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Protein

Ferrous iron transport protein B

Gene

feoB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-driven Fe2+ uptake system.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ferrous iron transmembrane transporter activity Source: InterPro
  3. GTP binding Source: InterPro

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

ATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0687-MONOMER.

Protein family/group databases

TCDBi9.A.8.1.2. the ferrous iron uptake (feob) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrous iron transport protein B
Gene namesi
Name:feoB
Ordered Locus Names:HP_0687
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST
Transmembranei541 – 56121HelicalSequence AnalysisAdd
BLAST
Transmembranei586 – 60621HelicalSequence AnalysisAdd
BLAST
Transmembranei615 – 63521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells are unable to colonize the gastric mucosa of mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Ferrous iron transport protein BPRO_0000210830Add
BLAST

Proteomic databases

PRIDEiO25396.

Interactioni

Protein-protein interaction databases

DIPiDIP-3079N.
IntActiO25396. 19 interactions.
MINTiMINT-161005.
STRINGi85962.HP0687.

Structurei

3D structure databases

ProteinModelPortaliO25396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 168166FeoB-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. [View classification]PROSITE-ProRule annotation
Contains 1 FeoB-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0370.
KOiK04759.
OMAiFMAKEVV.
OrthoDBiEOG6JQH16.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003373. Fe2_transport_prot-B.
IPR011640. Fe2_transport_prot_B_C.
IPR011619. Fe2_transport_prot_B_N.
IPR030389. G_FEOB_dom.
IPR011642. Nucleoside_recog_Gate.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11649:SF37. PTHR11649:SF37. 1 hit.
PfamiPF07664. FeoB_C. 1 hit.
PF02421. FeoB_N. 1 hit.
PF07670. Gate. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00437. feoB. 1 hit.
PROSITEiPS51711. G_FEOB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH
60 70 80 90 100
QITIIDLPGT YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL
110 120 130 140 150
SAQLLDTNKK MLLALNMWDE AQKEGIKINT EKLSKELGVV CVPTSARSKE
160 170 180 190 200
DRLNTELLLD EIVRLYSQNT TNNENIKVPS QSFKESLKYS QSAQRIAQLV
210 220 230 240 250
ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL SFLIGGGVQK
260 270 280 290 300
ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG
310 320 330 340 350
ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT
360 370 380 390 400
LQNYNERLIT LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG
410 420 430 440 450
AVVALVMAKL LKLSVFKGQT ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL
460 470 480 490 500
KKAGTYILVG AILIWFMSQY PKSDAAMKAY KQESLLVNKD TTLSSEAKEE
510 520 530 540 550
KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS VSLVTGFMAK
560 570 580 590 600
EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF
610 620 630 640
AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV
Length:642
Mass (Da):71,423
Last modified:January 1, 1998 - v1
Checksum:iD6784C7153E8A3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07741.1.
PIRiG64605.
RefSeqiNP_207481.1. NC_000915.1.
YP_006934609.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07741; AAD07741; HP_0687.
GeneIDi898903.
KEGGiheo:C694_03545.
hpy:HP0687.
PATRICi20592659. VBIHelPyl33062_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07741.1.
PIRiG64605.
RefSeqiNP_207481.1. NC_000915.1.
YP_006934609.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3079N.
IntActiO25396. 19 interactions.
MINTiMINT-161005.
STRINGi85962.HP0687.

Protein family/group databases

TCDBi9.A.8.1.2. the ferrous iron uptake (feob) family.

Proteomic databases

PRIDEiO25396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07741; AAD07741; HP_0687.
GeneIDi898903.
KEGGiheo:C694_03545.
hpy:HP0687.
PATRICi20592659. VBIHelPyl33062_0718.

Phylogenomic databases

eggNOGiCOG0370.
KOiK04759.
OMAiFMAKEVV.
OrthoDBiEOG6JQH16.

Enzyme and pathway databases

BioCyciHPY:HP0687-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003373. Fe2_transport_prot-B.
IPR011640. Fe2_transport_prot_B_C.
IPR011619. Fe2_transport_prot_B_N.
IPR030389. G_FEOB_dom.
IPR011642. Nucleoside_recog_Gate.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11649:SF37. PTHR11649:SF37. 1 hit.
PfamiPF07664. FeoB_C. 1 hit.
PF02421. FeoB_N. 1 hit.
PF07670. Gate. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00437. feoB. 1 hit.
PROSITEiPS51711. G_FEOB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter."
    Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L., Andrews S.C., Kelly D.J.
    Mol. Microbiol. 37:274-286(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.

Entry informationi

Entry nameiFEOB_HELPY
AccessioniPrimary (citable) accession number: O25396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.