O24982 (LNT_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein N-acyltransferase
Short name=ALP N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lnt
Ordered Locus Names:	HP_0180

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the fatty acyl group on membrane lipoproteins By similarity. HAMAP MF_01148
Pathway	Protein modification; lipoprotein biosynthesis (N-acyl transfer). HAMAP MF_01148
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01148.
Sequence similarities	Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipoprotein biosynthetic process Inferred from electronic annotation. Source: InterPro nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acyltransferase activity Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Apolipoprotein N-acyltransferase HAMAP MF_01148		PRO_0000178071
Regions
	Transmembrane	5 – 27	23	Helical; Potential
	Transmembrane	37 – 54	18	Helical; Potential
	Transmembrane	61 – 78	18	Helical; Potential
	Transmembrane	88 – 110	23	Helical; Potential
	Transmembrane	117 – 135	19	Helical; Potential
	Transmembrane	150 – 167	18	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O24982 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2287520B14B48BBE	FASTA	425	48,474
	10 20 30 40 50 60 MRLLLFNQNA FLLACMFVSS VYVNAVLDAY AIENPYISIT LTSLLAPLSM LAFLKTPRNS 70 80 90 100 110 120 AFALGFFVGA LLFYWCALSF RYSDFTYLLP LIIVLIALVY GVLFYLLLYF ENPYFRLLSF 130 140 150 160 170 180 LGSSFIHPFG FDWLVPDSFF SYSVFRVDKL SLGLVFLACI FLSTKPLKKY RIIGVLLLLG 190 200 210 220 230 240 ALDFNGFKTS DLKKVGNIEL VSTKTPQDLK FDSSYLNDIE NNILKEIKLA QSKQKTLIVF 250 260 270 280 290 300 PETAYPIALE NSPFKAKLED LSDNIAILIG TLRTQGYNLY NSSFLFSKES VQIADKVILA 310 320 330 340 350 360 PFGETMPLPE FLQKPLEKLF FGESTYLYRN APHFSDFTLD DFTFRPLICY EGTSKPAYSN 370 380 390 400 410 420 SPSKIFIVMS NNAWFSPSIE PTLQRTLLKY YARRYDKIIL HSANFSTSYI LSPSLLGDIL FRKRS

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07250.1.
PIR	D64542.
RefSeq	NP_206979.1. NC_000915.1.
3D structure databases
ProteinModelPortal	O24982.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	900142.
GenomeReviews	Gene locus HP_0180 in contig AE000511_GR.
KEGG	hpy:HP0180.
NMPDR	fig|85962.1.peg.177.
PATRIC	20591583. VBIHelPyl33062_0191.
TIGR	HP_0180.
Phylogenomic databases
HOGENOM	HBG393025.
OMA	AICYEAT.
ProtClustDB	PRK12291.
Family and domain databases
HAMAP	MF_01148. Lnt. [Tree]
InterPro	IPR004563. Apolipo_AcylTrfase. IPR003010. Ntlse/CNhydtse. [Graphical view]
Gene3D	G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
KO	K03820.
Pfam	PF00795. CN_hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56317. Ntlse/CNhydtse. 1 hit.
TIGRFAMs	TIGR00546. Lnt. 1 hit.
PROSITE	PS50263. CN_HYDROLASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LNT_HELPY

Accession

Primary (citable) accession number: O24982

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program