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Protein
Submitted name:

Toxin-like outer membrane protein

Gene

HP_0289

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP0289-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Toxin-like outer membrane proteinImported
Gene namesi
Ordered Locus Names:HP_0289Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiO25063.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-7493139,EBI-7493139
HP_1542O260674EBI-7493139,EBI-7644202

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-3227N.
IntActiO25063. 14 interactions.
MINTiMINT-162201.
STRINGi85962.HP0289.

Structurei

3D structure databases

ProteinModelPortaliO25063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2620 – 2893274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiCOG5651. LUCA.
OMAiFNNANFN.
OrthoDBiEOG6RVFRD.

Family and domain databases

InterProiIPR005546. Autotransporte_beta.
IPR004311. Vacuolating_cytotoxin_put.
[Graphical view]
PfamiPF03077. VacA2. 3 hits.
[Graphical view]
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFKKKPKS IKRSHQNQKT ILKRPLWLMP LLISGFASGV YANNLWDLLN
60 70 80 90 100
PKVGGEYVHW VKGSQYCAWW EFAGCLKNVW GANHKGYDAG NAANYLSSQN
110 120 130 140 150
YQAISVGSGN ETGTYSLSGF TNYVGGNLTI NLGNSVVLDL SGSNSFTSYQ
160 170 180 190 200
GYNQGKDDVT FTVGAINLNG TLEVGNRVGS GAGTHTGTAT LNLNANKVNI
210 220 230 240 250
NSNINAYKTS QVNIGNANSV ITIGSVSLSG DVCSSLASVG IGANCSTSGP
260 270 280 290 300
SYSFKGTTNA TNTAFSNASG SFTFEENATF SGAKWNGGTY TFNKEFSATN
310 320 330 340 350
NTAFSSGSFN FKGVSSFNGT SFSNASYTFD NQATFQNSSF NGGTFTFNNQ
360 370 380 390 400
TNPTNNAQHP QIQNSSFSGN ATTLKGFVNF QQAFNNSNHQ LTIQNASFNN
410 420 430 440 450
ATFNNTGKIT IEKDASFNNT TFNTSVDTNN MSVTGGVTLS GKNDLKNGST
460 470 480 490 500
LDFGSSKITL AQGTTFNLTS LGSEKSVTIL NSSGGITYSN LLNHAINGLT
510 520 530 540 550
SALKTNESLS NPQSFAQGLW DIITYNGVTG QLLNENAATS KPTDSSPSKS
560 570 580 590 600
STNSTQVYQV GYKIGDTIYK LQETFSHNSI IIQALESGTY TPPPVINGSK
610 620 630 640 650
FDLSASNYIN ADMPWYDHKY YIPKSQNFTE SGTYYLPSVQ IWGSYTNSFK
660 670 680 690 700
QTFSANGSNL VIGYNSTWTD HNVSSSGTVS FGDTSGSALN GHCGPWPYYQ
710 720 730 740 750
CTGTTNGTYS AYHVYITANL RSGNRIGTGG AANLIFNGVD SINIANATIT
760 770 780 790 800
QHNAGIYSSS MTFSTQSMDN SQNLNGLNSN GKLSVYGTTF TNEAKDGKFI
810 820 830 840 850
FNAGQAVFEN TNFNGGSYQF SGDSLNFSNN NQFNSGSFEI SAKNASFNNA
860 870 880 890 900
NFNNSASFNF NNSNATTSFV GDFTNANSNL QIAGNAVFGN STNGSQNTAN
910 920 930 940 950
FNNTGSVNIS GNATFDNVVF NGPTNTSVKG QVTLNNITLK NLNAPLSFGD
960 970 980 990 1000
GTITFNAHSV INIAESITNG NPITLVSSSK EIEYNNAFSK NLWQLINYQG
1010 1020 1030 1040 1050
HGASSEKLVS SAGNGVYDVV YSFNNQTYNF QEVFSQNSIS IRRLGVNMVF
1060 1070 1080 1090 1100
DYVDMEKSDH LYYQNALGFM TYMPNSYNNN LGNANNTIYY YDKSIDFYAS
1110 1120 1130 1140 1150
GKTLFTKAEF SQTFTGQNSA IVFGAKSIWT SLSDAPQSNT IIRFGDNKGA
1160 1170 1180 1190 1200
GSNDASGHCW NLQCIGFITG HYEAQKIYIT GSIESGNRIS SGGGASLNFN
1210 1220 1230 1240 1250
GLQGILLTNA TLYNRAAGTQ SSSMNFISNS ANIQAQNSYF IDDTAQNGGN
1260 1270 1280 1290 1300
PNFSFNALNL DFSNSSFRGY VGKTQSVFKF NAKNAISFTN STNLSSGLYQ
1310 1320 1330 1340 1350
MQAKSVLFDN SNLSVSVGTS SIKANAINLS QNASINASNH STLELQGDLN
1360 1370 1380 1390 1400
VNDTSSLNLN QSTINVSNNA TINDYASLIA SNGSHLNFNG AVNFNSANIT
1410 1420 1430 1440 1450
TSLNNSSIVF KGAVSLGGQF NLSNNSSLDF QGSSAITSNT AFNFYDNAFS
1460 1470 1480 1490 1500
QSPITFHQAL DIKAPLSLGG NLLNPNNSSV LDLKNSQLVF GDQGSLNIAN
1510 1520 1530 1540 1550
IDLLSDLNDN KNRVYNIIQA DMNSNWYERI SFFGMHINDG IYDAKNQTYS
1560 1570 1580 1590 1600
