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Protein

GTP-binding protein TypA/BipA homolog

Gene

typA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Not known; probably interacts with the ribosomes in a GTP dependent manner.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTPBy similarity
Nucleotide bindingi73 – 775GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein TypA/BipA homolog
Gene namesi
Name:typA
Ordered Locus Names:HP_0480
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599GTP-binding protein TypA/BipA homologPRO_0000091555Add
BLAST

Proteomic databases

PRIDEiO25225.

Interactioni

Protein-protein interaction databases

IntActiO25225. 5 interactions.
MINTiMINT-4074340.
STRINGi85962.HP0480.

Structurei

3D structure databases

ProteinModelPortaliO25225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 197196tr-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. TypA subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1217.
KOiK06207.
OMAiDGKVHEP.
OrthoDBiEOG67HJSM.

Family and domain databases

Gene3Di3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR006298. TypA_GTP-bd.
[Graphical view]
PANTHERiPTHR23115:SF14. PTHR23115:SF14. 1 hit.
PfamiPF00679. EFG_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
TIGR01394. TypA_BipA. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIRNIAVI AHVDHGKTTL VDGLLSQSGT FSEREKVDER VMDSNDLERE
60 70 80 90 100
RGITILSKNT AIYYKDTKIN IIDTPGHADF GGEVERVLKM VDGVLLLVDA
110 120 130 140 150
QEGVMPQTKF VVKKALSFGI CPIVVVNKID KPAAEPDRVV DEVFDLFVAM
160 170 180 190 200
GASDKQLDFP VVYAAARDGY AMKSLDDEKK NLEPLFETIL EHVPSPSGSV
210 220 230 240 250
DEPLQMQIFT LDYDNYVGKI GIARVFNGSV KKNESVLLMK SDGSKENGRI
260 270 280 290 300
TKLIGFLGLA RTEIENAYAG DIVAIAGFNA MDVGDSVVDP ANPMPLDPMH
310 320 330 340 350
LEEPTMSVYF AVNDSPLAGL EGKHVTANKL KDRLLKEMQT NIAMKCEEMG
360 370 380 390 400
EGKFKVSGRG ELQITILAEN LRREGFEFSI SRPEVIIKEE NGVKCEPFEH
410 420 430 440 450
LVIDTPQDFS GAIIERLGKR KAEMKAMNPM SDGYTRLEFE IPARGLIGYR
460 470 480 490 500
SEFLTDTKGE GVMNHSFLEF RPFSGSVESR KNGALISMEN GEATAFSLFN
510 520 530 540 550
IQERGTLFIN PQTKVYVGMV IGEHSRDNDL DVNPIKSKHL TNMRASGSDD
560 570 580 590
AIKLTPPRTM VLERALEWIE EDEILEVTPL NLRIRKKILD PNMRKRAKK
Length:599
Mass (Da):66,676
Last modified:January 1, 1998 - v1
Checksum:i93E785506BCAEEA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07546.1.
PIRiH64579.
RefSeqiNP_207278.1. NC_000915.1.
YP_006934400.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07546; AAD07546; HP_0480.
GeneIDi898837.
KEGGiheo:C694_02460.
hpy:HP0480.
PATRICi20592231. VBIHelPyl33062_0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07546.1.
PIRiH64579.
RefSeqiNP_207278.1. NC_000915.1.
YP_006934400.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25225. 5 interactions.
MINTiMINT-4074340.
STRINGi85962.HP0480.

Proteomic databases

PRIDEiO25225.

Protocols and materials databases

DNASUi898837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07546; AAD07546; HP_0480.
GeneIDi898837.
KEGGiheo:C694_02460.
hpy:HP0480.
PATRICi20592231. VBIHelPyl33062_0504.

Phylogenomic databases

eggNOGiCOG1217.
KOiK06207.
OMAiDGKVHEP.
OrthoDBiEOG67HJSM.

Enzyme and pathway databases

BioCyciHPY:HP0480-MONOMER.

Family and domain databases

Gene3Di3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR006298. TypA_GTP-bd.
[Graphical view]
PANTHERiPTHR23115:SF14. PTHR23115:SF14. 1 hit.
PfamiPF00679. EFG_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
TIGR01394. TypA_BipA. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTYPA_HELPY
AccessioniPrimary (citable) accession number: O25225
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.