Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O25103

- HCPB_HELPY

UniProt

O25103 - HCPB_HELPY

Protein

Beta-lactamase HcpB

Gene

hcpB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.1 Publication

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: CACAO

    GO - Biological processi

    1. metabolic process Source: GOC
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPY:HP0336-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase HcpB (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein B
    Gene namesi
    Name:hcpB
    Ordered Locus Names:HP_0336
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Beta-lactamase HcpBPRO_0000221379Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi22 ↔ 30
    Disulfide bondi52 ↔ 60
    Disulfide bondi88 ↔ 96
    Disulfide bondi124 ↔ 132

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO25103.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3342N.
    IntActiO25103. 50 interactions.
    MINTiMINT-160080.
    STRINGi85962.HP0336.

    Structurei

    Secondary structure

    1
    138
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 2317
    Helixi29 – 346
    Helixi41 – 5313
    Helixi57 – 6913
    Beta strandi71 – 733
    Helixi77 – 8913
    Helixi93 – 10513
    Beta strandi107 – 1093
    Helixi113 – 12513
    Helixi129 – 1346

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KLXX-ray1.95A1-138[»]
    ProteinModelPortaliO25103.
    SMRiO25103. Positions 3-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO25103.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 2828TPR 1Add
    BLAST
    Repeati57 – 9438TPR 2Add
    BLAST
    Repeati97 – 13034TPR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 3 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    OMAiSIACEAN.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF08238. Sel1. 4 hits.
    [Graphical view]
    SMARTiSM00671. SEL1. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25103-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGGGTVKKD LKKAIQYYVK ACELNEMFGC LSLVSNSQIN KQKLFQYLSK    50
    ACELNSGNGC RFLGDFYENG KYVKKDLRKA AQYYSKACGL NDQDGCLILG 100
    YKQYAGKGVV KNEKQAVKTF EKACRLGSED ACGILNNY 138
    Length:138
    Mass (Da):15,346
    Last modified:January 1, 1998 - v1
    Checksum:i4149505C1BE623B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07408.1.
    PIRiH64561.

    Genome annotation databases

    EnsemblBacteriaiAAD07408; AAD07408; HP_0336.
    PATRICi20591907. VBIHelPyl33062_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07408.1 .
    PIRi H64561.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KLX X-ray 1.95 A 1-138 [» ]
    ProteinModelPortali O25103.
    SMRi O25103. Positions 3-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3342N.
    IntActi O25103. 50 interactions.
    MINTi MINT-160080.
    STRINGi 85962.HP0336.

    Proteomic databases

    PRIDEi O25103.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07408 ; AAD07408 ; HP_0336 .
    PATRICi 20591907. VBIHelPyl33062_0350.

    Phylogenomic databases

    eggNOGi COG0790.
    OMAi SIACEAN.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPY:HP0336-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O25103.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF08238. Sel1. 4 hits.
    [Graphical view ]
    SMARTi SM00671. SEL1. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
      Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
      Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ANTIGENICITY.
    3. "The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein."
      Luethy L., Gruetter M.G., Mittl P.R.E.
      J. Biol. Chem. 277:10187-10193(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS), FUNCTION.

    Entry informationi

    Entry nameiHCPB_HELPY
    AccessioniPrimary (citable) accession number: O25103
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Antibodies against HcpB are present in sera from human patients infected by Helicobacter pylori.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3