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O25372

- GATB_HELPY

UniProt

O25372 - GATB_HELPY

Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

Gene

gatB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) By similarity.By similarity

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
    ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (EC:6.3.5.-)
    Short name:
    Asp/Glu-ADT subunit B
    Gene namesi
    Name:gatB
    Ordered Locus Names:HP_0658
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BPRO_0000148794Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.By similarity

    Protein-protein interaction databases

    IntActiO25372. 1 interaction.
    MINTiMINT-4059404.
    STRINGi85962.HP0658.

    Structurei

    3D structure databases

    ProteinModelPortaliO25372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GatB/GatE family. GatB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0064.
    KOiK02434.
    OMAiIIIGLEV.
    OrthoDBiEOG6RJV5B.

    Family and domain databases

    HAMAPiMF_00121. GatB.
    InterProiIPR004413. Apn/Gln-ADT_bsu.
    IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
    IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
    IPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
    [Graphical view]
    PANTHERiPTHR11659. PTHR11659. 1 hit.
    PfamiPF02934. GatB_N. 1 hit.
    PF02637. GatB_Yqey. 1 hit.
    [Graphical view]
    SMARTiSM00845. GatB_Yqey. 1 hit.
    [Graphical view]
    SUPFAMiSSF89095. SSF89095. 1 hit.
    TIGRFAMsiTIGR00133. gatB. 1 hit.
    PROSITEiPS01234. GATB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25372-1 [UniParc]FASTAAdd to Basket

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    MPFEAVIGLE VHVQLNTKTK IFCSCSTSFG ESPNSNTCPV CLGLPGALPV    50
    LNKEVVKKAI QLGTAIEANI NQYSIFARKN YFYPDLPKAY QISQFEVPIV 100
    SDGKLEIDTK EGAKIVRIER AHMEEDAGKN IHEGSYSLVD LNRACTPLLE 150
    IVSKPDMRNS EEAIAYLKKL HAIVRFIGIS DANMQEGNFR CDANVSIRPK 200
    GDEKLYTRVE IKNLNSFRFI AKAIEYEIER QSAAWENGRY NEEVVQETRL 250
    FDTHKGITLS MRNKEESADY RYFKDPDLYP VFIDEKLLKE AQKINELPSA 300
    KKIRYMKDFN LKEDDANLLV SDPLLAQYFE SMLHLGVKAK TSVTWLCVEL 350
    LGRLKAEITL ENCGVSTHML GALAKRIDEG KISGKSAKDV LDKLLEEQGG 400
    DVDALIEQMG LSQVNDTEAI VKVIEEVLKN NADKVLEYKS GKDKLFGFFV 450
    GQAMKNLKGA NPSVVNAILK EKLG 474
    Length:474
    Mass (Da):53,157
    Last modified:May 30, 2000 - v2
    Checksum:i990714A74197B34D
    GO

    Sequence cautioni

    The sequence AAD07723.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07723.1. Different initiation.
    PIRiB64602.
    RefSeqiNP_207452.1. NC_000915.1.
    WP_000982564.1. NC_000915.1.
    YP_006934583.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07723; AAD07723; HP_0658.
    GeneIDi13869851.
    898991.
    KEGGiheo:C694_03405.
    hpy:HP0658.
    PATRICi20592601. VBIHelPyl33062_0689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07723.1 . Different initiation.
    PIRi B64602.
    RefSeqi NP_207452.1. NC_000915.1.
    WP_000982564.1. NC_000915.1.
    YP_006934583.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O25372. 1 interaction.
    MINTi MINT-4059404.
    STRINGi 85962.HP0658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07723 ; AAD07723 ; HP_0658 .
    GeneIDi 13869851.
    898991.
    KEGGi heo:C694_03405.
    hpy:HP0658.
    PATRICi 20592601. VBIHelPyl33062_0689.

    Phylogenomic databases

    eggNOGi COG0064.
    KOi K02434.
    OMAi IIIGLEV.
    OrthoDBi EOG6RJV5B.

    Family and domain databases

    HAMAPi MF_00121. GatB.
    InterProi IPR004413. Apn/Gln-ADT_bsu.
    IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
    IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
    IPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
    [Graphical view ]
    PANTHERi PTHR11659. PTHR11659. 1 hit.
    Pfami PF02934. GatB_N. 1 hit.
    PF02637. GatB_Yqey. 1 hit.
    [Graphical view ]
    SMARTi SM00845. GatB_Yqey. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89095. SSF89095. 1 hit.
    TIGRFAMsi TIGR00133. gatB. 1 hit.
    PROSITEi PS01234. GATB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiGATB_HELPY
    AccessioniPrimary (citable) accession number: O25372
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3