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O25286

- O25286_HELPY

UniProt

O25286 - O25286_HELPY

Protein
Submitted name:

3-ketoacyl-(Acyl-carrier-protein) reductase

Gene

fabG

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171NAD; via amide nitrogenImported
    Binding sitei37 – 371NADImported
    Binding sitei90 – 901NAD; via carbonyl oxygenImported
    Binding sitei113 – 1131NADImported
    Binding sitei155 – 1551NADImported
    Binding sitei159 – 1591NADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 642NADImported
    Nucleotide bindingi185 – 1906NADImported

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    NADImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciHPY:HP0561-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-ketoacyl-(Acyl-carrier-protein) reductaseImported (EC:1.1.1.100Imported)
    Submitted name:
    3-ketoacyl-acyl carrier protein reductase (FabG)Imported
    Gene namesi
    Name:fabGImported
    Ordered Locus Names:C694_02895Imported, HP_0561Imported
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome, UP000010112: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0561.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IINX-ray2.40A/B/C/D1-247[»]
    4IJKX-ray2.54A/B/C/D1-247[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Phylogenomic databases

    KOiK00059.
    OMAiEGTTANC.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25286-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFTGKNVLI TGASKGIGAE IAKTLASMGL KVWINYRSNA EVADALKNEL    50
    EEKGYKAAVI KFDAASESDF IEAIQTIVQS DGGLSYLVNN AGVVRDKLAI 100
    KMKTEDFHHV IDNNLTSAFI GCREALKVMS KSRFGSVVNV ASIIGERGNM 150
    GQTNYSASKG GMIAMSKSFA YEGALRNIRF NSVTPGFIET DMNANLKDEL 200
    KADYVKNIPL NRLGSAKEVA EAVAFLLSDH SSYITGETLK VNGGLYM 247
    Length:247
    Mass (Da):26,668
    Last modified:January 1, 1998 - v1
    Checksum:i3F76B625834EA1CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07627.1.
    CP003904 Genomic DNA. Translation: AFV41780.1.
    PIRiA64590.
    RefSeqiNP_207356.1. NC_000915.1.
    YP_006934483.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07627; AAD07627; HP_0561.
    AFV41780; AFV41780; C694_02895.
    GeneIDi13869751.
    900034.
    KEGGiheo:C694_02895.
    hpy:HP0561.
    PATRICi20592395. VBIHelPyl33062_0586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07627.1 .
    CP003904 Genomic DNA. Translation: AFV41780.1 .
    PIRi A64590.
    RefSeqi NP_207356.1. NC_000915.1.
    YP_006934483.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IIN X-ray 2.40 A/B/C/D 1-247 [» ]
    4IJK X-ray 2.54 A/B/C/D 1-247 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07627 ; AAD07627 ; HP_0561 .
    AFV41780 ; AFV41780 ; C694_02895 .
    GeneIDi 13869751.
    900034.
    KEGGi heo:C694_02895.
    hpy:HP0561.
    PATRICi 20592395. VBIHelPyl33062_0586.

    Phylogenomic databases

    KOi K00059.
    OMAi EGTTANC.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    BioCyci HPY:HP0561-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 26695Imported and ATCC 700392 / 26695Imported.
    2. White O.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 26695.
    3. "Draft genome of Helicobacter pylori."
      Chelysheva V., Selezneva O., Alexeev D., Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Kostryukova E., Govorun V., Momynaliev K.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 26695Imported.
    4. "Draft genome of Helicobacter pylori."
      Manolov A., Prihodko E., Larin A., Karpova I., Semashko T., Alexeev D., Kostrjukova E., Govorun V.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695Imported.
    5. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 complexed with NAD+."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I., Shatsman S., Anderson W.F., Minor W.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH NAD.
    6. "Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Hou J., Osinski T., Zheng H., Shumilin I., Shabalin I.G., Shatsman S., Anderson W.F., Minor W.
      Submitted (DEC-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS).

    Entry informationi

    Entry nameiO25286_HELPY
    AccessioniPrimary (citable) accession number: O25286
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3