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O25242

- DPO3B_HELPY

UniProt

O25242 - DPO3B_HELPY

Protein

DNA polymerase III subunit beta

Gene

dnaN

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. DNA binding Source: InterPro
    3. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    4. protein binding Source: IntAct

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    BioCyciHPY:HP0500-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit beta (EC:2.7.7.7)
    Gene namesi
    Name:dnaN
    Ordered Locus Names:HP_0500
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. DNA polymerase III complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374DNA polymerase III subunit betaPRO_0000105438Add
    BLAST

    Proteomic databases

    PRIDEiO25242.

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HP_0418O251723EBI-7532786,EBI-9262675

    Protein-protein interaction databases

    DIPiDIP-3288N.
    IntActiO25242. 2 interactions.
    MINTiMINT-176339.
    STRINGi85962.HP0500.

    Structurei

    3D structure databases

    ProteinModelPortaliO25242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0592.
    KOiK02338.
    OMAiPENDFPD.
    OrthoDBiEOG65J53F.

    Family and domain databases

    InterProiIPR001001. DNA_polIII_beta.
    IPR022635. DNA_polIII_beta_C.
    IPR022637. DNA_polIII_beta_cen.
    IPR022634. DNA_polIII_beta_N.
    [Graphical view]
    PfamiPF00712. DNA_pol3_beta. 1 hit.
    PF02767. DNA_pol3_beta_2. 1 hit.
    PF02768. DNA_pol3_beta_3. 1 hit.
    [Graphical view]
    SMARTiSM00480. POL3Bc. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00663. dnan. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O25242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISVSKNDL ENALRYLQAF LDKKDASSIA SHIHLEVIKE KLFLKASDSD    50
    IGLKSYIFTQ SSDKEGVGTI NGKKFLDIIS CLKDSNIILE TKDDSLAIKQ 100
    NKSSFKLPMF DADEFPEFPV IDPKVSIEVN APFLVDAFKK IAPVIEQTSH 150
    KRELAGILMQ FDQKHQTLSV VGTDTKRLSY TQLEKISIHS TEEDISCILP 200
    KRALLEILKL FYENFSFKSD GMLAVIENEM HTFFTKLIDG NYPDYQKILP 250
    KEYISSFTLG KEEFKESIKL CSSLSSTIKL TLEKNNALFE SLDSEHSETA 300
    KTSVEIEKGL DIEKAFHLGV NAKFFLEALN ALGTTQFVLR CNEPSSPFLI 350
    QESLDEKQSH LNAKISTLMM PITL 374
    Length:374
    Mass (Da):42,185
    Last modified:January 1, 1998 - v1
    Checksum:i5C1FE1C6290FDE6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07565.1.
    PIRiD64582.
    RefSeqiNP_207297.1. NC_000915.1.
    YP_006934422.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07565; AAD07565; HP_0500.
    GeneIDi13869690.
    899259.
    KEGGiheo:C694_02570.
    hpy:HP0500.
    PATRICi20592275. VBIHelPyl33062_0526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07565.1 .
    PIRi D64582.
    RefSeqi NP_207297.1. NC_000915.1.
    YP_006934422.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3288N.
    IntActi O25242. 2 interactions.
    MINTi MINT-176339.
    STRINGi 85962.HP0500.

    Proteomic databases

    PRIDEi O25242.

    Protocols and materials databases

    DNASUi 899259.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07565 ; AAD07565 ; HP_0500 .
    GeneIDi 13869690.
    899259.
    KEGGi heo:C694_02570.
    hpy:HP0500.
    PATRICi 20592275. VBIHelPyl33062_0526.

    Phylogenomic databases

    eggNOGi COG0592.
    KOi K02338.
    OMAi PENDFPD.
    OrthoDBi EOG65J53F.

    Enzyme and pathway databases

    BioCyci HPY:HP0500-MONOMER.

    Family and domain databases

    InterProi IPR001001. DNA_polIII_beta.
    IPR022635. DNA_polIII_beta_C.
    IPR022637. DNA_polIII_beta_cen.
    IPR022634. DNA_polIII_beta_N.
    [Graphical view ]
    Pfami PF00712. DNA_pol3_beta. 1 hit.
    PF02767. DNA_pol3_beta_2. 1 hit.
    PF02768. DNA_pol3_beta_3. 1 hit.
    [Graphical view ]
    SMARTi SM00480. POL3Bc. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00663. dnan. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDPO3B_HELPY
    AccessioniPrimary (citable) accession number: O25242
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names

    External Data

    Dasty 3