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O25290

- DAPF_HELPY

UniProt

O25290 - DAPF_HELPY

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei42 – 421SubstrateUniRule annotation
    Binding sitei60 – 601SubstrateUniRule annotation
    Active sitei69 – 691Proton donor/acceptorUniRule annotation
    Sitei152 – 1521Important for catalytic activityUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Sitei199 – 1991Important for catalytic activityUniRule annotation
    Active sitei209 – 2091Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciHPY:HP0566-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:HP_0566
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Diaminopimelate epimerasePRO_0000149843Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 209

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO25290.

    Interactioni

    Protein-protein interaction databases

    IntActiO25290. 2 interactions.
    STRINGi85962.HP0566.

    Structurei

    3D structure databases

    ProteinModelPortaliO25290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 713Substrate bindingUniRule annotation
    Regioni199 – 2002Substrate bindingUniRule annotation
    Regioni210 – 2112Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    KOiK01778.
    OMAiINTGSPH.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25290-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFYKYSGSG NDFLIVQSFK KKDFSNLAKQ VCHRHEGFGA DGLVVVLPSK    50
    DYDYEWDFYN SDGSKAGMCG NASRCVGLFA YQHAIASKNH VFLAGKREIS 100
    ICIEEPNIIE SNLGNYKILD VIPALRCEKF FSSGSVLEHI PTFYLIDTGV 150
    PHLVGFVENK EGLNSLNTLE LRALRHEFNA NINIAFIENK ETIFLQTYER 200
    GVEDFTLACG TGMAAVFIAA RIFYNTPKKA ALIPKSNESL ELSLKNDGIF 250
    YKGAVRYIGM SVLGMRVFEN GCF 273
    Length:273
    Mass (Da):30,500
    Last modified:January 1, 1998 - v1
    Checksum:i73F3D7917AD35ACD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07622.1.
    PIRiF64590.
    RefSeqiNP_207361.1. NC_000915.1.
    YP_006934488.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07622; AAD07622; HP_0566.
    GeneIDi13869756.
    899009.
    KEGGiheo:C694_02920.
    hpy:HP0566.
    PATRICi20592405. VBIHelPyl33062_0591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07622.1 .
    PIRi F64590.
    RefSeqi NP_207361.1. NC_000915.1.
    YP_006934488.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O25290. 2 interactions.
    STRINGi 85962.HP0566.

    Proteomic databases

    PRIDEi O25290.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07622 ; AAD07622 ; HP_0566 .
    GeneIDi 13869756.
    899009.
    KEGGi heo:C694_02920.
    hpy:HP0566.
    PATRICi 20592405. VBIHelPyl33062_0591.

    Phylogenomic databases

    eggNOGi COG0253.
    KOi K01778.
    OMAi INTGSPH.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci HPY:HP0566-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDAPF_HELPY
    AccessioniPrimary (citable) accession number: O25290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3