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O25103

- HCPB_HELPY

UniProt

O25103 - HCPB_HELPY

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Protein

Beta-lactamase HcpB

Gene

hcpB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.1 Publication

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: CACAO

GO - Biological processi

  1. metabolic process Source: GOC
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP0336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase HcpB (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein B
Gene namesi
Name:hcpB
Ordered Locus Names:HP_0336
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Beta-lactamase HcpBPRO_0000221379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 30
Disulfide bondi52 ↔ 60
Disulfide bondi88 ↔ 96
Disulfide bondi124 ↔ 132

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO25103.

Interactioni

Protein-protein interaction databases

DIPiDIP-3342N.
IntActiO25103. 50 interactions.
MINTiMINT-160080.
STRINGi85962.HP0336.

Structurei

Secondary structure

1
138
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 2317Combined sources
Helixi29 – 346Combined sources
Helixi41 – 5313Combined sources
Helixi57 – 6913Combined sources
Beta strandi71 – 733Combined sources
Helixi77 – 8913Combined sources
Helixi93 – 10513Combined sources
Beta strandi107 – 1093Combined sources
Helixi113 – 12513Combined sources
Helixi129 – 1346Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KLXX-ray1.95A1-138[»]
ProteinModelPortaliO25103.
SMRiO25103. Positions 3-135.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO25103.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 2828TPR 1Add
BLAST
Repeati57 – 9438TPR 2Add
BLAST
Repeati97 – 13034TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
OMAiSIACEAN.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 4 hits.
[Graphical view]
SMARTiSM00671. SEL1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25103-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGGGTVKKD LKKAIQYYVK ACELNEMFGC LSLVSNSQIN KQKLFQYLSK
60 70 80 90 100
ACELNSGNGC RFLGDFYENG KYVKKDLRKA AQYYSKACGL NDQDGCLILG
110 120 130
YKQYAGKGVV KNEKQAVKTF EKACRLGSED ACGILNNY
Length:138
Mass (Da):15,346
Last modified:January 1, 1998 - v1
Checksum:i4149505C1BE623B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07408.1.
PIRiH64561.

Genome annotation databases

EnsemblBacteriaiAAD07408; AAD07408; HP_0336.
PATRICi20591907. VBIHelPyl33062_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07408.1 .
PIRi H64561.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KLX X-ray 1.95 A 1-138 [» ]
ProteinModelPortali O25103.
SMRi O25103. Positions 3-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3342N.
IntActi O25103. 50 interactions.
MINTi MINT-160080.
STRINGi 85962.HP0336.

Proteomic databases

PRIDEi O25103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07408 ; AAD07408 ; HP_0336 .
PATRICi 20591907. VBIHelPyl33062_0350.

Phylogenomic databases

eggNOGi COG0790.
OMAi SIACEAN.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPY:HP0336-MONOMER.

Miscellaneous databases

EvolutionaryTracei O25103.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF08238. Sel1. 4 hits.
[Graphical view ]
SMARTi SM00671. SEL1. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
    Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
    Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ANTIGENICITY.
  3. "The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein."
    Luethy L., Gruetter M.G., Mittl P.R.E.
    J. Biol. Chem. 277:10187-10193(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS), FUNCTION.

Entry informationi

Entry nameiHCPB_HELPY
AccessioniPrimary (citable) accession number: O25103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Antibodies against HcpB are present in sera from human patients infected by Helicobacter pylori.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3