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Protein

dCTP deaminase

Gene

dcd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:HP_0372
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559901 – 188dCTP deaminaseAdd BLAST188

Proteomic databases

PaxDbiO25136.
PRIDEiO25136.

Interactioni

Protein-protein interaction databases

IntActiO25136. 1 interactor.
MINTiMINT-169872.
STRINGi85962.HP0372.

Structurei

3D structure databases

ProteinModelPortaliO25136.
SMRiO25136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
KOiK01494.
OMAiGQLCLFR.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

O25136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKADSWIK KMSLEHGMIS PFCEKQVGKN VISYGLSSYG YDIRVGSEFM
60 70 80 90 100
LFDNKNALID PKNFDPNNAT KIDASKEGYF ILPANAFALA HTIEYFKMPK
110 120 130 140 150
DTLAICLGKS TYARCGIIVN VTPFEPEFEG YITIEISNTT NLPAKVYANE
160 170 180
GIAQVVFLQG DEMCEQSYKD RGGKYQGQVG ITLPKILK
Length:188
Mass (Da):20,904
Last modified:December 1, 2000 - v2
Checksum:iF45AEE3C3F040876
GO

Sequence cautioni

The sequence AAD07441 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07441.1. Different initiation.
PIRiD64566.
RefSeqiNP_207170.1. NC_000915.1.
WP_000523106.1. NC_018939.1.
WP_010875474.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07441; AAD07441; HP_0372.
GeneIDi898857.
KEGGiheo:C694_01890.
hpy:HP0372.
PATRICifig|85962.47.peg.395.

Similar proteinsi

Entry informationi

Entry nameiDCD_HELPY
AccessioniPrimary (citable) accession number: O25136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families