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Protein

Arginine decarboxylase

Gene

HP_0422

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseSAAS annotation, Lyase

Keywords - Biological processi

Spermidine biosynthesisSAAS annotation

Keywords - Ligandi

MagnesiumSAAS annotation, Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPY:HP0422-MONOMER.
BRENDAi4.1.1.19. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylaseSAAS annotation (EC:4.1.1.19SAAS annotation)
Gene namesi
Ordered Locus Names:HP_0422Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiO25176.

Interactioni

Protein-protein interaction databases

DIPiDIP-3228N.
IntActiO25176. 5 interactions.
MINTiMINT-161428.
STRINGi85962.HP0422.

Structurei

3D structure databases

ProteinModelPortaliO25176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 332255Orn_Arg_deC_NInterPro annotationAdd
BLAST
Domaini437 – 539103Orn_DAP_Arg_deCInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5. Bacteria.
COG1166. LUCA.
KOiK01585.
OMAiDQLFPIM.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 2 hits.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.

Sequencei

Sequence statusi: Complete.

O25176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVHDYGIK FWSNNEFKIE KGLVKVCHGK NPSLLEIVQS VRDKGYRGPL
60 70 80 90 100
LVRFPHLVQK QIKSLFDAFS SAIKEYQYSG AFKAVFPLKV NQMPSFVFPL
110 120 130 140 150
VQGAKGLNYG LEAGSKSELI IAMSYTNPKA PITVNGFKDK EMIELGFIAK
160 170 180 190 200
SMQHEITLTI EGLNELKTII AVAKQNEFLA CPKIGIRIRL HSTGTGVWAK
210 220 230 240 250
SGGINSKFGL SSTEVLEAMR LLEENDLLEH FHMIHFHIGS QISDISPLKK
260 270 280 290 300
ALREAGNLYA ELRKMGAKNL NSVNIGGGLA VEYTQHKHHQ DKNYTLEEFS
310 320 330 340 350
ADVVFLLREI VKNKQEIEPD IFIESGRYIS ANHAVLVAPV LELFSHEYNE
360 370 380 390 400
KSLKIKENNN PPLIDEMLDL LANINEKNAI EYLHDSFDHT ESLFTLFDLG
410 420 430 440 450
YIDLIDRSNT EVLAHLIVKK AVQLLYVKDH NDILRIQEQV QERYLLNCSF
460 470 480 490 500
FQSLPDYWGL RQNFPVMPLN KLDEKPTRSA SLWDITCDSD GEIAFDSTKP
510 520 530 540 550
LFLHDIDIDE EEYFLAFFLV GAYQEVLGMK HNLFTHPTEF SVVFDEKGDY
560 570 580 590 600
EVEDICEAQT ILDVLDDLDY DTKEIERLLK QKIEDNNQLD MEEKKEIMGR
610
LYVMLSENGY LRTIS
Length:615
Mass (Da):70,329
Last modified:January 1, 1998 - v1
Checksum:i7230B0A34822408A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07486.1.
PIRiF64572.
RefSeqiNP_207220.1. NC_000915.1.
WP_001158562.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07486; AAD07486; HP_0422.
GeneIDi898896.
KEGGiheo:C694_02150.
hpy:HP0422.
PATRICi20592095. VBIHelPyl33062_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07486.1.
PIRiF64572.
RefSeqiNP_207220.1. NC_000915.1.
WP_001158562.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3228N.
IntActiO25176. 5 interactions.
MINTiMINT-161428.
STRINGi85962.HP0422.

Proteomic databases

PaxDbiO25176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07486; AAD07486; HP_0422.
GeneIDi898896.
KEGGiheo:C694_02150.
hpy:HP0422.
PATRICi20592095. VBIHelPyl33062_0437.

Phylogenomic databases

eggNOGiENOG4105DP5. Bacteria.
COG1166. LUCA.
KOiK01585.
OMAiDQLFPIM.

Enzyme and pathway databases

BioCyciHPY:HP0422-MONOMER.
BRENDAi4.1.1.19. 2604.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 2 hits.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO25176_HELPY
AccessioniPrimary (citable) accession number: O25176
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.