O24989 (Y189_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0114 protein HP_0189

Gene names

Ordered Locus Names:

HP_0189

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP MF_00143.
Sequence similarities	Belongs to the UPF0114 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	UPF0114 protein HP_0189 HAMAP MF_00143		PRO_0000214371
Regions
	Transmembrane	15 – 35	21	Helical; Potential
	Transmembrane	54 – 74	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O24989 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 782125BD0BA303DD	FASTA	177	19,828
	10 20 30 40 50 60 MLEKLIERVL FATRWLLAPL CIAMSLVLVV LGYVFMKELW HMLSHLNTIS ETDLVLSALG 70 80 90 100 110 120 LVDLLFMAGL VLMVLLASYE SFVSKLDKVD ASEITWLKHT DFNALKLKVS LSIVAISAIF 130 140 150 160 170 LLKRYMSLED VLSSIPKDTP LSHNPIFWQV VIHLVFVCSA LLAAVTNNIA FSQNKAH

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07256.1.
PIR	E64543.
RefSeq	NP_206988.1. NC_000915.1.
3D structure databases
ProteinModelPortal	O24989.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3137N.
MINT	MINT-176435.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	898953.
GenomeReviews	Gene locus HP_0189 in contig AE000511_GR.
KEGG	hpy:HP0189.
NMPDR	fig|85962.1.peg.186.
PATRIC	20591599. VBIHelPyl33062_0199.
TIGR	HP_0189.
Phylogenomic databases
HOGENOM	HBG474035.
OMA	MVIIGGY.
ProtClustDB	PRK05208.
Family and domain databases
HAMAP	MF_00143. UPF0114. [Tree]
InterPro	IPR005134. UPF0114. IPR020761. UPF0114_bac. IPR020765. UPF0114_gbac. [Graphical view]
Pfam	PF03350. UPF0114. 1 hit. [Graphical view]
TIGRFAMs	TIGR00645. HI0507. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Y189_HELPY

Accession

Primary (citable) accession number: O24989

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program