O25098 (MIND_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septum site-determining protein MinD

Alternative name(s):
Cell division inhibitor MinD

Gene names

Name:	minD
Ordered Locus Names:	HP_0331

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings By similarity.
Subunit structure	Interacts with MinC and FtsZ By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ParA family. MinD subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Septation
Cellular component	Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	barrier septum site selection Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Septum site-determining protein MinD		PRO_0000201971
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O25098 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9E14766E8D309476	FASTA	268	29,294
	10 20 30 40 50 60 MAIVVTITSG KGGVGKSTTT ANLAIGLAES GKKVVAVDFD IGLRNLDMIL GLENRIVYDV 70 80 90 100 110 120 VDVMEKNCNL SQALITDKKT KNLSFLAASQ SKDKNILDKE KVAILINALR ADFDYILIDS 130 140 150 160 170 180 PAGIESGFEH AILHADMALV VVTPEVSSLR DSDRVVGIID AKSNRAKKGM EVHKHLIINR 190 200 210 220 230 240 LKPELVANGE MISIEEVLKI LCLPLIGIIP EDHHIISATN KGEPVIRTDC ESAKAYQRIT 250 260 RRILGEEVEY VEFKAKRGFF SALKGIFS

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07400.1.
PIR	C64561.
RefSeq	NP_207129.1. NC_000915.1. YP_006934259.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25098.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3247N.
MINT	MINT-161558.
STRING	85962.HP0331.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07400; AAD07400; HP_0331.
GeneID	13869518. 900172.
KEGG	heo:C694_01675. hpy:HP0331.
PATRIC	20591897. VBIHelPyl33062_0345.
Phylogenomic databases
eggNOG	COG2894.
KO	K03609.
OMA	RNLDMIL.
ProtClustDB	CLSK872336.
Family and domain databases
InterPro	IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom. IPR025501. MinD. IPR010223. MinD_bac-type. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR13696:SF1. PTHR13696:SF1. 1 hit.
Pfam	PF01656. CbiA. 1 hit. [Graphical view]
PIRSF	PIRSF003092. MinD. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR01968. minD_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MIND_HELPY

Accession

Primary (citable) accession number: O25098

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program