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Protein

Putative beta-lactamase HcpD

Gene

hcpD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives (By similarity). Binds to penicillin.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP0160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpD (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name:
PBP 4
Gene namesi
Name:hcpD
Ordered Locus Names:HP_0160
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25PROSITE-ProRule annotationAdd BLAST25
ChainiPRO_000001319826 – 306Putative beta-lactamase HcpDAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 63Sequence analysis
Disulfide bondi91 ↔ 99Sequence analysis
Disulfide bondi127 ↔ 135Sequence analysis
Disulfide bondi163 ↔ 171Sequence analysis
Disulfide bondi199 ↔ 207Sequence analysis
Disulfide bondi235 ↔ 243Sequence analysis
Disulfide bondi271 ↔ 279Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO24968
PRIDEiO24968

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0160

Structurei

3D structure databases

ProteinModelPortaliO24968
SMRiO24968
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 61TPR 1Add BLAST34
Repeati96 – 133TPR 2Add BLAST38
Repeati168 – 205TPR 3Add BLAST38
Repeati240 – 277TPR 4Add BLAST38

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiENOG4105EUU Bacteria
COG0790 LUCA
KOiK07126
OMAiGHKHEIG

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF08238 Sel1, 7 hits
SMARTiView protein in SMART
SM00671 SEL1, 7 hits
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSWTKKWF LILFLMASCS SYLVATTGEK YFKMATQAFK RGDYHKAVAF
60 70 80 90 100
YKRSCNLRVG VGCTSLGSMY EDGDGVDQNI TKAVFYYRRG CNLRNHLACA
110 120 130 140 150
SLGSMYEDGD GVQKNLPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ
160 170 180 190 200
NYAKALFLSK YACSLNYGIS CNFVGYMYRN AKGVQKDLKK ALANFKRGCH
210 220 230 240 250
LKDGASCVSL GYMYEVGMDV KQNGEQALNL YKKGCYLKRG SGCHNVAVMY
260 270 280 290 300
YTGKGVPKDL DKAISYYKKG CTLGFSGSCK VLEEVIGKKS DDLQDDAQND

TQDDMQ
Length:306
Mass (Da):34,097
Last modified:January 1, 1998 - v1
Checksum:iD3BDE25CA3009B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07230.1
PIRiH64539
RefSeqiNP_206959.1, NC_000915.1
WP_000597856.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07230; AAD07230; HP_0160
GeneIDi900146
KEGGiheo:C694_00800
hpy:HP0160
PATRICifig|85962.47.peg.173

Similar proteinsi

Entry informationi

Entry nameiHCPD_HELPY
AccessioniPrimary (citable) accession number: O24968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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