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Protein
Submitted name:

Uncharacterized protein

Gene

HP_0596

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciHPY:HP0596-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:HP_0596Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0596.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WCQX-ray1.90A/B34-192[»]
2WCRX-ray1.70A/B34-192[»]
3GIOX-ray2.40A/B28-192[»]
3GUQX-ray2.47A28-192[»]
3VNCX-ray2.60A/B25-192[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OMAiKMSLDNQ.
OrthoDBiEOG6K9QGV.

Sequencei

Sequence statusi: Complete.

O25318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEKSFLKSK QLFLCGLGVL MLQACTCPNT SQRNSFLQDV PYWMLQNRSE
60 70 80 90 100
YITQGVDSSH IVDGKKTEEI EKIATKRATI RVAQNIVHKL KEAYLSKTNR
110 120 130 140 150
IKQKITNEMF IQMTQPIYDS LMNVDRLGIY INPNNEEVFA LVRARGFDKD
160 170 180 190
ALSEGLHKMS LDNQAVSILV AKVEEIFKDS VNYGDVKVPI AM
Length:192
Mass (Da):21,878
Last modified:January 1, 1998 - v1
Checksum:iF643AFD91293D9CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1.
PIRiD64594.
RefSeqiNP_207391.1. NC_000915.1.
WP_000890837.1. NC_018939.1.
YP_006934520.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07665; AAD07665; HP_0596.
AFV41817; AFV41817; C694_03080.
GeneIDi898978.
KEGGiheo:C694_03080.
hpy:HP0596.
PATRICi20592471. VBIHelPyl33062_0624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1.
PIRiD64594.
RefSeqiNP_207391.1. NC_000915.1.
WP_000890837.1. NC_018939.1.
YP_006934520.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WCQX-ray1.90A/B34-192[»]
2WCRX-ray1.70A/B34-192[»]
3GIOX-ray2.40A/B28-192[»]
3GUQX-ray2.47A28-192[»]
3VNCX-ray2.60A/B25-192[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07665; AAD07665; HP_0596.
AFV41817; AFV41817; C694_03080.
GeneIDi898978.
KEGGiheo:C694_03080.
hpy:HP0596.
PATRICi20592471. VBIHelPyl33062_0624.

Phylogenomic databases

OMAiKMSLDNQ.
OrthoDBiEOG6K9QGV.

Enzyme and pathway databases

BioCyciHPY:HP0596-MONOMER.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695Imported.
  2. "Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein."
    Tsuge H., Tsurumura T., Utsunomiya H., Kise D., Kuzuhara T., Watanabe T., Fujiki H., Suganuma M.
    Biochem. Biophys. Res. Commun. 388:193-198(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 28-192.
  3. "Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori."
    Tosi T., Cioci G., Jouravleva K., Dian C., Terradot L.
    FEBS Lett. 583:1581-1585(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 34-192.
  4. "Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity."
    Jang J.Y., Yoon H.J., Yoon J.Y., Kim H.S., Lee S.J., Kim K.H., Kim d.o. .J., Jang S., Han B.G., Lee B.I., Suh S.W.
    J. Mol. Biol. 392:191-197(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 28-192.
  5. "Crystal structure of TNF-alpha-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding."
    Gao M., Li D., Hu Y., Zhang Y., Zou Q., Wang D.C.
    PLoS ONE 7:e41871-e41871(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-192.

Entry informationi

Entry nameiO25318_HELPY
AccessioniPrimary (citable) accession number: O25318
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.