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O25021

- HCPE_HELPY

UniProt

O25021 - HCPE_HELPY

Protein

Putative beta-lactamase HcpE

Gene

hcpE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPY:HP0235-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-lactamase HcpE (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein E
    Gene namesi
    Name:hcpE
    Ordered Locus Names:HP_0235
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 355333Putative beta-lactamase HcpEPRO_0000013200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 62Sequence Analysis
    Disulfide bondi90 ↔ 98Sequence Analysis
    Disulfide bondi126 ↔ 134Sequence Analysis
    Disulfide bondi160 ↔ 168Sequence Analysis
    Disulfide bondi197 ↔ 205Sequence Analysis
    Disulfide bondi234 ↔ 242Sequence Analysis
    Disulfide bondi270 ↔ 278Sequence Analysis
    Disulfide bondi306 ↔ 314Sequence Analysis
    Disulfide bondi338 ↔ 346Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO25021.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0235.

    Structurei

    3D structure databases

    ProteinModelPortaliO25021.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati27 – 6034TPR 1Add
    BLAST
    Repeati63 – 9634TPR 2Add
    BLAST
    Repeati98 – 13134TPR 3Add
    BLAST
    Repeati132 – 16635TPR 4Add
    BLAST
    Repeati202 – 24039TPR 5Add
    BLAST
    Repeati245 – 27531TPR 6Add
    BLAST
    Repeati276 – 31136TPR 7Add
    BLAST
    Repeati312 – 34433TPR 8Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 8 TPR repeats.Curated

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiKENAIMI.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF08238. Sel1. 8 hits.
    [Graphical view]
    SMARTiSM00671. SEL1. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O25021-1 [UniParc]FASTAAdd to Basket

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    MGVKFLKILV CGLFFWSLNA HLWGKQDNSF LGVAEKAYKS GNYSKATSYF    50
    KKACNDGVSE GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG 100
    LGGLYDEGLG TTQNYQEAID AYAKACVLKH PESCYNLGII YDRKIKGNAD 150
    QAVTYYQKSC NFDMAKGCYV LGVAYEKGFL EVKQSNHKAV IYYLKACRLD 200
    DGQACRALGS LFENGDAGLD EDFEVAFDYL QKACGLNNSG GCASLGSMYM 250
    LGRYVKKDPQ KAFNFFKQAC DMGSAVSCSR MGFMYSQGDA VPKDLRKALD 300
    NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT 350
    KLRGY 355
    Length:355
    Mass (Da):39,399
    Last modified:January 1, 1998 - v1
    Checksum:i12B6CB9E295BD628
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07303.1.
    PIRiC64549.
    RefSeqiNP_207033.1. NC_000915.1.
    YP_006934161.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07303; AAD07303; HP_0235.
    GeneIDi13869418.
    898928.
    KEGGiheo:C694_01185.
    hpy:HP0235.
    PATRICi20591695. VBIHelPyl33062_0246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07303.1 .
    PIRi C64549.
    RefSeqi NP_207033.1. NC_000915.1.
    YP_006934161.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25021.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0235.

    Proteomic databases

    PRIDEi O25021.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07303 ; AAD07303 ; HP_0235 .
    GeneIDi 13869418.
    898928.
    KEGGi heo:C694_01185.
    hpy:HP0235.
    PATRICi 20591695. VBIHelPyl33062_0246.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi KENAIMI.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPY:HP0235-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF08238. Sel1. 8 hits.
    [Graphical view ]
    SMARTi SM00671. SEL1. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals."
      Mittl P.R.E., Luethy L., Reinhardt C., Joller H.
      Clin. Diagn. Lab. Immunol. 10:542-545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ANTIGENICITY.

    Entry informationi

    Entry nameiHCPE_HELPY
    AccessioniPrimary (citable) accession number: O25021
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Antibodies against HcpE are present in sera from human patients infected by Helicobacter pylori.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3