O25092 (FLGH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Flagellar L-ring protein

Alternative name(s):
Basal body L-ring protein

Gene names

Name:	flgH
Ordered Locus Names:	HP_0325

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation By similarity. HAMAP-Rule MF_00415
Subunit structure	The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod By similarity.
Subcellular location	Cell outer membrane By similarity. Bacterial flagellum basal body By similarity.
Sequence similarities	Belongs to the FlgH family.

Ontologies

Keywords
Cellular component	Bacterial flagellum Cell membrane Cell outer membrane Membrane
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ciliary or flagellar motility Inferred from electronic annotation. Source: HAMAP
Cellular_component	bacterial-type flagellum basal body, distal rod, L ring Inferred from electronic annotation. Source: InterPro cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 237	216	Flagellar L-ring protein HAMAP-Rule MF_00415		PRO_0000009451

Sequences

	Sequence		Length	Mass (Da)
	O25092 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: C0D1E43DDE42F6F9	FASTA	237	26,469
	10 20 30 40 50 60 MKKALYLGAV AFSVAFSMAS ANEPKIDFNP PNYVEETPSK EFIPELNKLG SLFGQGERPL 70 80 90 100 110 120 FADRRAMKPN DLITIIVSEK ASANYSSSKD YKSASGGNST PPRLTYNGLD ERKKKEAEYL 130 140 150 160 170 180 DDKNNYNFTK SSNNTNFKGG GSQKKSEDLE IVLSARIIKV LENGNYFIYG NKEVLVDGEK 190 200 210 220 230 QILKVSGVIR PYDIERNNTI QSKFLADAKI EYTNLGHLSD SNKKKFAADA METQMPY

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07392.1.
PIR	E64560.
RefSeq	NP_207123.1. NC_000915.1. YP_006934253.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O25092.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3206N.
MINT	MINT-161216.
STRING	85962.HP0325.
Protocols and materials databases
DNASU	900196.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07392; AAD07392; HP_0325.
GeneID	13869511. 900196.
KEGG	heo:C694_01645. hpy:HP0325.
PATRIC	20591883. VBIHelPyl33062_0339.
Phylogenomic databases
eggNOG	COG2063.
KO	K02393.
OMA	LEGPLGN.
ProtClustDB	PRK00249.
Family and domain databases
HAMAP	MF_00415. FlgH.
InterPro	IPR000527. Flag_Lring. [Graphical view]
Pfam	PF02107. FlgH. 1 hit. [Graphical view]
PRINTS	PR01008. FLGLRINGFLGH.
ProtoNet	Search...

Entry information

Entry name

FLGH_HELPY

Accession

Primary (citable) accession number: O25092

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program