SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O25318

- O25318_HELPY

UniProt

O25318 - O25318_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Tumor necrosis factor alpha-inducing protein
Gene
C694_03080, HP_0596
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601CitrateImported
Binding sitei77 – 771CitrateImported

Enzyme and pathway databases

BioCyciHPY:HP0596-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alpha-inducing proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:C694_03080Imported, HP_0596Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000010112: Chromosome, UP000000429: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0596.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WCQX-ray1.90A/B34-192[»]
2WCRX-ray1.70A/B34-192[»]
3GIOX-ray2.40A/B28-192[»]
3GUQX-ray2.47A28-192[»]
3VNCX-ray2.60A/B25-192[»]

Miscellaneous databases

EvolutionaryTraceiO25318.

Family & Domainsi

Phylogenomic databases

OMAiKMSLDNQ.
OrthoDBiEOG6K9QGV.

Sequencei

Sequence statusi: Complete.

O25318-1 [UniParc]FASTAAdd to Basket

« Hide

MLEKSFLKSK QLFLCGLGVL MLQACTCPNT SQRNSFLQDV PYWMLQNRSE    50
YITQGVDSSH IVDGKKTEEI EKIATKRATI RVAQNIVHKL KEAYLSKTNR 100
IKQKITNEMF IQMTQPIYDS LMNVDRLGIY INPNNEEVFA LVRARGFDKD 150
ALSEGLHKMS LDNQAVSILV AKVEEIFKDS VNYGDVKVPI AM 192
Length:192
Mass (Da):21,878
Last modified:January 1, 1998 - v1
Checksum:iF643AFD91293D9CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1.
CP003904 Genomic DNA. Translation: AFV41817.1.
PIRiD64594.
RefSeqiNP_207391.1. NC_000915.1.
YP_006934520.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07665; AAD07665; HP_0596.
AFV41817; AFV41817; C694_03080.
GeneIDi13869788.
898978.
KEGGiheo:C694_03080.
hpy:HP0596.
PATRICi20592471. VBIHelPyl33062_0624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1 .
CP003904 Genomic DNA. Translation: AFV41817.1 .
PIRi D64594.
RefSeqi NP_207391.1. NC_000915.1.
YP_006934520.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WCQ X-ray 1.90 A/B 34-192 [» ]
2WCR X-ray 1.70 A/B 34-192 [» ]
3GIO X-ray 2.40 A/B 28-192 [» ]
3GUQ X-ray 2.47 A 28-192 [» ]
3VNC X-ray 2.60 A/B 25-192 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07665 ; AAD07665 ; HP_0596 .
AFV41817 ; AFV41817 ; C694_03080 .
GeneIDi 13869788.
898978.
KEGGi heo:C694_03080.
hpy:HP0596.
PATRICi 20592471. VBIHelPyl33062_0624.

Phylogenomic databases

OMAi KMSLDNQ.
OrthoDBi EOG6K9QGV.

Enzyme and pathway databases

BioCyci HPY:HP0596-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25318.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 26695Imported and ATCC 700392 / 26695.
  2. White O.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695.
  3. "Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein."
    Tsuge H., Tsurumura T., Utsunomiya H., Kise D., Kuzuhara T., Watanabe T., Fujiki H., Suganuma M.
    Biochem. Biophys. Res. Commun. 388:193-198(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 28-192.
  4. "Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori."
    Tosi T., Cioci G., Jouravleva K., Dian C., Terradot L.
    FEBS Lett. 583:1581-1585(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 34-192.
  5. "Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity."
    Jang J.Y., Yoon H.J., Yoon J.Y., Kim H.S., Lee S.J., Kim K.H., Kim d.o. .J., Jang S., Han B.G., Lee B.I., Suh S.W.
    J. Mol. Biol. 392:191-197(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 28-192.
  6. "Crystal structure of TNF-?-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding."
    Gao M., Li D., Hu Y., Zhang Y., Zou Q., Wang D.C.
    PLoS ONE 7:e41871-e41871(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-192.
  7. "Draft genome of Helicobacter pylori."
    Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D., Kostrjukova E., Govorun V.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  8. "Draft genome of Helicobacter pylori."
    Chelysheva V., Selezneva O., Alexeev D., Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Kostryukova E., Govorun V., Momynaliev K.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695Imported.

Entry informationi

Entry nameiO25318_HELPY
AccessioniPrimary (citable) accession number: O25318
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi