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O25242 (DPO3B_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit beta

EC=2.7.7.7
Gene names
Name:dnaN
Ordered Locus Names:HP_0500
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Subcellular location

Cytoplasm By similarity.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HP_0418O251723EBI-7532786,EBI-9262675

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374DNA polymerase III subunit beta
PRO_0000105438

Sequences

Sequence LengthMass (Da)Tools
O25242 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5C1FE1C6290FDE6C

FASTA37442,185
        10         20         30         40         50         60 
MKISVSKNDL ENALRYLQAF LDKKDASSIA SHIHLEVIKE KLFLKASDSD IGLKSYIFTQ 

        70         80         90        100        110        120 
SSDKEGVGTI NGKKFLDIIS CLKDSNIILE TKDDSLAIKQ NKSSFKLPMF DADEFPEFPV 

       130        140        150        160        170        180 
IDPKVSIEVN APFLVDAFKK IAPVIEQTSH KRELAGILMQ FDQKHQTLSV VGTDTKRLSY 

       190        200        210        220        230        240 
TQLEKISIHS TEEDISCILP KRALLEILKL FYENFSFKSD GMLAVIENEM HTFFTKLIDG 

       250        260        270        280        290        300 
NYPDYQKILP KEYISSFTLG KEEFKESIKL CSSLSSTIKL TLEKNNALFE SLDSEHSETA 

       310        320        330        340        350        360 
KTSVEIEKGL DIEKAFHLGV NAKFFLEALN ALGTTQFVLR CNEPSSPFLI QESLDEKQSH 

       370 
LNAKISTLMM PITL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07565.1.
PIRD64582.
RefSeqNP_207297.1. NC_000915.1.
YP_006934422.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3288N.
IntActO25242. 2 interactions.
MINTMINT-176339.
STRING85962.HP0500.

Proteomic databases

PRIDEO25242.

Protocols and materials databases

DNASU899259.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07565; AAD07565; HP_0500.
GeneID899259.
KEGGheo:C694_02570.
hpy:HP0500.
PATRIC20592275. VBIHelPyl33062_0526.

Phylogenomic databases

eggNOGCOG0592.
KOK02338.
OMAPENDFPD.
OrthoDBEOG65J53F.

Enzyme and pathway databases

BioCycHPY:HP0500-MONOMER.

Family and domain databases

InterProIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
SMARTSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00663. dnan. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPO3B_HELPY
AccessionPrimary (citable) accession number: O25242
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names