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O24968

- HCPD_HELPY

UniProt

O24968 - HCPD_HELPY

Protein

Putative beta-lactamase HcpD

Gene

hcpD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity. Binds to penicillin.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPY:HP0160-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-lactamase HcpD (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein D
    Penicillin-binding protein 4
    Short name:
    PBP 4
    Gene namesi
    Name:hcpD
    Ordered Locus Names:HP_0160
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525PROSITE-ProRule annotationAdd
    BLAST
    Chaini26 – 306281Putative beta-lactamase HcpDPRO_0000013198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 63Sequence Analysis
    Disulfide bondi91 ↔ 99Sequence Analysis
    Disulfide bondi127 ↔ 135Sequence Analysis
    Disulfide bondi163 ↔ 171Sequence Analysis
    Disulfide bondi199 ↔ 207Sequence Analysis
    Disulfide bondi235 ↔ 243Sequence Analysis
    Disulfide bondi271 ↔ 279Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO24968.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0160.

    Structurei

    3D structure databases

    ProteinModelPortaliO24968.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 6134TPR 1Add
    BLAST
    Repeati96 – 13338TPR 2Add
    BLAST
    Repeati168 – 20538TPR 3Add
    BLAST
    Repeati240 – 27738TPR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiMYEDGDG.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF08238. Sel1. 7 hits.
    [Graphical view]
    SMARTiSM00671. SEL1. 7 hits.
    [Graphical view]
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O24968-1 [UniParc]FASTAAdd to Basket

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    MIKSWTKKWF LILFLMASCS SYLVATTGEK YFKMATQAFK RGDYHKAVAF    50
    YKRSCNLRVG VGCTSLGSMY EDGDGVDQNI TKAVFYYRRG CNLRNHLACA 100
    SLGSMYEDGD GVQKNLPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ 150
    NYAKALFLSK YACSLNYGIS CNFVGYMYRN AKGVQKDLKK ALANFKRGCH 200
    LKDGASCVSL GYMYEVGMDV KQNGEQALNL YKKGCYLKRG SGCHNVAVMY 250
    YTGKGVPKDL DKAISYYKKG CTLGFSGSCK VLEEVIGKKS DDLQDDAQND 300
    TQDDMQ 306
    Length:306
    Mass (Da):34,097
    Last modified:January 1, 1998 - v1
    Checksum:iD3BDE25CA3009B87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07230.1.
    PIRiH64539.
    RefSeqiNP_206959.1. NC_000915.1.
    YP_006934084.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07230; AAD07230; HP_0160.
    GeneIDi13869340.
    900146.
    KEGGiheo:C694_00800.
    hpy:HP0160.
    PATRICi20591541. VBIHelPyl33062_0170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07230.1 .
    PIRi H64539.
    RefSeqi NP_206959.1. NC_000915.1.
    YP_006934084.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O24968.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0160.

    Proteomic databases

    PRIDEi O24968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07230 ; AAD07230 ; HP_0160 .
    GeneIDi 13869340.
    900146.
    KEGGi heo:C694_00800.
    hpy:HP0160.
    PATRICi 20591541. VBIHelPyl33062_0170.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi MYEDGDG.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPY:HP0160-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF08238. Sel1. 7 hits.
    [Graphical view ]
    SMARTi SM00671. SEL1. 7 hits.
    [Graphical view ]
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Identification of a novel penicillin-binding protein from Helicobacter pylori."
      Krishnamurthy P., Parlow M.H., Schneider J., Burroughs S., Wickland C., Vakil N.B., Dunn B.E., Phadnis S.H.
      J. Bacteriol. 181:5107-5110(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PENICILLIN-BINDING.

    Entry informationi

    Entry nameiHCPD_HELPY
    AccessioniPrimary (citable) accession number: O24968
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3