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O25004

- CDSA_HELPY

UniProt

O25004 - CDSA_HELPY

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BioCyciHPY:HP0215-MONOMER.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    Ordered Locus Names:HP_0215
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Phosphatidate cytidylyltransferasePRO_0000090737Add
    BLAST

    Proteomic databases

    PRIDEiO25004.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0215.

    Structurei

    3D structure databases

    ProteinModelPortaliO25004.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    KOiK00981.
    OMAiMHFLLYF.
    OrthoDBiEOG6TBHJT.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O25004-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEELFKEKS RYITGFVLII VADLILYADN LLLFWAVLGG IYAVGFSEAL    50
    RLFQVKASFS LYLILVLSWV AAYFNGRPIE CALISAMVMA SVIAYQKAHH 100
    SEAILPFLYP GVGFFALFGV YKDFGAVAII WLLVVVVASD VGAFFGGKLL 150
    GKTPFTPTSP NKTLEGALIG VVLASVLGSF VGMGKLSGGF FMALFFSFLI 200
    ALVAVFGDLY ESYLKRKVGI KDSGKILPGH GGVLDRLDSM LFGALGLHAL 250
    LYFLEIWKET AVFLGD 266
    Length:266
    Mass (Da):28,899
    Last modified:January 1, 1998 - v1
    Checksum:i4995F8D1B92904F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07283.1.
    PIRiG64546.
    RefSeqiNP_207013.1. NC_000915.1.
    YP_006934141.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07283; AAD07283; HP_0215.
    GeneIDi13869397.
    899163.
    KEGGiheo:C694_01085.
    hpy:HP0215.
    PATRICi20591653. VBIHelPyl33062_0226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07283.1 .
    PIRi G64546.
    RefSeqi NP_207013.1. NC_000915.1.
    YP_006934141.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O25004.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0215.

    Proteomic databases

    PRIDEi O25004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07283 ; AAD07283 ; HP_0215 .
    GeneIDi 13869397.
    899163.
    KEGGi heo:C694_01085.
    hpy:HP0215.
    PATRICi 20591653. VBIHelPyl33062_0226.

    Phylogenomic databases

    eggNOGi COG0575.
    KOi K00981.
    OMAi MHFLLYF.
    OrthoDBi EOG6TBHJT.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    BioCyci HPY:HP0215-MONOMER.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiCDSA_HELPY
    AccessioniPrimary (citable) accession number: O25004
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3