Reviewed, UniProtKB/Swiss-Prot O24991 (LPXD_HELPY)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
    EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	HP_0196

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase HAMAP MF_00523		PRO_0000059679

Sequences

	Sequence		Length	Mass (Da)
	O24991-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 17DAED0C39423497	FASTA	336	36,646
	10 20 30 40 50 60 MKLSELLNAY SIETEFSNDF EVHALAELNK ATPNDISYID QARYLKLLKD SKAGAVFIRK 70 80 90 100 110 120 KESSKVPKRM QALVVDNPHL AFAKASHAFK IPFFKNPESV NEPKHFERVT IMPNVVIGEG 130 140 150 160 170 180 VEIGENSLIY PGVVIADGVK IGKNCILYPR VTLYQNTILE DNVTIHAGSV IGGDGFGYAH 190 200 210 220 230 240 TALGEHVKIE HVGIVRIQKN VEIGANTAID RAVFGETLIK EGVKIDNLVQ IGHNCVLGEH 250 260 270 280 290 300 SIVVSQVGLS GSTTTGRNVV FGGQVGIGGH LHVGEFTQIG GKSAVGKDLP PNTNFAGAIP 310 320 330 AMEIHEWHHF LAHLRTNFRK QQKTSLLQKA KGFFKS

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07263.1.
PIR	D64544.
RefSeq	NP_206995.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3246N.
Genome annotation databases
GeneID	900138.
GenomeReviews	Gene locus HP_0196 in contig AE000511_GR.
KEGG	hpy:HP0196.
NMPDR	fig|85962.1.peg.193.
TIGR	HP_0196.
Phylogenomic databases
HOGENOM	O24991.
OMA	CFVGKNT
Family and domain databases
HAMAP	MF_00523. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
Pfam	PF00132. Hexapep. 9 hits. PF04613. LpxD. 1 hit. [Graphical view]
TIGRFAMs	TIGR01853. lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_HELPY

Accession

Primary (citable) accession number: O24991

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)