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Protein

Phosphate acyltransferase

Gene

plsX

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible formation of acyl-phosphate (acyl-PO4) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein].UniRule annotation

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
  2. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acyltransferaseUniRule annotation (EC:2.3.1.n2UniRule annotation)
Alternative name(s):
Acyl-ACP phosphotransacylaseUniRule annotation
Acyl-[acyl-carrier-protein]--phosphate acyltransferaseUniRule annotation
Phosphate-acyl-ACP acyltransferaseUniRule annotation
Gene namesi
Name:plsXUniRule annotation
Ordered Locus Names:HP_0201
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation
Note: Associated with the membrane possibly through PlsY.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Phosphate acyltransferasePRO_0000189887Add
BLAST

Interactioni

Subunit structurei

Homodimer. Probably interacts with PlsY.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP0201.

Structurei

3D structure databases

ProteinModelPortaliO24993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0416.
KOiK03621.
OMAiKFCLRTM.
OrthoDBiEOG68H88P.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00019. PlsX.
InterProiIPR003664. FA_synthesis.
IPR024084. IsoPropMal-DH-like_dom.
IPR012281. Phospholipid_synth_PlsX-like.
[Graphical view]
PfamiPF02504. FA_synthesis. 1 hit.
[Graphical view]
PIRSFiPIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMsiTIGR00182. plsX. 1 hit.

Sequencei

Sequence statusi: Complete.

O24993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVIDLMGA DHGVLPVIEG VSRALENKSF STVLVGDKDK ATPFISKELA
60 70 80 90 100
SKVEMIHTQD YIKMEEAATE AIKRKESSIY LGMDILKNGA DALISAGHSG
110 120 130 140 150
ATMGLATLRL GRIKGVERPA ICTLMPSVGK RPSVLLDAGA NTDCKPEYLI
160 170 180 190 200
DFALMGYEYA KSVLHYDSPK VGLLSNGEED IKGNMLVKET HKMLKAYDFF
210 220 230 240 250
YGNVEGSDIF KGVVDVVVCD GFMGNVVLKT TEGVASAIGS IFKDEIKSSF
260 270 280 290 300
KSKMGALMLK NAFDILKQKT DYAEYGGAPL LGVNKSVIIS HGKSNARAIE
310 320 330
CAIYQAISAV ESQVCLRITQ AFESLKPSVS QSDQQDA
Length:337
Mass (Da):36,352
Last modified:May 30, 2000 - v2
Checksum:i7916CD4F5911B23C
GO

Sequence cautioni

The sequence AAD07269.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07269.1. Different initiation.
PIRiA64545.
RefSeqiNP_207000.1. NC_000915.1.
YP_006934124.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07269; AAD07269; HP_0201.
GeneIDi13869380.
898919.
KEGGiheo:C694_01000.
hpy:HP0201.
PATRICi20591623. VBIHelPyl33062_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07269.1. Different initiation.
PIRiA64545.
RefSeqiNP_207000.1. NC_000915.1.
YP_006934124.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO24993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07269; AAD07269; HP_0201.
GeneIDi13869380.
898919.
KEGGiheo:C694_01000.
hpy:HP0201.
PATRICi20591623. VBIHelPyl33062_0211.

Phylogenomic databases

eggNOGiCOG0416.
KOiK03621.
OMAiKFCLRTM.
OrthoDBiEOG68H88P.

Enzyme and pathway databases

UniPathwayiUPA00085.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00019. PlsX.
InterProiIPR003664. FA_synthesis.
IPR024084. IsoPropMal-DH-like_dom.
IPR012281. Phospholipid_synth_PlsX-like.
[Graphical view]
PfamiPF02504. FA_synthesis. 1 hit.
[Graphical view]
PIRSFiPIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMsiTIGR00182. plsX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPLSX_HELPY
AccessioniPrimary (citable) accession number: O24993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: February 4, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.