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O25318

- O25318_HELPY

UniProt

O25318 - O25318_HELPY

Protein
Submitted name:

Tumor necrosis factor alpha-inducing protein

Gene

C694_03080

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601CitrateImported
    Binding sitei77 – 771CitrateImported

    Enzyme and pathway databases

    BioCyciHPY:HP0596-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tumor necrosis factor alpha-inducing proteinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Ordered Locus Names:C694_03080Imported, HP_0596Imported
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000010112: Chromosome, UP000000429: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0596.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WCQX-ray1.90A/B34-192[»]
    2WCRX-ray1.70A/B34-192[»]
    3GIOX-ray2.40A/B28-192[»]
    3GUQX-ray2.47A28-192[»]
    3VNCX-ray2.60A/B25-192[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO25318.

    Family & Domainsi

    Phylogenomic databases

    OMAiKMSLDNQ.
    OrthoDBiEOG6K9QGV.

    Sequencei

    Sequence statusi: Complete.

    O25318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEKSFLKSK QLFLCGLGVL MLQACTCPNT SQRNSFLQDV PYWMLQNRSE    50
    YITQGVDSSH IVDGKKTEEI EKIATKRATI RVAQNIVHKL KEAYLSKTNR 100
    IKQKITNEMF IQMTQPIYDS LMNVDRLGIY INPNNEEVFA LVRARGFDKD 150
    ALSEGLHKMS LDNQAVSILV AKVEEIFKDS VNYGDVKVPI AM 192
    Length:192
    Mass (Da):21,878
    Last modified:January 1, 1998 - v1
    Checksum:iF643AFD91293D9CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07665.1.
    CP003904 Genomic DNA. Translation: AFV41817.1.
    PIRiD64594.
    RefSeqiNP_207391.1. NC_000915.1.
    YP_006934520.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07665; AAD07665; HP_0596.
    AFV41817; AFV41817; C694_03080.
    GeneIDi13869788.
    898978.
    KEGGiheo:C694_03080.
    hpy:HP0596.
    PATRICi20592471. VBIHelPyl33062_0624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07665.1 .
    CP003904 Genomic DNA. Translation: AFV41817.1 .
    PIRi D64594.
    RefSeqi NP_207391.1. NC_000915.1.
    YP_006934520.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WCQ X-ray 1.90 A/B 34-192 [» ]
    2WCR X-ray 1.70 A/B 34-192 [» ]
    3GIO X-ray 2.40 A/B 28-192 [» ]
    3GUQ X-ray 2.47 A 28-192 [» ]
    3VNC X-ray 2.60 A/B 25-192 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07665 ; AAD07665 ; HP_0596 .
    AFV41817 ; AFV41817 ; C694_03080 .
    GeneIDi 13869788.
    898978.
    KEGGi heo:C694_03080.
    hpy:HP0596.
    PATRICi 20592471. VBIHelPyl33062_0624.

    Phylogenomic databases

    OMAi KMSLDNQ.
    OrthoDBi EOG6K9QGV.

    Enzyme and pathway databases

    BioCyci HPY:HP0596-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O25318.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 26695Imported and ATCC 700392 / 26695Imported.
    2. White O.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 26695.
    3. "Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein."
      Tsuge H., Tsurumura T., Utsunomiya H., Kise D., Kuzuhara T., Watanabe T., Fujiki H., Suganuma M.
      Biochem. Biophys. Res. Commun. 388:193-198(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 28-192.
    4. "Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori."
      Tosi T., Cioci G., Jouravleva K., Dian C., Terradot L.
      FEBS Lett. 583:1581-1585(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 34-192.
    5. "Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity."
      Jang J.Y., Yoon H.J., Yoon J.Y., Kim H.S., Lee S.J., Kim K.H., Kim d.o. .J., Jang S., Han B.G., Lee B.I., Suh S.W.
      J. Mol. Biol. 392:191-197(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 28-192.
    6. "Crystal structure of TNF-?-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding."
      Gao M., Li D., Hu Y., Zhang Y., Zou Q., Wang D.C.
      PLoS ONE 7:e41871-e41871(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-192.
    7. "Draft genome of Helicobacter pylori."
      Chelysheva V., Selezneva O., Alexeev D., Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Kostryukova E., Govorun V., Momynaliev K.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 26695Imported.
    8. "Draft genome of Helicobacter pylori."
      Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D., Kostrjukova E., Govorun V.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695Imported.

    Entry informationi

    Entry nameiO25318_HELPY
    AccessioniPrimary (citable) accession number: O25318
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3