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O25372

- GATB_HELPY

UniProt

O25372 - GATB_HELPY

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Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

Gene
gatB, HP_0658
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation
ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (EC:6.3.5.-)
Short name:
Asp/Glu-ADT subunit B
Gene namesi
Name:gatB
Ordered Locus Names:HP_0658
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BUniRule annotationPRO_0000148794Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits By similarity.UniRule annotation

Protein-protein interaction databases

IntActiO25372. 1 interaction.
MINTiMINT-4059404.
STRINGi85962.HP0658.

Structurei

3D structure databases

ProteinModelPortaliO25372.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0064.
KOiK02434.
OMAiIIIGLEV.
OrthoDBiEOG6RJV5B.

Family and domain databases

HAMAPiMF_00121. GatB.
InterProiIPR004413. Apn/Gln-ADT_bsu.
IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
[Graphical view]
PANTHERiPTHR11659. PTHR11659. 1 hit.
PfamiPF02934. GatB_N. 1 hit.
PF02637. GatB_Yqey. 1 hit.
[Graphical view]
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00133. gatB. 1 hit.
PROSITEiPS01234. GATB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25372-1 [UniParc]FASTAAdd to Basket

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MPFEAVIGLE VHVQLNTKTK IFCSCSTSFG ESPNSNTCPV CLGLPGALPV    50
LNKEVVKKAI QLGTAIEANI NQYSIFARKN YFYPDLPKAY QISQFEVPIV 100
SDGKLEIDTK EGAKIVRIER AHMEEDAGKN IHEGSYSLVD LNRACTPLLE 150
IVSKPDMRNS EEAIAYLKKL HAIVRFIGIS DANMQEGNFR CDANVSIRPK 200
GDEKLYTRVE IKNLNSFRFI AKAIEYEIER QSAAWENGRY NEEVVQETRL 250
FDTHKGITLS MRNKEESADY RYFKDPDLYP VFIDEKLLKE AQKINELPSA 300
KKIRYMKDFN LKEDDANLLV SDPLLAQYFE SMLHLGVKAK TSVTWLCVEL 350
LGRLKAEITL ENCGVSTHML GALAKRIDEG KISGKSAKDV LDKLLEEQGG 400
DVDALIEQMG LSQVNDTEAI VKVIEEVLKN NADKVLEYKS GKDKLFGFFV 450
GQAMKNLKGA NPSVVNAILK EKLG 474
Length:474
Mass (Da):53,157
Last modified:May 30, 2000 - v2
Checksum:i990714A74197B34D
GO

Sequence cautioni

The sequence AAD07723.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07723.1. Different initiation.
PIRiB64602.
RefSeqiNP_207452.1. NC_000915.1.
WP_000982564.1. NC_000915.1.
YP_006934583.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07723; AAD07723; HP_0658.
GeneIDi13869851.
898991.
KEGGiheo:C694_03405.
hpy:HP0658.
PATRICi20592601. VBIHelPyl33062_0689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07723.1 . Different initiation.
PIRi B64602.
RefSeqi NP_207452.1. NC_000915.1.
WP_000982564.1. NC_000915.1.
YP_006934583.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O25372. 1 interaction.
MINTi MINT-4059404.
STRINGi 85962.HP0658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07723 ; AAD07723 ; HP_0658 .
GeneIDi 13869851.
898991.
KEGGi heo:C694_03405.
hpy:HP0658.
PATRICi 20592601. VBIHelPyl33062_0689.

Phylogenomic databases

eggNOGi COG0064.
KOi K02434.
OMAi IIIGLEV.
OrthoDBi EOG6RJV5B.

Family and domain databases

HAMAPi MF_00121. GatB.
InterProi IPR004413. Apn/Gln-ADT_bsu.
IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
[Graphical view ]
PANTHERi PTHR11659. PTHR11659. 1 hit.
Pfami PF02934. GatB_N. 1 hit.
PF02637. GatB_Yqey. 1 hit.
[Graphical view ]
SMARTi SM00845. GatB_Yqey. 1 hit.
[Graphical view ]
SUPFAMi SSF89095. SSF89095. 1 hit.
TIGRFAMsi TIGR00133. gatB. 1 hit.
PROSITEi PS01234. GATB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGATB_HELPY
AccessioniPrimary (citable) accession number: O25372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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