven Fe²⁺ uptake system. Ref.2
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Disruption phenotype	Cells are unable to colonize the gastric mucosa of mice. Ref.2
Sequence similarities	Belongs to the FeoB (TC 9.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Iron Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP binding Inferred from electronic annotation. Source: InterPro ferrous iron transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 642

642

Ferrous iron transport protein B

PRO_0000210830

Regions

Transmembrane

226 – 246

21

Helical; Potential

Transmembrane

279 – 299

21

Helical; Potential

Transmembrane

361 – 381

21

Helical; Potential

Transmembrane

388 – 408

21

Helical; Potential

Transmembrane

447 – 467

21

Helical; Potential

Transmembrane

541 – 561

21

Helical; Potential

Transmembrane

586 – 606

21

Helical; Potential

Transmembrane

615 – 635

21

Helical; Potential

Nucleotide binding

10 – 17

8

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O25396 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D6784C7153E8A3BC
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FASTA

642

71,423

        10         20         30         40         50         60 
MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH QITIIDLPGT 

        70         80         90        100        110        120 
YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL SAQLLDTNKK MLLALNMWDE 

       130        140        150        160        170        180 
AQKEGIKINT EKLSKELGVV CVPTSARSKE DRLNTELLLD EIVRLYSQNT TNNENIKVPS 

       190        200        210        220        230        240 
QSFKESLKYS QSAQRIAQLV ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL 

       250        260        270        280        290        300 
SFLIGGGVQK ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG 

       310        320        330        340        350        360 
ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT LQNYNERLIT 

       370        380        390        400        410        420 
LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG AVVALVMAKL LKLSVFKGQT 

       430        440        450        460        470        480 
ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL KKAGTYILVG AILIWFMSQY PKSDAAMKAY 

       490        500        510        520        530        540 
KQESLLVNKD TTLSSEAKEE KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS 

       550        560        570        580        590        600 
VSLVTGFMAK EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF 

       610        620        630        640 
AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter." Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L., Andrews S.C., Kelly D.J. Mol. Microbiol. 37:274-286(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE. Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07741.1.
PIR	G64605.
RefSeq	NP_207481.1. NC_000915.1. YP_006934609.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25396.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3079N.
MINT	MINT-161005.
STRING	85962.HP0687.
Protein family/group databases
TCDB	9.A.8.1.2. ferrous iron uptake (FeoB) family.
PTM databases
PhosSite	P11071046.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07741; AAD07741; HP_0687.
GeneID	13869877. 898903.
KEGG	heo:C694_03545. hpy:HP0687.
PATRIC	20592659. VBIHelPyl33062_0718.
Phylogenomic databases
eggNOG	COG0370.
KO	K04759.
OMA	HAWRRTA.
ProtClustDB	CLSK496156.
Family and domain databases
InterPro	IPR003373. Fe2_transport_prot-B. IPR011640. Fe2_transport_prot_B_C. IPR011619. Fe2_transport_prot_B_N. IPR011642. Nucleoside_recog_Gate. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF07664. FeoB_C. 1 hit. PF02421. FeoB_N. 1 hit. PF07670. Gate. 2 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00437. feoB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FEOB_HELPY

Accession

Primary (citable) accession number: O25396

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	January 1, 1998
Last modified:	May 29, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents