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O25318

- O25318_HELPY

UniProt

O25318 - O25318_HELPY

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Protein
Submitted name:

Tumor necrosis factor alpha-inducing protein

Gene

C694_03080

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601CitrateImported
Binding sitei77 – 771CitrateImported

Enzyme and pathway databases

BioCyciHPY:HP0596-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alpha-inducing proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:C694_03080Imported, HP_0596Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome, UP000010112: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0596.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WCQX-ray1.90A/B34-192[»]
2WCRX-ray1.70A/B34-192[»]
3GIOX-ray2.40A/B28-192[»]
3GUQX-ray2.47A28-192[»]
3VNCX-ray2.60A/B25-192[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25318.

Family & Domainsi

Phylogenomic databases

OMAiKMSLDNQ.
OrthoDBiEOG6K9QGV.

Sequencei

Sequence statusi: Complete.

O25318 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKSFLKSK QLFLCGLGVL MLQACTCPNT SQRNSFLQDV PYWMLQNRSE
60 70 80 90 100
YITQGVDSSH IVDGKKTEEI EKIATKRATI RVAQNIVHKL KEAYLSKTNR
110 120 130 140 150
IKQKITNEMF IQMTQPIYDS LMNVDRLGIY INPNNEEVFA LVRARGFDKD
160 170 180 190
ALSEGLHKMS LDNQAVSILV AKVEEIFKDS VNYGDVKVPI AM
Length:192
Mass (Da):21,878
Last modified:January 1, 1998 - v1
Checksum:iF643AFD91293D9CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1.
CP003904 Genomic DNA. Translation: AFV41817.1.
PIRiD64594.
RefSeqiNP_207391.1. NC_000915.1.
YP_006934520.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07665; AAD07665; HP_0596.
AFV41817; AFV41817; C694_03080.
GeneIDi13869788.
898978.
KEGGiheo:C694_03080.
hpy:HP0596.
PATRICi20592471. VBIHelPyl33062_0624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07665.1 .
CP003904 Genomic DNA. Translation: AFV41817.1 .
PIRi D64594.
RefSeqi NP_207391.1. NC_000915.1.
YP_006934520.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WCQ X-ray 1.90 A/B 34-192 [» ]
2WCR X-ray 1.70 A/B 34-192 [» ]
3GIO X-ray 2.40 A/B 28-192 [» ]
3GUQ X-ray 2.47 A 28-192 [» ]
3VNC X-ray 2.60 A/B 25-192 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07665 ; AAD07665 ; HP_0596 .
AFV41817 ; AFV41817 ; C694_03080 .
GeneIDi 13869788.
898978.
KEGGi heo:C694_03080.
hpy:HP0596.
PATRICi 20592471. VBIHelPyl33062_0624.

Phylogenomic databases

OMAi KMSLDNQ.
OrthoDBi EOG6K9QGV.

Enzyme and pathway databases

BioCyci HPY:HP0596-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25318.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 26695Imported and ATCC 700392 / 26695Imported.
  2. White O.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695.
  3. "Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein."
    Tsuge H., Tsurumura T., Utsunomiya H., Kise D., Kuzuhara T., Watanabe T., Fujiki H., Suganuma M.
    Biochem. Biophys. Res. Commun. 388:193-198(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 28-192.
  4. "Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori."
    Tosi T., Cioci G., Jouravleva K., Dian C., Terradot L.
    FEBS Lett. 583:1581-1585(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 34-192.
  5. "Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity."
    Jang J.Y., Yoon H.J., Yoon J.Y., Kim H.S., Lee S.J., Kim K.H., Kim d.o. .J., Jang S., Han B.G., Lee B.I., Suh S.W.
    J. Mol. Biol. 392:191-197(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 28-192.
  6. "Crystal structure of TNF-?-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding."
    Gao M., Li D., Hu Y., Zhang Y., Zou Q., Wang D.C.
    PLoS ONE 7:e41871-e41871(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-192.
  7. "Draft genome of Helicobacter pylori."
    Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D., Kostrjukova E., Govorun V.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695Imported.
  8. "Draft genome of Helicobacter pylori."
    Chelysheva V., Selezneva O., Alexeev D., Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Kostryukova E., Govorun V., Momynaliev K.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695Imported.

Entry informationi

Entry nameiO25318_HELPY
AccessioniPrimary (citable) accession number: O25318
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3