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O25021

- HCPE_HELPY

UniProt

O25021 - HCPE_HELPY

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Protein
Putative beta-lactamase HcpE
Gene
hcpE, HP_0235
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP0235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpE (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein E
Gene namesi
Name:hcpE
Ordered Locus Names:HP_0235
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 355333Putative beta-lactamase HcpE
PRO_0000013200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 62 Reviewed prediction
Disulfide bondi90 ↔ 98 Reviewed prediction
Disulfide bondi126 ↔ 134 Reviewed prediction
Disulfide bondi160 ↔ 168 Reviewed prediction
Disulfide bondi197 ↔ 205 Reviewed prediction
Disulfide bondi234 ↔ 242 Reviewed prediction
Disulfide bondi270 ↔ 278 Reviewed prediction
Disulfide bondi306 ↔ 314 Reviewed prediction
Disulfide bondi338 ↔ 346 Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO25021.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0235.

Structurei

3D structure databases

ProteinModelPortaliO25021.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 6034TPR 1
Add
BLAST
Repeati63 – 9634TPR 2
Add
BLAST
Repeati98 – 13134TPR 3
Add
BLAST
Repeati132 – 16635TPR 4
Add
BLAST
Repeati202 – 24039TPR 5
Add
BLAST
Repeati245 – 27531TPR 6
Add
BLAST
Repeati276 – 31136TPR 7
Add
BLAST
Repeati312 – 34433TPR 8
Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiKENAIMI.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF08238. Sel1. 8 hits.
[Graphical view]
SMARTiSM00671. SEL1. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O25021-1 [UniParc]FASTAAdd to Basket

« Hide

MGVKFLKILV CGLFFWSLNA HLWGKQDNSF LGVAEKAYKS GNYSKATSYF    50
KKACNDGVSE GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG 100
LGGLYDEGLG TTQNYQEAID AYAKACVLKH PESCYNLGII YDRKIKGNAD 150
QAVTYYQKSC NFDMAKGCYV LGVAYEKGFL EVKQSNHKAV IYYLKACRLD 200
DGQACRALGS LFENGDAGLD EDFEVAFDYL QKACGLNNSG GCASLGSMYM 250
LGRYVKKDPQ KAFNFFKQAC DMGSAVSCSR MGFMYSQGDA VPKDLRKALD 300
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT 350
KLRGY 355
Length:355
Mass (Da):39,399
Last modified:January 1, 1998 - v1
Checksum:i12B6CB9E295BD628
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07303.1.
PIRiC64549.
RefSeqiNP_207033.1. NC_000915.1.
YP_006934161.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07303; AAD07303; HP_0235.
GeneIDi13869418.
898928.
KEGGiheo:C694_01185.
hpy:HP0235.
PATRICi20591695. VBIHelPyl33062_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07303.1 .
PIRi C64549.
RefSeqi NP_207033.1. NC_000915.1.
YP_006934161.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25021.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0235.

Proteomic databases

PRIDEi O25021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07303 ; AAD07303 ; HP_0235 .
GeneIDi 13869418.
898928.
KEGGi heo:C694_01185.
hpy:HP0235.
PATRICi 20591695. VBIHelPyl33062_0246.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi KENAIMI.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPY:HP0235-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF08238. Sel1. 8 hits.
[Graphical view ]
SMARTi SM00671. SEL1. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
    Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
    Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ANTIGENICITY.

Entry informationi

Entry nameiHCPE_HELPY
AccessioniPrimary (citable) accession number: O25021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Antibodies against HcpE are present in sera from human patients infected by Helicobacter pylori.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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