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Protein

Signal peptidase I

Gene

lepB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381By similarity
Active sitei106 – 1061By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciHPY:HP0576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:HP_0576
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 290256ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Signal peptidase IPRO_0000109508Add
BLAST

Proteomic databases

PaxDbiO25300.
PRIDEiO25300.

Interactioni

Protein-protein interaction databases

IntActiO25300. 2 interactions.
STRINGi85962.HP0576.

Structurei

3D structure databases

ProteinModelPortaliO25300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3F. Bacteria.
COG0681. LUCA.
KOiK03100.
OMAiAFIIPSR.
OrthoDBiEOG6KDKTM.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 3 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLRSVYAF CSSWVGTIVI VLLVIFFIAQ AFIIPSRSMV GTLYEGDMLF
60 70 80 90 100
VKKFSYGIPI PKIPWIELPV MPDFKNNGHL IEGDRPKRGE VVVFIPPHEK
110 120 130 140 150
KSYYVKRNFA IGGDEVLFTN EGFYLHPFES DTDKNYIAKH YPNAMTKEFM
160 170 180 190 200
GKIFVLNPYK NEHPGIHYQK DNETFHLMEQ LATQGAEANI SMQLIQMEGE
210 220 230 240 250
KVFYKKINDD EFFMIGDNRD NSSDSRFWGS VAYKNIVGSP WFVYFSLSLK
260 270 280 290
NSLEMDAENN PKKRYLVRWE RMFKSVGGLE KIIKKENATH
Length:290
Mass (Da):33,710
Last modified:January 1, 1998 - v1
Checksum:iF3DF2DFCE8465310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07643.1.
PIRiH64591.
RefSeqiNP_207371.1. NC_000915.1.
WP_000670710.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07643; AAD07643; HP_0576.
GeneIDi899281.
KEGGiheo:C694_02970.
hpy:HP0576.
PATRICi20592425. VBIHelPyl33062_0601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07643.1.
PIRiH64591.
RefSeqiNP_207371.1. NC_000915.1.
WP_000670710.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25300. 2 interactions.
STRINGi85962.HP0576.

Proteomic databases

PaxDbiO25300.
PRIDEiO25300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07643; AAD07643; HP_0576.
GeneIDi899281.
KEGGiheo:C694_02970.
hpy:HP0576.
PATRICi20592425. VBIHelPyl33062_0601.

Phylogenomic databases

eggNOGiENOG4105C3F. Bacteria.
COG0681. LUCA.
KOiK03100.
OMAiAFIIPSR.
OrthoDBiEOG6KDKTM.

Enzyme and pathway databases

BioCyciHPY:HP0576-MONOMER.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 3 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiLEP_HELPY
AccessioniPrimary (citable) accession number: O25300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.