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O25021 (HCPE_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpE

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein E
Gene names
Name:hcpE
Ordered Locus Names:HP_0235
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted Potential.

Miscellaneous

Antibodies against HcpE are present in sera from human patients infected by Helicobacter pylori.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 8 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 355333Putative beta-lactamase HcpE
PRO_0000013200

Regions

Repeat27 – 6034TPR 1
Repeat63 – 9634TPR 2
Repeat98 – 13134TPR 3
Repeat132 – 16635TPR 4
Repeat202 – 24039TPR 5
Repeat245 – 27531TPR 6
Repeat276 – 31136TPR 7
Repeat312 – 34433TPR 8

Amino acid modifications

Disulfide bond54 ↔ 62 Potential
Disulfide bond90 ↔ 98 Potential
Disulfide bond126 ↔ 134 Potential
Disulfide bond160 ↔ 168 Potential
Disulfide bond197 ↔ 205 Potential
Disulfide bond234 ↔ 242 Potential
Disulfide bond270 ↔ 278 Potential
Disulfide bond306 ↔ 314 Potential
Disulfide bond338 ↔ 346 Potential

Sequences

Sequence LengthMass (Da)Tools
O25021 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 12B6CB9E295BD628

FASTA35539,399
        10         20         30         40         50         60 
MGVKFLKILV CGLFFWSLNA HLWGKQDNSF LGVAEKAYKS GNYSKATSYF KKACNDGVSE 

        70         80         90        100        110        120 
GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG LGGLYDEGLG TTQNYQEAID 

       130        140        150        160        170        180 
AYAKACVLKH PESCYNLGII YDRKIKGNAD QAVTYYQKSC NFDMAKGCYV LGVAYEKGFL 

       190        200        210        220        230        240 
EVKQSNHKAV IYYLKACRLD DGQACRALGS LFENGDAGLD EDFEVAFDYL QKACGLNNSG 

       250        260        270        280        290        300 
GCASLGSMYM LGRYVKKDPQ KAFNFFKQAC DMGSAVSCSR MGFMYSQGDA VPKDLRKALD 

       310        320        330        340        350 
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT KLRGY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07303.1.
PIRC64549.
RefSeqNP_207033.1. NC_000915.1.
YP_006934161.1. NC_018939.1.

3D structure databases

ProteinModelPortalO25021.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0235.

Proteomic databases

PRIDEO25021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07303; AAD07303; HP_0235.
GeneID13869418.
898928.
KEGGheo:C694_01185.
hpy:HP0235.
PATRIC20591695. VBIHelPyl33062_0246.

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAKENAIMI.
OrthoDBEOG6TJ7WZ.
ProtClustDBCLSK495931.

Enzyme and pathway databases

BioCycHPY:HP0235-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF08238. Sel1. 8 hits.
[Graphical view]
SMARTSM00671. SEL1. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPE_HELPY
AccessionPrimary (citable) accession number: O25021
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names