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O25360 (SYE2_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GlutamylGlutaminyl-tRNA synthetase
Short name=GluGlnRS
EC=6.1.1.-
Alternative name(s):
Glutamate--tRNA ligase 2
Short name=GluRS 2
Glutamyl-tRNA synthetase 2
Gene names
Name:gltX2
Ordered Locus Names:HP_0643
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Aminoacylates tRNA(Gln) with glutamate. Does not aminoacylate tRNA(Glu). Ref.2 Ref.3

Catalytic activity

ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln). HAMAP MF_00022_B

Subunit structure

Monomer By similarity. HAMAP MF_00022_B

Subcellular location

Cytoplasm HAMAP MF_00022_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439GlutamylGlutaminyl-tRNA synthetase HAMAP MF_00022_B
PRO_0000119577

Regions

Motif6 – 1611"HIGH" region HAMAP MF_00022_B
Motif232 – 2365"KMSKS" region HAMAP MF_00022_B

Sites

Binding site2351ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O25360 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9819BA3C49F60C9A

FASTA43951,003
        10         20         30         40         50         60 
MLRFAPSPTG DMHIGNLRAA IFNYIVAKQQ YKPFLIRIED TDKERNIEGK DQEILEILKL 

        70         80         90        100        110        120 
MGISWDKLVY QSHNIDYHRE MAEKLLKENK AFYCYASAEF LEREKEKAKN EKRPFRYSDE 

       130        140        150        160        170        180 
WATLEKDKHH APVVRLKAPN HAVSFNDAIK KEVKFEPDEL DSFVLLRQDK SPTYNFACAC 

       190        200        210        220        230        240 
DDLLYKISLI IRGEDHVSNT PKQILIQQAL GSNDPIVYAH LPIILDEVSG KKMSKRDEAS 

       250        260        270        280        290        300 
SVKWLLNQGF LPVAIANYLI TIGNKVPKEV FSLDEAIEWF SLENLSSSPA HFNLKYLKHL 

       310        320        330        340        350        360 
NHEHLKLLDD DKLLELTSIK DKNLLGLLRL FIEECGTLLE LREKISLFLE PKDIVKTYEN 

       370        380        390        400        410        420 
EDFKERCLAL FNALTSMDFQ AYKDFESFKK EAMRLSQLKG KDFFKPLRIL LTGNSHGVEL 

       430 
PLIFPYIQSH HQEVLRLKA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07704.1.
PIRC64600.
RefSeqNP_207437.1. NC_000915.1.

3D structure databases

ProteinModelPortalO25360.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3622N.
MINTMINT-168508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID900020.
GenomeReviewsGene locus HP_0643 in contig AE000511_GR.
KEGGhpy:HP0643.
NMPDRfig|85962.1.peg.635.
PATRIC20592571. VBIHelPyl33062_0674.
TIGRHP_0643.

Phylogenomic databases

HOGENOMHBG628189.
OMASVKWLLN.
ProtClustDBPRK12410.

Family and domain databases

HAMAPMF_00022_B. Glu_tRNA_synth_B. Divergent sequence.
[Tree]
InterProIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-synth_Ib_bac/mito.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
G3DSA:1.10.10.350. tRNA_synt_bd. 1 hit.
KOK01885.
PANTHERPTHR10119. Glu_tRNA-synt_1c. 1 hit.
PTHR10119:SF1. PTHR10119:SF1. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF48163. tRNA-synt_bind. 1 hit.
TIGRFAMsTIGR00464. GltX_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYE2_HELPY
AccessionPrimary (citable) accession number: O25360
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents