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O25286

- O25286_HELPY

UniProt

O25286 - O25286_HELPY

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Protein
Submitted name: 3-ketoacyl-(Acyl-carrier-protein) reductase
Gene
fabG, C694_02895, HP_0561
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171NAD; via amide nitrogenImported
Binding sitei37 – 371NADImported
Binding sitei90 – 901NAD; via carbonyl oxygenImported
Binding sitei113 – 1131NADImported
Binding sitei155 – 1551NADImported
Binding sitei159 – 1591NADImported
Metal bindingi237 – 2371PotassiumImported
Metal bindingi238 – 2381Potassium; via carbonyl oxygenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 642NADImported
Nucleotide bindingi185 – 1906NADImported

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

Metal-bindingImported, NADImported, Nucleotide-bindingImported, PotassiumImported

Enzyme and pathway databases

BioCyciHPY:HP0561-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
3-ketoacyl-(Acyl-carrier-protein) reductaseImported (EC:1.1.1.100Imported)
Submitted name:
3-ketoacyl-acyl carrier protein reductase (FabG)Imported
Gene namesi
Name:fabGImported
Ordered Locus Names:C694_02895Imported, HP_0561Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome, UP000010112: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0561.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IINX-ray2.40A/B/C/D1-247[»]
4IJKX-ray2.54A/B/C/D1-247[»]

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00059.
OMAiEGTTANC.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25286-1 [UniParc]FASTAAdd to Basket

« Hide

MQFTGKNVLI TGASKGIGAE IAKTLASMGL KVWINYRSNA EVADALKNEL    50
EEKGYKAAVI KFDAASESDF IEAIQTIVQS DGGLSYLVNN AGVVRDKLAI 100
KMKTEDFHHV IDNNLTSAFI GCREALKVMS KSRFGSVVNV ASIIGERGNM 150
GQTNYSASKG GMIAMSKSFA YEGALRNIRF NSVTPGFIET DMNANLKDEL 200
KADYVKNIPL NRLGSAKEVA EAVAFLLSDH SSYITGETLK VNGGLYM 247
Length:247
Mass (Da):26,668
Last modified:January 1, 1998 - v1
Checksum:i3F76B625834EA1CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07627.1.
CP003904 Genomic DNA. Translation: AFV41780.1.
PIRiA64590.
RefSeqiNP_207356.1. NC_000915.1.
YP_006934483.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07627; AAD07627; HP_0561.
AFV41780; AFV41780; C694_02895.
GeneIDi13869751.
900034.
KEGGiheo:C694_02895.
hpy:HP0561.
PATRICi20592395. VBIHelPyl33062_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07627.1 .
CP003904 Genomic DNA. Translation: AFV41780.1 .
PIRi A64590.
RefSeqi NP_207356.1. NC_000915.1.
YP_006934483.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IIN X-ray 2.40 A/B/C/D 1-247 [» ]
4IJK X-ray 2.54 A/B/C/D 1-247 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07627 ; AAD07627 ; HP_0561 .
AFV41780 ; AFV41780 ; C694_02895 .
GeneIDi 13869751.
900034.
KEGGi heo:C694_02895.
hpy:HP0561.
PATRICi 20592395. VBIHelPyl33062_0586.

Phylogenomic databases

KOi K00059.
OMAi EGTTANC.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

BioCyci HPY:HP0561-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 26695Imported and ATCC 700392 / 26695.
  2. White O.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695.
  3. "Draft genome of Helicobacter pylori."
    Chelysheva V., Selezneva O., Alexeev D., Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Kostryukova E., Govorun V., Momynaliev K.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 26695Imported.
  4. "Draft genome of Helicobacter pylori."
    Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D., Kostrjukova E., Govorun V.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  5. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 complexed with NAD+."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH NAD AND POTASSIUM.
  6. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I.G., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS).

Entry informationi

Entry nameiO25286_HELPY
AccessioniPrimary (citable) accession number: O25286
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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