O25348 (O25348_HELPY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Quinone-reactive Ni/Fe hydrogenase, small subunit (HydA) EMBL AAD07691.1

Gene names

Ordered Locus Names:

HP_0631

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 3Fe-4S cluster By similarity. PIRSR PIRSR000310-1 Binds 2 4Fe-4S clusters By similarity. PIRSR PIRSR000310-1

Ontologies

Keywords
Ligand	3Fe-4S PIRSR PIRSR000310-1 4Fe-4S PIRSR PIRSR000310-1 Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	ferredoxin hydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	86	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	89	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	185	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	218	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	256	1	Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity PIRSR PIRSR000310-1
	Metal binding	259	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	284	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	290	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	299	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	318	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	321	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1

Sequences

	Sequence		Length	Mass (Da)
	O25348 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 70B794CE70CB2F46	FASTA	384	42,354
	10 20 30 40 50 60 MFYDEKKTYQ KIEERLDIVR SFNAHNEHKN LQDEFKGAGI SRRDLLKWAG MMSTALALPA 70 80 90 100 110 120 SFAPLTLKAV EVANRLPVIW LHMAECTGCS ESLLRSADPT IDSIIFDYIN LEYHETIMVA 130 140 150 160 170 180 SGFQAEKSLH DAIEKHKNNY ILMVEGGIPQ GTEYFLTQGP NAETGAEECR KAAQYAAAIF 190 200 210 220 230 240 AIGTCSSFGG VQAAYPNPSN AQPLHKIIDK PVINVPGCPP SEKNIVGNVL YYLMFGALPK 250 260 270 280 290 300 LDAYNRPSWA YGNRIHDLCE RRGHFDAGEF VEHFGDENAK RGFCLYKMGC KGPYTFNNCS 310 320 330 340 350 360 KLRFNSHTSW PIGAGHGCIG CSEPNFWDTM SPFEEPLANR SIKTAFDGLG ADKVADKVGT 370 380 TLLSATAIGI VAHALLSKAI KNKE

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07691.1.
PIR	G64598.
RefSeq	NP_207425.1. NC_000915.1.
3D structure databases
HSSP	HSSP built from PDB template 1FRF based on UniProtKB P18187.
ProteinModelPortal	O25348.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899296.
GenomeReviews	Gene locus HP_0631 in contig AE000511_GR.
KEGG	hpy:HP0631.
NMPDR	fig|85962.1.peg.623.
PATRIC	20592545. VBIHelPyl33062_0661.
TIGR	HP_0631.
Phylogenomic databases
HOGENOM	HBG575615.
OMA	LEYHETV.
ProtClustDB	CLSK872400.
Family and domain databases
InterPro	IPR006137. NADH_UbQ_OxRdtase-like_20kDa. IPR001821. NiFe_hydrogenase_ssu. IPR006311. TAT_signal. [Graphical view]
Gene3D	G3DSA:3.40.50.700. G3DSA:3.40.50.700. 1 hit.
KO	K05927.
Pfam	PF01058. Oxidored_q6. 1 hit. [Graphical view]
PIRSF	PIRSF000310. NiFe_hyd_ssu. 1 hit.
PRINTS	PR00614. NIHGNASESMLL.
TIGRFAMs	TIGR00391. HydA. 1 hit.
PROSITE	PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O25348_HELPY

Accession

Primary (citable) accession number: O25348

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)