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O25121

- DXS_HELPY

UniProt

O25121 - DXS_HELPY

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Protein
1-deoxy-D-xylulose-5-phosphate synthase
Gene
dxs, HP_0354
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701Thiamine pyrophosphate By similarity
Metal bindingi142 – 1421Magnesium By similarity
Metal bindingi171 – 1711Magnesium By similarity
Binding sitei171 – 1711Thiamine pyrophosphate By similarity
Binding sitei278 – 2781Thiamine pyrophosphate By similarity
Binding sitei360 – 3601Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Thiamine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciHPY:HP0354-MONOMER.
UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase (EC:2.2.1.7)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name:
DXP synthase
Short name:
DXPS
Gene namesi
Name:dxs
Ordered Locus Names:HP_0354
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6186181-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation
PRO_0000189119Add
BLAST

Proteomic databases

PRIDEiO25121.

PTM databases

PhosSiteiP11041029.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3091N.
IntActiO25121. 5 interactions.
MINTiMINT-163092.
STRINGi85962.HP0354.

Structurei

3D structure databases

ProteinModelPortaliO25121.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1133Thiamine pyrophosphate binding By similarity
Regioni143 – 1442Thiamine pyrophosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1154.
KOiK01662.
OMAiAATCETF.
OrthoDBiEOG6BKJ6P.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25121-1 [UniParc]FASTAAdd to Basket

« Hide

MILQNKTFDL NPNDIAGLEL VCQTLRNRIL EVVSANGGHL SSSLGAVELI    50
VGMHALFDCQ KNPFIFDTSH QAYAHKLLTG RFESFSTLRQ FKGLSGFTKP 100
SESAYDYFIA GHSSTSVSIG VGVAKAFCLK QALGMPIALL GDGSISAGIF 150
YEALNELGDR KYPMIMILND NEMSISTPIG ALSKALSQLM KGPFYQSFRS 200
KVKKILSTLP ESVNYLASRF EESFKLITPG VFFEELGINY IGPINGHDLS 250
AIIETLKLAK ELKEPVLIHA QTLKGKGYKI AEGRYEKWHG VGPFDLDTGL 300
SKKSKSAILS PTEAYSNTLL ELAKKDEKIV GVTAAMPSGT GLDKLIDAYP 350
LRFFDVAIAE QHALTSSSAM AKEGFKPFVS IYSTFLQRAY DSIVHDACIS 400
SLPIKLAIDR AGIVGEDGET HQGLLDVSYL RSIPNMVIFA PRDNETLKNA 450
VRFANEHDSS PCAFRYPRGS FALKEGVFEP SGFVLGQSEL LKKEGEILLI 500
GYGNGVGRAH LVQLALKEKN IECALLDLRF LKPLDPNLSA IVAPYQKLYV 550
FSDNYKLGGV ASAILEFLSE QNILKPVKSF EIIDEFIMHG NTALVEKSLG 600
LDTESLTDAI LKDLGQER 618
Length:618
Mass (Da):67,634
Last modified:January 1, 1998 - v1
Checksum:i87334832DAFE3383
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07422.1.
PIRiB64564.
RefSeqiNP_207152.1. NC_000915.1.
WP_000602987.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07422; AAD07422; HP_0354.
GeneIDi898853.
KEGGihpy:HP0354.
PATRICi20591941. VBIHelPyl33062_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07422.1 .
PIRi B64564.
RefSeqi NP_207152.1. NC_000915.1.
WP_000602987.1. NC_000915.1.

3D structure databases

ProteinModelPortali O25121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3091N.
IntActi O25121. 5 interactions.
MINTi MINT-163092.
STRINGi 85962.HP0354.

PTM databases

PhosSitei P11041029.

Proteomic databases

PRIDEi O25121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07422 ; AAD07422 ; HP_0354 .
GeneIDi 898853.
KEGGi hpy:HP0354.
PATRICi 20591941. VBIHelPyl33062_0367.

Phylogenomic databases

eggNOGi COG1154.
KOi K01662.
OMAi AATCETF.
OrthoDBi EOG6BKJ6P.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .
BioCyci HPY:HP0354-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDXS_HELPY
AccessioniPrimary (citable) accession number: O25121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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