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O25396

- FEOB_HELPY

UniProt

O25396 - FEOB_HELPY

Protein

Ferrous iron transport protein B

Gene

feoB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    ATP-driven Fe2+ uptake system.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ferrous iron transmembrane transporter activity Source: InterPro
    3. GTP binding Source: InterPro

    GO - Biological processi

    1. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    ATP-binding, Iron, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0687-MONOMER.

    Protein family/group databases

    TCDBi9.A.8.1.2. the ferrous iron uptake (feob) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferrous iron transport protein B
    Gene namesi
    Name:feoB
    Ordered Locus Names:HP_0687
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Cells are unable to colonize the gastric mucosa of mice.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Ferrous iron transport protein BPRO_0000210830Add
    BLAST

    Proteomic databases

    PRIDEiO25396.

    PTM databases

    PhosSiteiP11071046.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3079N.
    IntActiO25396. 19 interactions.
    MINTiMINT-161005.
    STRINGi85962.HP0687.

    Structurei

    3D structure databases

    ProteinModelPortaliO25396.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei541 – 56121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei586 – 60621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei615 – 63521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 168166FeoB-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. [View classification]PROSITE-ProRule annotation
    Contains 1 FeoB-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0370.
    KOiK04759.
    OMAiKAYKQES.
    OrthoDBiEOG6JQH16.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003373. Fe2_transport_prot-B.
    IPR011640. Fe2_transport_prot_B_C.
    IPR011619. Fe2_transport_prot_B_N.
    IPR011642. Nucleoside_recog_Gate.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF07664. FeoB_C. 1 hit.
    PF02421. FeoB_N. 1 hit.
    PF07670. Gate. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00437. feoB. 1 hit.
    PROSITEiPS51711. G_FEOB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25396-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH    50
    QITIIDLPGT YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL 100
    SAQLLDTNKK MLLALNMWDE AQKEGIKINT EKLSKELGVV CVPTSARSKE 150
    DRLNTELLLD EIVRLYSQNT TNNENIKVPS QSFKESLKYS QSAQRIAQLV 200
    ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL SFLIGGGVQK 250
    ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG 300
    ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT 350
    LQNYNERLIT LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG 400
    AVVALVMAKL LKLSVFKGQT ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL 450
    KKAGTYILVG AILIWFMSQY PKSDAAMKAY KQESLLVNKD TTLSSEAKEE 500
    KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS VSLVTGFMAK 550
    EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF 600
    AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV 642
    Length:642
    Mass (Da):71,423
    Last modified:January 1, 1998 - v1
    Checksum:iD6784C7153E8A3BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07741.1.
    PIRiG64605.
    RefSeqiNP_207481.1. NC_000915.1.
    YP_006934609.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07741; AAD07741; HP_0687.
    GeneIDi13869877.
    898903.
    KEGGiheo:C694_03545.
    hpy:HP0687.
    PATRICi20592659. VBIHelPyl33062_0718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07741.1 .
    PIRi G64605.
    RefSeqi NP_207481.1. NC_000915.1.
    YP_006934609.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3079N.
    IntActi O25396. 19 interactions.
    MINTi MINT-161005.
    STRINGi 85962.HP0687.

    Protein family/group databases

    TCDBi 9.A.8.1.2. the ferrous iron uptake (feob) family.

    PTM databases

    PhosSitei P11071046.

    Proteomic databases

    PRIDEi O25396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07741 ; AAD07741 ; HP_0687 .
    GeneIDi 13869877.
    898903.
    KEGGi heo:C694_03545.
    hpy:HP0687.
    PATRICi 20592659. VBIHelPyl33062_0718.

    Phylogenomic databases

    eggNOGi COG0370.
    KOi K04759.
    OMAi KAYKQES.
    OrthoDBi EOG6JQH16.

    Enzyme and pathway databases

    BioCyci HPY:HP0687-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003373. Fe2_transport_prot-B.
    IPR011640. Fe2_transport_prot_B_C.
    IPR011619. Fe2_transport_prot_B_N.
    IPR011642. Nucleoside_recog_Gate.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF07664. FeoB_C. 1 hit.
    PF02421. FeoB_N. 1 hit.
    PF07670. Gate. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00437. feoB. 1 hit.
    PROSITEi PS51711. G_FEOB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter."
      Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L., Andrews S.C., Kelly D.J.
      Mol. Microbiol. 37:274-286(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
      Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.

    Entry informationi

    Entry nameiFEOB_HELPY
    AccessioniPrimary (citable) accession number: O25396
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3