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O25004

- CDSA_HELPY

UniProt

O25004 - CDSA_HELPY

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Protein
Phosphatidate cytidylyltransferase
Gene
cdsA, HP_0215
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP0215-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:HP_0215
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Phosphatidate cytidylyltransferase
PRO_0000090737Add
BLAST

Proteomic databases

PRIDEiO25004.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0215.

Structurei

3D structure databases

ProteinModelPortaliO25004.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
KOiK00981.
OMAiMHFLLYF.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25004-1 [UniParc]FASTAAdd to Basket

« Hide

MKEELFKEKS RYITGFVLII VADLILYADN LLLFWAVLGG IYAVGFSEAL    50
RLFQVKASFS LYLILVLSWV AAYFNGRPIE CALISAMVMA SVIAYQKAHH 100
SEAILPFLYP GVGFFALFGV YKDFGAVAII WLLVVVVASD VGAFFGGKLL 150
GKTPFTPTSP NKTLEGALIG VVLASVLGSF VGMGKLSGGF FMALFFSFLI 200
ALVAVFGDLY ESYLKRKVGI KDSGKILPGH GGVLDRLDSM LFGALGLHAL 250
LYFLEIWKET AVFLGD 266
Length:266
Mass (Da):28,899
Last modified:January 1, 1998 - v1
Checksum:i4995F8D1B92904F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07283.1.
PIRiG64546.
RefSeqiNP_207013.1. NC_000915.1.
YP_006934141.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07283; AAD07283; HP_0215.
GeneIDi13869397.
899163.
KEGGiheo:C694_01085.
hpy:HP0215.
PATRICi20591653. VBIHelPyl33062_0226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07283.1 .
PIRi G64546.
RefSeqi NP_207013.1. NC_000915.1.
YP_006934141.1. NC_018939.1.

3D structure databases

ProteinModelPortali O25004.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0215.

Proteomic databases

PRIDEi O25004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07283 ; AAD07283 ; HP_0215 .
GeneIDi 13869397.
899163.
KEGGi heo:C694_01085.
hpy:HP0215.
PATRICi 20591653. VBIHelPyl33062_0226.

Phylogenomic databases

eggNOGi COG0575.
KOi K00981.
OMAi MHFLLYF.
OrthoDBi EOG6TBHJT.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci HPY:HP0215-MONOMER.

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCDSA_HELPY
AccessioniPrimary (citable) accession number: O25004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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