Peptide methionine sulfoxide reductase msrA/msrB

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Reviewed, UniProtKB/Swiss-Prot O25011 (MSRAB_HELPY)

Last modified June 16, 2009. Version 64. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA/msrB
Including the following 2 domains:
    1- Recommended name:
            Peptide methionine sulfoxide reductase msrA
                Short name=Protein-methionine-S-oxide reductase
              EC=1.8.4.11
        Alternative name(s):
            Peptide-methionine (S)-S-oxide reductase
              Short name=Peptide Met(O) reductase
    2- Recommended name:
            Peptide methionine sulfoxide reductase msrB
              EC=1.8.4.12
        Alternative name(s):
            Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrAB
Synonyms:	msrA
Ordered Locus Names:	HP_0224

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

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Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sequence similarities

In the N-terminal section; belongs to the msrA Met sulfoxide reductase family.

In the C-terminal section; belongs to the msrB Met sulfoxide reductase family.

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Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 359

359

Peptide methionine sulfoxide reductase msrA/msrB HAMAP MF_01400

PRO_0000138515

Regions

Region

36 – 189

154

Peptide methionine sulfoxide reductase A HAMAP MF_01400

Region

206 – 329

124

Peptide methionine sulfoxide reductase B HAMAP MF_01400

Sites

Active site

By similarity

Active site

318

By similarity

Experimental info

Sequence conflict

N → I in AAC24211. Ref.2

Sequence conflict

A → L in AAC24211. Ref.2

Sequence conflict

S → N in AAC24211. Ref.2

Sequence conflict

135

A → T in AAC24211. Ref.2

Sequence conflict

142

H → N in AAC24211. Ref.2

Sequence conflict

170

E → K in AAC24211. Ref.2

Sequence conflict

181

S → G in AAC24211. Ref.2

Sequence conflict

198

D → S in AAC24211. Ref.2

Sequence conflict

346

K → R in AAC24211. Ref.2

Sequence conflict

354

N → Q in AAC24211. Ref.2

Sequence conflict

358

S → T in AAC24211. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

O25011-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D481FAC5C60927B3
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FASTA

359

41,275

        10         20         30         40         50         60 
MKVLSYLKNF YLFLAIGAIM QASENMGSQH QKTDERVIYL AGGCFWGLEA YMERIYGVID 

        70         80         90        100        110        120 
ASSGYANGKT SSTNYEKLHE SDHAESVKVI YDPKKISLDK LLRYYFKVVD PVSVNKQGND 

       130        140        150        160        170        180 
VGRQYRTGIY YVNSADKEVI DHALKALQKE VKGKIAIEVE PLKNYVRAEE YHQDYLKKHP 

       190        200        210        220        230        240 
SGYCHIDLKK ADEVIVDDDK YTKPSDEVLK KKLTKLQYEV TQNKHTEKPF ENEYYNKEEE 

       250        260        270        280        290        300 
GIYVDITTGE PLFSSADKYD SGCGWPSFSK PINKDVVKYE DDESLNRKRI EVLSRIGKAH 

       310        320        330        340        350 
LGHVFNDGPK ELGGLRYCIN SAALRFIPLK DMEKEGYGEF IPYIKKGELK KYINDKKSH

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Extracellular release of antigenic proteins by Helicobacter pylori." Cao P., McClain M.S., Forsyth M.H., Cover T.L. Infect. Immun. 66:2984-2986(1998) [PubMed: 9596777] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49503 / 60190.

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Cross-references

Sequence databases
	AE000511 Genomic DNA. Translation: AAD07291.1. AF053709 Genomic DNA. Translation: AAC24211.1.
PIR	H64547.
RefSeq	NP_207022.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3282N.
Genome annotation databases
GeneID	900130.
GenomeReviews	Gene locus HP_0224 in contig AE000511_GR.
KEGG	hpy:HP0224.
NMPDR	fig\|85962.1.peg.220.
TIGR	HP_0224.
Phylogenomic databases
HOGENOM	O25011.
OMA	O25011. DERVIYL.
Enzyme and pathway databases
BRENDA	1.8.4.11. 1131. 1.8.4.12. 1131.
Family and domain databases
HAMAP	MF_01400. Fused. [Tree] MF_01401. Fused. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

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Entry information

Entry name

MSRAB_HELPY

Accession

Primary (citable) accession number: O25011
Secondary accession number(s): O85224

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents