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Protein
Submitted name:

Acriflavine resistance protein (AcrB)

Gene

HP_0607

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP0607-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Acriflavine resistance protein (AcrB)Imported
Gene namesi
Ordered Locus Names:HP_0607Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei327 – 344HelicalSequence analysisAdd BLAST18
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei377 – 401HelicalSequence analysisAdd BLAST25
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei454 – 481HelicalSequence analysisAdd BLAST28
Transmembranei515 – 532HelicalSequence analysisAdd BLAST18
Transmembranei855 – 874HelicalSequence analysisAdd BLAST20
Transmembranei881 – 901HelicalSequence analysisAdd BLAST21
Transmembranei907 – 932HelicalSequence analysisAdd BLAST26
Transmembranei953 – 972HelicalSequence analysisAdd BLAST20
Transmembranei984 – 1010HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO25328.
PRIDEiO25328.

Interactioni

Protein-protein interaction databases

DIPiDIP-3094N.
IntActiO25328. 5 interactors.
MINTiMINT-179120.
STRINGi85962.HP0607.

Structurei

3D structure databases

ProteinModelPortaliO25328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 479SSD (sterol-sensing)InterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
KOiK03296.
OMAiVEGANYR.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR000731. SSD.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTAINRPI TTLMFALAIV FFGTMGFKKL SVALFPKIDL PTVVVTTTYP
60 70 80 90 100
GASAEIIESK VTDKIEEAVM GIDGIKKVTS TSSKNVSIVV IEFELEKPNE
110 120 130 140 150
EALNDVVNKI SSVRFDDSNI KKPSINKFDT DSQAIISLFV SSSSVPATTL
160 170 180 190 200
NDYAKNTIKP MLQKINGVGG VQLNGFRERQ IRIYANPTLM NKYNLTYADL
210 220 230 240 250
FSTLKAENVE IDGGRIVNSQ REFSILINAN SYSVADVEKI QVGNHVRLGD
260 270 280 290 300
IAKIEIGLEE DNTFASFKDK PGVILEIQKI AGANEIEIVD RVYEALKRIQ
310 320 330 340 350
AISPNYEIRP FLDTTGYIRT SIEDVKFDLV LGAILAVLVV FAFLRNGTIT
360 370 380 390 400
LVSAISIPIS IMGTFALIQW MGFSLNMLTM VALTLAIGII IDDAIVVIEN
410 420 430 440 450
IHKKLEMGMS KRKASYEGVR EIGFALVAIS AMLLSVFVPI GNMKGIIGRF
460 470 480 490 500
FQSFGITVAL AIALSYVVVV TIIPMVSSVV VNPRHSRFYV WSEPFFKALE
510 520 530 540 550
SRYTKLLQWV LNHKIIISIA VVLVFVGSLF VASKIGMEFM LKEDRGRFLV
560 570 580 590 600
WLKAKPGVSI DYMTQKSKIF QKAIEKHAEV EFTTLQVGYG TTQNPFKAKI
610 620 630 640 650
FVQLKPLKER KKEHQLGQFE LMSVLRKELR SLPEAKGLDT INLSEVTLIG
660 670 680 690 700
GGGDSSPFQT FVFSHSQEAV DKSVENLKKF LLESPELKGK VESYHTSTSE
710 720 730 740 750
SQPQLQLKIL RQNANKYGVS AQTIGSVVSS AFSGTSQASV FKEDGKEYDM
760 770 780 790 800
IIRVPDDKRV SVEDIKRLQV RNKYDKLMFL DALVEITETK SPSSISRYNR
810 820 830 840 850
QRSVTVLAEP NRNAGVSLGE ILTQVSKNTK EWLVEGANYR FTGEADNAKE
860 870 880 890 900
SNGEFLVALA TAFVLIYMIL AALYESILEP FIIMVTMPLS FSGAFFALGL
910 920 930 940 950
VHQPLSMFSM IGLILLIGMV GKNATLLIDV ANEERKKGLN IQEAILFAGK
960 970 980 990 1000
TRLRPILMTT IAMVCGMLPL ALASGDGAAM KSPIGIAMSG GLMISMVLSL
1010 1020
LIVPVFYRLL APIDDKIKRF YQNQKTLE
Length:1,028
Mass (Da):113,740
Last modified:January 1, 1998 - v1
Checksum:i7CD2BCD735A70936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07671.1.
PIRiG64595.
RefSeqiNP_207402.1. NC_000915.1.
WP_000278421.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07671; AAD07671; HP_0607.
GeneIDi900026.
KEGGiheo:C694_03140.
hpy:HP0607.
PATRICi20592493. VBIHelPyl33062_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07671.1.
PIRiG64595.
RefSeqiNP_207402.1. NC_000915.1.
WP_000278421.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3094N.
IntActiO25328. 5 interactors.
MINTiMINT-179120.
STRINGi85962.HP0607.

Proteomic databases

PaxDbiO25328.
PRIDEiO25328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07671; AAD07671; HP_0607.
GeneIDi900026.
KEGGiheo:C694_03140.
hpy:HP0607.
PATRICi20592493. VBIHelPyl33062_0635.

Phylogenomic databases

eggNOGiENOG4105BZS. Bacteria.
COG0841. LUCA.
KOiK03296.
OMAiVEGANYR.

Enzyme and pathway databases

BioCyciHPY:HP0607-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR000731. SSD.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO25328_HELPY
AccessioniPrimary (citable) accession number: O25328
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.