Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O24968 (HCPD_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpD

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name=PBP 4
Gene names
Name:hcpD
Ordered Locus Names:HP_0160
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity. Binds to penicillin.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 4 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 306281Putative beta-lactamase HcpD
PRO_0000013198

Regions

Repeat28 – 6134TPR 1
Repeat96 – 13338TPR 2
Repeat168 – 20538TPR 3
Repeat240 – 27738TPR 4

Amino acid modifications

Disulfide bond55 ↔ 63 Potential
Disulfide bond91 ↔ 99 Potential
Disulfide bond127 ↔ 135 Potential
Disulfide bond163 ↔ 171 Potential
Disulfide bond199 ↔ 207 Potential
Disulfide bond235 ↔ 243 Potential
Disulfide bond271 ↔ 279 Potential

Sequences

Sequence LengthMass (Da)Tools
O24968 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D3BDE25CA3009B87

FASTA30634,097
        10         20         30         40         50         60 
MIKSWTKKWF LILFLMASCS SYLVATTGEK YFKMATQAFK RGDYHKAVAF YKRSCNLRVG 

        70         80         90        100        110        120 
VGCTSLGSMY EDGDGVDQNI TKAVFYYRRG CNLRNHLACA SLGSMYEDGD GVQKNLPKAI 

       130        140        150        160        170        180 
YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ NYAKALFLSK YACSLNYGIS CNFVGYMYRN 

       190        200        210        220        230        240 
AKGVQKDLKK ALANFKRGCH LKDGASCVSL GYMYEVGMDV KQNGEQALNL YKKGCYLKRG 

       250        260        270        280        290        300 
SGCHNVAVMY YTGKGVPKDL DKAISYYKKG CTLGFSGSCK VLEEVIGKKS DDLQDDAQND 


TQDDMQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07230.1.
PIRH64539.
RefSeqNP_206959.1. NC_000915.1.
YP_006934084.1. NC_018939.1.

3D structure databases

ProteinModelPortalO24968.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0160.

Proteomic databases

PRIDEO24968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07230; AAD07230; HP_0160.
GeneID900146.
KEGGheo:C694_00800.
hpy:HP0160.
PATRIC20591541. VBIHelPyl33062_0170.

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAMYEDGDG.
OrthoDBEOG6TJ7WZ.

Enzyme and pathway databases

BioCycHPY:HP0160-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF08238. Sel1. 7 hits.
[Graphical view]
SMARTSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPD_HELPY
AccessionPrimary (citable) accession number: O24968
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names