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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciHPY:HP0215-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:HP_0215
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Phosphatidate cytidylyltransferasePRO_0000090737Add
BLAST

Proteomic databases

PRIDEiO25004.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0215.

Structurei

3D structure databases

ProteinModelPortaliO25004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
KOiK00981.
OMAiASVIAYQ.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O25004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEELFKEKS RYITGFVLII VADLILYADN LLLFWAVLGG IYAVGFSEAL
60 70 80 90 100
RLFQVKASFS LYLILVLSWV AAYFNGRPIE CALISAMVMA SVIAYQKAHH
110 120 130 140 150
SEAILPFLYP GVGFFALFGV YKDFGAVAII WLLVVVVASD VGAFFGGKLL
160 170 180 190 200
GKTPFTPTSP NKTLEGALIG VVLASVLGSF VGMGKLSGGF FMALFFSFLI
210 220 230 240 250
ALVAVFGDLY ESYLKRKVGI KDSGKILPGH GGVLDRLDSM LFGALGLHAL
260
LYFLEIWKET AVFLGD
Length:266
Mass (Da):28,899
Last modified:December 31, 1997 - v1
Checksum:i4995F8D1B92904F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07283.1.
PIRiG64546.
RefSeqiNP_207013.1. NC_000915.1.
YP_006934141.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07283; AAD07283; HP_0215.
GeneIDi13869397.
899163.
KEGGiheo:C694_01085.
hpy:HP0215.
PATRICi20591653. VBIHelPyl33062_0226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07283.1.
PIRiG64546.
RefSeqiNP_207013.1. NC_000915.1.
YP_006934141.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO25004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0215.

Proteomic databases

PRIDEiO25004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07283; AAD07283; HP_0215.
GeneIDi13869397.
899163.
KEGGiheo:C694_01085.
hpy:HP0215.
PATRICi20591653. VBIHelPyl33062_0226.

Phylogenomic databases

eggNOGiCOG0575.
KOiK00981.
OMAiASVIAYQ.
OrthoDBiEOG6TBHJT.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
BioCyciHPY:HP0215-MONOMER.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCDSA_HELPY
AccessioniPrimary (citable) accession number: O25004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: December 31, 1997
Last modified: January 6, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.