FTNPLNNALK ITESFKDNQL SVTLSQIPGI KNTLYNIGSE IFNYQKVYNN
1610 1620 1630 1640 1650
ANGVYSYSDD AQGVFYLTSN VKGYYNPNQS YQASGSNNTT KNNNLTSESS
1660 1670 1680 1690 1700
IISQTYNAQG NPISALHIYN KGYNFNNIKA LGQMALKLYP EIKKVLGNDF
1710 1720 1730 1740 1750
SPSSLNALNS NALNQLTKLI TPNDWKNINE LIDNANNSVV QNFNNGTLIV
1760 1770 1780 1790 1800
GATQIGQTDT NSAVVFGGLG YQTPCDYTDI VCQKFRGTYL GQLLESSSAD
1810 1820 1830 1840 1850
LGYIDTTFNA KEIYLTGTLG SGNAWGTGGS ASVTFNSQTS LILNQANIVS
1860 1870 1880 1890 1900
SQTDGIFSML GQEGINKVFN QAGLANILGE VAVQSINKAG GLGNLIVNTL
1910 1920 1930 1940 1950
GSNSVIGGYL TPEQKNQTLS QLLGQNNFDN LMNDSGLNTA IKDLIRQKLG
1960 1970 1980 1990 2000
FWTGLVGGLA GLGGIDLQNP EKLIGSMSIN DLLSKKGLFN QITGFISAND
2010 2020 2030 2040 2050
IGQVISVMLQ DIVKPSNALK NDVAALGKQM IGEFLGQDTL NSLESLLQNQ
2060 2070 2080 2090 2100
QIKSVLDKVL AAKGLGPIYE QGLGDLIPNL GKKGLFAPYG LSQVWQKGDF
2110 2120 2130 2140 2150
SFNAQGNVFV QNSTFSNANG GTLSFNAGNS LIFAGNNHIA FTNHAGTLQL
2160 2170 2180 2190 2200
LSDQVSNINI TTLNASNGLK INAANNNVSV SQGNLFVSAS CAQQSDPTTA
2210 2220 2230 2240 2250
NIANPCALSA QSTNGASSNN ASNNAPIALS NNDESLMVAA NDFNFSGNIY
2260 2270 2280 2290 2300
ANGVVDFSKI KGSANIKNLY LYNNAQFQAN NLTISNQAVL EKNASFVTNN
2310 2320 2330 2340 2350
LNIQGAFNNN ATQKIEVLQN LVIASNASLS TGIYGLEVGG ALNNSGAIHF
2360 2370 2380 2390 2400
NLENTQTPTP LIQAEGIINL NTTQTPFMNV NNSMANNTTY TLLKSSRYID
2410 2420 2430 2440 2450
YNINPNSLQS YLNLYTLINI NGNHIEEKNG ALTYLGQRVL LQDKGLLLSV
2460 2470 2480 2490 2500
ALPNSNNASQ NNILSLSVLY NQVKMSCGDK AMDFTPPTLQ DYIVGIQGQS
2510 2520 2530 2540 2550
ALNQIEAVGG NAIKWLSTLM METKENPFFA PIYLKNHSLN EILGVTKDLQ
2560 2570 2580 2590 2600
NTASLISNPN FRDNATNLLE LASYTQQTSR LTKLSDFRSR EGESDFSLLE
2610 2620 2630 2640 2650
LKNKRFSDPN PEVFVKYSQL SKHPNNLWVQ GVGGASFISG GNGTLYGLNA
2660 2670 2680 2690 2700
GYDRLVKNVI LGGYVAYGYS DFNGNIMHSL GNNVDVGMYA RAFLKRNEFT
2710 2720 2730 2740 2750
LSANETYGGN ATSINSSNSL LSVLNQRYNY NTWTTSVNGN YGYDFMFKQK
2760 2770 2780 2790 2800
SVVLKPQVGL SYHFIGLSGM KGNDAAYKQF LMHSNPSNES VLTLNMGLES
2810 2820 2830 2840 2850
RKYFGKNSYY FVTARLGRDL LIKSKGSNTV RFVGENTLLY RKGEVFNTFA
2860 2870 2880 2890
SVITGGEMHL WRLVYVNAGV GLKMGLQYQD INITGNVGMR VAF
Length:2,893
Mass (Da):311,288
Last modified:January 1, 1998 - v1
Checksum:iA319D9CFC73BB27D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07355.1.
PIRiA64556.
RefSeqiNP_207087.1. NC_000915.1.
WP_000713712.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07355; AAD07355; HP_0289.
GeneIDi899197.
KEGGiheo:C694_01460.
hpy:HP0289.
PATRICi20591805. VBIHelPyl33062_0300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07355.1.
PIRiA64556.
RefSeqiNP_207087.1. NC_000915.1.
WP_000713712.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3227N.
IntActiO25063. 14 interactions.
MINTiMINT-162201.
STRINGi85962.HP0289.

Proteomic databases

PaxDbiO25063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07355; AAD07355; HP_0289.
GeneIDi899197.
KEGGiheo:C694_01460.
hpy:HP0289.
PATRICi20591805. VBIHelPyl33062_0300.

Phylogenomic databases

eggNOGiCOG5651. LUCA.
OMAiFNNANFN.
OrthoDBiEOG6RVFRD.

Enzyme and pathway databases

BioCyciHPY:HP0289-MONOMER.

Family and domain databases

InterProiIPR005546. Autotransporte_beta.
IPR004311. Vacuolating_cytotoxin_put.
[Graphical view]
PfamiPF03077. VacA2. 3 hits.
[Graphical view]
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695Imported.

Entry informationi

Entry nameiO25063_HELPY
AccessioniPrimary (citable) accession number: O25063
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.