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Protein

Putative beta-lactamase HcpE

Gene

hcpE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

Miscellaneous

Antibodies against HcpE are present in sera from human patients infected by Helicobacter pylori.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP0235-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpE (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein E
Gene namesi
Name:hcpE
Ordered Locus Names:HP_0235
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001320023 – 355Putative beta-lactamase HcpEAdd BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 62Sequence analysis
Disulfide bondi90 ↔ 98Sequence analysis
Disulfide bondi126 ↔ 134Sequence analysis
Disulfide bondi160 ↔ 168Sequence analysis
Disulfide bondi197 ↔ 205Sequence analysis
Disulfide bondi234 ↔ 242Sequence analysis
Disulfide bondi270 ↔ 278Sequence analysis
Disulfide bondi306 ↔ 314Sequence analysis
Disulfide bondi338 ↔ 346Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO25021
PRIDEiO25021

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0235

Structurei

3D structure databases

ProteinModelPortaliO25021
SMRiO25021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 60TPR 1Add BLAST34
Repeati63 – 96TPR 2Add BLAST34
Repeati98 – 131TPR 3Add BLAST34
Repeati132 – 166TPR 4Add BLAST35
Repeati202 – 240TPR 5Add BLAST39
Repeati245 – 275TPR 6Add BLAST31
Repeati276 – 311TPR 7Add BLAST36
Repeati312 – 344TPR 8Add BLAST33

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiENOG4105EUU Bacteria
COG0790 LUCA
KOiK07126
OMAiDEVGCFA

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF08238 Sel1, 7 hits
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00671 SEL1, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O25021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVKFLKILV CGLFFWSLNA HLWGKQDNSF LGVAEKAYKS GNYSKATSYF
60 70 80 90 100
KKACNDGVSE GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG
110 120 130 140 150
LGGLYDEGLG TTQNYQEAID AYAKACVLKH PESCYNLGII YDRKIKGNAD
160 170 180 190 200
QAVTYYQKSC NFDMAKGCYV LGVAYEKGFL EVKQSNHKAV IYYLKACRLD
210 220 230 240 250
DGQACRALGS LFENGDAGLD EDFEVAFDYL QKACGLNNSG GCASLGSMYM
260 270 280 290 300
LGRYVKKDPQ KAFNFFKQAC DMGSAVSCSR MGFMYSQGDA VPKDLRKALD
310 320 330 340 350
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT

KLRGY
Length:355
Mass (Da):39,399
Last modified:January 1, 1998 - v1
Checksum:i12B6CB9E295BD628
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07303.1
PIRiC64549
RefSeqiNP_207033.1, NC_000915.1
WP_000538261.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07303; AAD07303; HP_0235
GeneIDi898928
KEGGiheo:C694_01185
hpy:HP0235
PATRICifig|85962.47.peg.254

Similar proteinsi

Entry informationi

Entry nameiHCPE_HELPY
AccessioniPrimary (citable) accession number: O25021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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