O25284 (O25284_HELPY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 PIRNR PIRNR000447
EC=2.3.1.179 PIRNR PIRNR000447

Gene names

Ordered Locus Names:

HP_0558

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity. PIRNR PIRNR000447
Catalytic activity	(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. PIRNR PIRNR000447
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000447
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family. PIRNR PIRNR000447 RuleBase RU003694

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000447 Lipid synthesis
Molecular function	Transferase PIRNR PIRNR000447 RuleBase RU003694
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	beta-ketoacyl-acyl-carrier-protein synthase II activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O25284 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: AE5E041F1D0B9B0E	FASTA	412	43,564
	10 20 30 40 50 60 MRRIVVTGMG MINSLGLNKE DSFLAIAKGE CGIKHIESFD ASAFPVRIAG EITDFDPTEV 70 80 90 100 110 120 MNPKDVKKAG RFIQLALKAT REAMKDSGIL DAHNRCPEEL ANRMGVSSGS GIGGLGNIEA 130 140 150 160 170 180 NSIFCFEKGP RKVNPFFITS ALVNMIGGFT SIEFGIKGPN LSSVTACAAG THAIIEAVKT 190 200 210 220 230 240 ILLNGADKML VVGAESTICP VGIGGFASIK ALSTRNDDPK KASRPFDKDR NGFVMGEGAG 250 260 270 280 290 300 ALVLEEYESA KRRGAKIYAE FAGYGESGDA NHITAPAPEG EGAFRAMKMA LEMAKVEIGY 310 320 330 340 350 360 VNAHGTSTHY NDLYESIALK NVFGSKEKVP PVSSTKGQIG HCLGAAGALE AVISIMAMNQ 370 380 390 400 410 GILPPTINQE MPDPECDLDY IPNAAREKRV DAVMSNSFGF GGTNGVVIFK KA

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07625.1.
PIR	F64589.
RefSeq	NP_207353.1. NC_000915.1.
3D structure databases
HSSP	HSSP built from PDB template 1KAS based on UniProtKB P39435.
ProteinModelPortal	O25284.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3484N.
MINT	MINT-161588.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	898935.
GenomeReviews	Gene locus HP_0558 in contig AE000511_GR.
KEGG	hpy:HP0558.
NMPDR	fig|85962.1.peg.551.
PATRIC	20592391. VBIHelPyl33062_0584.
TIGR	HP_0558.
Phylogenomic databases
HOGENOM	HBG757733.
OMA	NRCPEEL.
ProtClustDB	PRK08439.
Family and domain databases
InterPro	IPR017568. 3-oxoacyl-ACP_synth-2. IPR000794. Beta-ketoacyl_synthase. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KO	K09458.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
PIRSF	PIRSF000447. KAS_II. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR03150. FabF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

O25284_HELPY

Accession

Primary (citable) accession number: O25284

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)