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Protein
Submitted name:

3-ketoacyl-acyl carrier protein reductase (FabG)

Gene

HP_0561

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171NAD; via amide nitrogenCombined sources
Binding sitei37 – 371NADCombined sources
Binding sitei90 – 901NAD; via carbonyl oxygenCombined sources
Binding sitei113 – 1131NADCombined sources
Binding sitei155 – 1551NADCombined sources
Binding sitei159 – 1591NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 642NADCombined sources
Nucleotide bindingi185 – 1906NADCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciHPY:HP0561-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
3-ketoacyl-acyl carrier protein reductase (FabG)Imported
Gene namesi
Ordered Locus Names:HP_0561Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0561.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IINX-ray2.40A/B/C/D1-247[»]
4IJKX-ray2.54A/B/C/D1-247[»]
ProteinModelPortaliO25286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK00059.
OMAiSAFIGCK.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFTGKNVLI TGASKGIGAE IAKTLASMGL KVWINYRSNA EVADALKNEL
60 70 80 90 100
EEKGYKAAVI KFDAASESDF IEAIQTIVQS DGGLSYLVNN AGVVRDKLAI
110 120 130 140 150
KMKTEDFHHV IDNNLTSAFI GCREALKVMS KSRFGSVVNV ASIIGERGNM
160 170 180 190 200
GQTNYSASKG GMIAMSKSFA YEGALRNIRF NSVTPGFIET DMNANLKDEL
210 220 230 240
KADYVKNIPL NRLGSAKEVA EAVAFLLSDH SSYITGETLK VNGGLYM
Length:247
Mass (Da):26,668
Last modified:January 1, 1998 - v1
Checksum:i3F76B625834EA1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07627.1.
PIRiA64590.
RefSeqiNP_207356.1. NC_000915.1.
WP_001160833.1. NC_018939.1.
YP_006934483.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07627; AAD07627; HP_0561.
AFV41780; AFV41780; C694_02895.
GeneIDi900034.
KEGGiheo:C694_02895.
hpy:HP0561.
PATRICi20592395. VBIHelPyl33062_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07627.1.
PIRiA64590.
RefSeqiNP_207356.1. NC_000915.1.
WP_001160833.1. NC_018939.1.
YP_006934483.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IINX-ray2.40A/B/C/D1-247[»]
4IJKX-ray2.54A/B/C/D1-247[»]
ProteinModelPortaliO25286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07627; AAD07627; HP_0561.
AFV41780; AFV41780; C694_02895.
GeneIDi900034.
KEGGiheo:C694_02895.
hpy:HP0561.
PATRICi20592395. VBIHelPyl33062_0586.

Phylogenomic databases

KOiK00059.
OMAiSAFIGCK.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciHPY:HP0561-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695Imported.
  2. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 complexed with NAD+."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH NAD.
  3. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I.G., Shatsman S., Anderson W.F., Minor W.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS).

Entry informationi

Entry nameiO25286_HELPY
AccessioniPrimary (citable) accession number: O25286
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.