O25004 (CDSA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	HP_0215

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Phosphatidate cytidylyltransferase		PRO_0000090737
Regions
	Transmembrane	16 – 36	21	Helical; Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O25004 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4995F8D1B92904F4	FASTA	266	28,899
	10 20 30 40 50 60 MKEELFKEKS RYITGFVLII VADLILYADN LLLFWAVLGG IYAVGFSEAL RLFQVKASFS 70 80 90 100 110 120 LYLILVLSWV AAYFNGRPIE CALISAMVMA SVIAYQKAHH SEAILPFLYP GVGFFALFGV 130 140 150 160 170 180 YKDFGAVAII WLLVVVVASD VGAFFGGKLL GKTPFTPTSP NKTLEGALIG VVLASVLGSF 190 200 210 220 230 240 VGMGKLSGGF FMALFFSFLI ALVAVFGDLY ESYLKRKVGI KDSGKILPGH GGVLDRLDSM 250 260 LFGALGLHAL LYFLEIWKET AVFLGD

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07283.1.
PIR	G64546.
RefSeq	NP_207013.1. NC_000915.1.
3D structure databases
ProteinModelPortal	O25004.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899163.
GenomeReviews	Gene locus HP_0215 in contig AE000511_GR.
KEGG	hpy:HP0215.
NMPDR	fig|85962.1.peg.211.
PATRIC	20591653. VBIHelPyl33062_0226.
TIGR	HP_0215.
Phylogenomic databases
HOGENOM	HBG732679.
OMA	FGDLYES.
ProtClustDB	CLSK872300.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_HELPY

Accession

Primary (citable) accession number: O25004

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program