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O25121

- DXS_HELPY

UniProt

O25121 - DXS_HELPY

Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701Thiamine pyrophosphateUniRule annotation
    Metal bindingi142 – 1421MagnesiumUniRule annotation
    Metal bindingi171 – 1711MagnesiumUniRule annotation
    Binding sitei171 – 1711Thiamine pyrophosphateUniRule annotation
    Binding sitei278 – 2781Thiamine pyrophosphateUniRule annotation
    Binding sitei360 – 3601Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Thiamine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciHPY:HP0354-MONOMER.
    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthaseUniRule annotation
    Short name:
    DXP synthaseUniRule annotation
    Short name:
    DXPSUniRule annotation
    Gene namesi
    Name:dxsUniRule annotation
    Ordered Locus Names:HP_0354
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6186181-deoxy-D-xylulose-5-phosphate synthasePRO_0000189119Add
    BLAST

    Proteomic databases

    PRIDEiO25121.

    PTM databases

    PhosSiteiP11041029.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3091N.
    IntActiO25121. 5 interactions.
    MINTiMINT-163092.
    STRINGi85962.HP0354.

    Structurei

    3D structure databases

    ProteinModelPortaliO25121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 1133Thiamine pyrophosphate bindingUniRule annotation
    Regioni143 – 1442Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    KOiK01662.
    OMAiAATCETF.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25121-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILQNKTFDL NPNDIAGLEL VCQTLRNRIL EVVSANGGHL SSSLGAVELI    50
    VGMHALFDCQ KNPFIFDTSH QAYAHKLLTG RFESFSTLRQ FKGLSGFTKP 100
    SESAYDYFIA GHSSTSVSIG VGVAKAFCLK QALGMPIALL GDGSISAGIF 150
    YEALNELGDR KYPMIMILND NEMSISTPIG ALSKALSQLM KGPFYQSFRS 200
    KVKKILSTLP ESVNYLASRF EESFKLITPG VFFEELGINY IGPINGHDLS 250
    AIIETLKLAK ELKEPVLIHA QTLKGKGYKI AEGRYEKWHG VGPFDLDTGL 300
    SKKSKSAILS PTEAYSNTLL ELAKKDEKIV GVTAAMPSGT GLDKLIDAYP 350
    LRFFDVAIAE QHALTSSSAM AKEGFKPFVS IYSTFLQRAY DSIVHDACIS 400
    SLPIKLAIDR AGIVGEDGET HQGLLDVSYL RSIPNMVIFA PRDNETLKNA 450
    VRFANEHDSS PCAFRYPRGS FALKEGVFEP SGFVLGQSEL LKKEGEILLI 500
    GYGNGVGRAH LVQLALKEKN IECALLDLRF LKPLDPNLSA IVAPYQKLYV 550
    FSDNYKLGGV ASAILEFLSE QNILKPVKSF EIIDEFIMHG NTALVEKSLG 600
    LDTESLTDAI LKDLGQER 618
    Length:618
    Mass (Da):67,634
    Last modified:January 1, 1998 - v1
    Checksum:i87334832DAFE3383
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07422.1.
    PIRiB64564.
    RefSeqiNP_207152.1. NC_000915.1.
    WP_000602987.1. NC_000915.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07422; AAD07422; HP_0354.
    GeneIDi898853.
    KEGGihpy:HP0354.
    PATRICi20591941. VBIHelPyl33062_0367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07422.1 .
    PIRi B64564.
    RefSeqi NP_207152.1. NC_000915.1.
    WP_000602987.1. NC_000915.1.

    3D structure databases

    ProteinModelPortali O25121.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3091N.
    IntActi O25121. 5 interactions.
    MINTi MINT-163092.
    STRINGi 85962.HP0354.

    PTM databases

    PhosSitei P11041029.

    Proteomic databases

    PRIDEi O25121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07422 ; AAD07422 ; HP_0354 .
    GeneIDi 898853.
    KEGGi hpy:HP0354.
    PATRICi 20591941. VBIHelPyl33062_0367.

    Phylogenomic databases

    eggNOGi COG1154.
    KOi K01662.
    OMAi AATCETF.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .
    BioCyci HPY:HP0354-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDXS_HELPY
    AccessioniPrimary (citable) accession number: O25121
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3