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Protein

GlutamylGlutaminyl-tRNA synthetase

Gene

gltX2

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Aminoacylates tRNA(Gln) with glutamate. Does not aminoacylate tRNA(Glu).2 Publications

Catalytic activityi

ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei235 – 2351ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0643-MONOMER.
BRENDAi6.1.1.24. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutamylGlutaminyl-tRNA synthetase (EC:6.1.1.-)
Short name:
GluGlnRS
Alternative name(s):
Glutamate--tRNA ligase 2
Short name:
GluRS 2
Glutamyl-tRNA synthetase 2
Gene namesi
Name:gltX2
Ordered Locus Names:HP_0643
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439GlutamylGlutaminyl-tRNA synthetasePRO_0000119577Add
BLAST

Proteomic databases

PaxDbiO25360.
PRIDEiO25360.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

DIPiDIP-3622N.
IntActiO25360. 2 interactions.
MINTiMINT-168508.
STRINGi85962.HP0643.

Structurei

3D structure databases

ProteinModelPortaliO25360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 1611"HIGH" regionAdd
BLAST
Motifi232 – 2365"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C20. Bacteria.
COG0008. LUCA.
KOiK01885.
OMAiRVAIFNY.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B. 1 hit.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFAPSPTG DMHIGNLRAA IFNYIVAKQQ YKPFLIRIED TDKERNIEGK
60 70 80 90 100
DQEILEILKL MGISWDKLVY QSHNIDYHRE MAEKLLKENK AFYCYASAEF
110 120 130 140 150
LEREKEKAKN EKRPFRYSDE WATLEKDKHH APVVRLKAPN HAVSFNDAIK
160 170 180 190 200
KEVKFEPDEL DSFVLLRQDK SPTYNFACAC DDLLYKISLI IRGEDHVSNT
210 220 230 240 250
PKQILIQQAL GSNDPIVYAH LPIILDEVSG KKMSKRDEAS SVKWLLNQGF
260 270 280 290 300
LPVAIANYLI TIGNKVPKEV FSLDEAIEWF SLENLSSSPA HFNLKYLKHL
310 320 330 340 350
NHEHLKLLDD DKLLELTSIK DKNLLGLLRL FIEECGTLLE LREKISLFLE
360 370 380 390 400
PKDIVKTYEN EDFKERCLAL FNALTSMDFQ AYKDFESFKK EAMRLSQLKG
410 420 430
KDFFKPLRIL LTGNSHGVEL PLIFPYIQSH HQEVLRLKA
Length:439
Mass (Da):51,003
Last modified:January 1, 1998 - v1
Checksum:i9819BA3C49F60C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07704.1.
PIRiC64600.
RefSeqiNP_207437.1. NC_000915.1.
WP_000943321.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07704; AAD07704; HP_0643.
GeneIDi900020.
KEGGihpy:HP0643.
PATRICi20592571. VBIHelPyl33062_0674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07704.1.
PIRiC64600.
RefSeqiNP_207437.1. NC_000915.1.
WP_000943321.1. NC_000915.1.

3D structure databases

ProteinModelPortaliO25360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3622N.
IntActiO25360. 2 interactions.
MINTiMINT-168508.
STRINGi85962.HP0643.

Proteomic databases

PaxDbiO25360.
PRIDEiO25360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07704; AAD07704; HP_0643.
GeneIDi900020.
KEGGihpy:HP0643.
PATRICi20592571. VBIHelPyl33062_0674.

Phylogenomic databases

eggNOGiENOG4105C20. Bacteria.
COG0008. LUCA.
KOiK01885.
OMAiRVAIFNY.

Enzyme and pathway databases

BioCyciHPY:HP0643-MONOMER.
BRENDAi6.1.1.24. 2604.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B. 1 hit.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYE2_HELPY
AccessioniPrimary (citable) accession number: O25360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.