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O25396 (FEOB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrous iron transport protein B
Gene names
Name:feoB
Ordered Locus Names:HP_0687
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-driven Fe2+ uptake system. Ref.2

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Disruption phenotype

Cells are unable to colonize the gastric mucosa of mice. Ref.2

Sequence similarities

Belongs to the FeoB (TC 9.A.8) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Ferrous iron transport protein B
PRO_0000210830

Regions

Transmembrane226 – 24621Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane388 – 40821Helical; Potential
Transmembrane447 – 46721Helical; Potential
Transmembrane541 – 56121Helical; Potential
Transmembrane586 – 60621Helical; Potential
Transmembrane615 – 63521Helical; Potential
Nucleotide binding10 – 178ATP Potential

Sequences

Sequence LengthMass (Da)Tools
O25396 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D6784C7153E8A3BC

FASTA64271,423
        10         20         30         40         50         60 
MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH QITIIDLPGT 

        70         80         90        100        110        120 
YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL SAQLLDTNKK MLLALNMWDE 

       130        140        150        160        170        180 
AQKEGIKINT EKLSKELGVV CVPTSARSKE DRLNTELLLD EIVRLYSQNT TNNENIKVPS 

       190        200        210        220        230        240 
QSFKESLKYS QSAQRIAQLV ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL 

       250        260        270        280        290        300 
SFLIGGGVQK ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG 

       310        320        330        340        350        360 
ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT LQNYNERLIT 

       370        380        390        400        410        420 
LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG AVVALVMAKL LKLSVFKGQT 

       430        440        450        460        470        480 
ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL KKAGTYILVG AILIWFMSQY PKSDAAMKAY 

       490        500        510        520        530        540 
KQESLLVNKD TTLSSEAKEE KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS 

       550        560        570        580        590        600 
VSLVTGFMAK EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF 

       610        620        630        640 
AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07741.1.
PIRG64605.
RefSeqNP_207481.1. NC_000915.1.
YP_006934609.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25396.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3079N.
IntActO25396. 19 interactions.
MINTMINT-161005.
STRING85962.HP0687.

Protein family/group databases

TCDB9.A.8.1.2. the ferrous iron uptake (feob) family.

PTM databases

PhosSiteP11071046.

Proteomic databases

PRIDEO25396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07741; AAD07741; HP_0687.
GeneID13869877.
898903.
KEGGheo:C694_03545.
hpy:HP0687.
PATRIC20592659. VBIHelPyl33062_0718.

Phylogenomic databases

eggNOGCOG0370.
KOK04759.
OMAFMAKEVV.
OrthoDBEOG6JQH16.
ProtClustDBCLSK496156.

Enzyme and pathway databases

BioCycHPY:HP0687-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003373. Fe2_transport_prot-B.
IPR011640. Fe2_transport_prot_B_C.
IPR011619. Fe2_transport_prot_B_N.
IPR011642. Nucleoside_recog_Gate.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF07664. FeoB_C. 1 hit.
PF02421. FeoB_N. 1 hit.
PF07670. Gate. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00437. feoB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFEOB_HELPY
AccessionPrimary (citable) accession number: O25396
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names