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O24968

- HCPD_HELPY

UniProt

O24968 - HCPD_HELPY

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Protein

Putative beta-lactamase HcpD

Gene

hcpD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity. Binds to penicillin.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPY:HP0160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpD (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name:
PBP 4
Gene namesi
Name:hcpD
Ordered Locus Names:HP_0160
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525PROSITE-ProRule annotationAdd
BLAST
Chaini26 – 306281Putative beta-lactamase HcpDPRO_0000013198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 63Sequence Analysis
Disulfide bondi91 ↔ 99Sequence Analysis
Disulfide bondi127 ↔ 135Sequence Analysis
Disulfide bondi163 ↔ 171Sequence Analysis
Disulfide bondi199 ↔ 207Sequence Analysis
Disulfide bondi235 ↔ 243Sequence Analysis
Disulfide bondi271 ↔ 279Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO24968.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0160.

Structurei

3D structure databases

ProteinModelPortaliO24968.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6134TPR 1Add
BLAST
Repeati96 – 13338TPR 2Add
BLAST
Repeati168 – 20538TPR 3Add
BLAST
Repeati240 – 27738TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiMYEDGDG.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24968-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKSWTKKWF LILFLMASCS SYLVATTGEK YFKMATQAFK RGDYHKAVAF
60 70 80 90 100
YKRSCNLRVG VGCTSLGSMY EDGDGVDQNI TKAVFYYRRG CNLRNHLACA
110 120 130 140 150
SLGSMYEDGD GVQKNLPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ
160 170 180 190 200
NYAKALFLSK YACSLNYGIS CNFVGYMYRN AKGVQKDLKK ALANFKRGCH
210 220 230 240 250
LKDGASCVSL GYMYEVGMDV KQNGEQALNL YKKGCYLKRG SGCHNVAVMY
260 270 280 290 300
YTGKGVPKDL DKAISYYKKG CTLGFSGSCK VLEEVIGKKS DDLQDDAQND

TQDDMQ
Length:306
Mass (Da):34,097
Last modified:January 1, 1998 - v1
Checksum:iD3BDE25CA3009B87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07230.1.
PIRiH64539.
RefSeqiNP_206959.1. NC_000915.1.
YP_006934084.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07230; AAD07230; HP_0160.
GeneIDi13869340.
900146.
KEGGiheo:C694_00800.
hpy:HP0160.
PATRICi20591541. VBIHelPyl33062_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07230.1 .
PIRi H64539.
RefSeqi NP_206959.1. NC_000915.1.
YP_006934084.1. NC_018939.1.

3D structure databases

ProteinModelPortali O24968.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0160.

Proteomic databases

PRIDEi O24968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07230 ; AAD07230 ; HP_0160 .
GeneIDi 13869340.
900146.
KEGGi heo:C694_00800.
hpy:HP0160.
PATRICi 20591541. VBIHelPyl33062_0170.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi MYEDGDG.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPY:HP0160-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF08238. Sel1. 7 hits.
[Graphical view ]
SMARTi SM00671. SEL1. 7 hits.
[Graphical view ]
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Identification of a novel penicillin-binding protein from Helicobacter pylori."
    Krishnamurthy P., Parlow M.H., Schneider J., Burroughs S., Wickland C., Vakil N.B., Dunn B.E., Phadnis S.H.
    J. Bacteriol. 181:5107-5110(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PENICILLIN-BINDING.

Entry informationi

Entry nameiHCPD_HELPY
AccessioniPrimary (citable) accession number: O24968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3