O24958 (CCOP_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cbb3-type cytochrome c oxidase subunit CcoP
Short name=Cbb3-Cox subunit CcoP

Alternative name(s):
C-type cytochrome CcoP
Short name=Cyt c(P)
Cytochrome c oxidase subunit III

Gene names

Name:	ccoP
Ordered Locus Names:	HP_0147

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump By similarity.
Cofactor	Binds 2 heme C groups per subunit By similarity.
Pathway	Energy metabolism; oxidative phosphorylation.
Subunit structure	Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CcoP / FixP family. Contains 2 cytochrome c domains.

Ontologies

Keywords
Biological process	Electron transport Hydrogen ion transport Ion transport Respiratory chain Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Cbb3-type cytochrome c oxidase subunit CcoP		PRO_0000412285
Regions
	Transmembrane	11 – 31	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Domain	116 – 195	80	Cytochrome c 1
	Domain	205 – 286	82	Cytochrome c 2
Sites
	Metal binding	133	1	Iron (heme C 1 axial ligand) By similarity
	Metal binding	174	1	Iron (heme C 2 axial ligand) By similarity
	Metal binding	223	1	Iron (heme C 2 axial ligand) By similarity
	Metal binding	264	1	Iron (heme C 1 axial ligand) By similarity
	Binding site	129	1	Heme C 1 (covalent) By similarity
	Binding site	132	1	Heme C 1 (covalent) By similarity
	Binding site	219	1	Heme C 2 (covalent) By similarity
	Binding site	222	1	Heme C 2 (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O24958 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 91C569BC60C1D602	FASTA	286	31,866
	10 20 30 40 50 60 MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI DGIGEFANNV 70 80 90 100 110 120 PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA HNQKFEAKWK HLGQKELVDM 130 140 150 160 170 180 GQGIFLVHCS QCHGITAEGL HGSAQNLVRW GKEEGIMDTI KHGSKGMDYL AGEMPAMELD 190 200 210 220 230 240 EKDAKAIASY VMAELSSVKK TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL 250 260 270 280 TAYGTENFLR NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07216.1.
PIR	C64538.
RefSeq	NP_206946.1. NC_000915.1. YP_006934070.1. NC_018939.1.
3D structure databases
HSSP	HSSP built from PDB template 2PCB based on UniProtKB P00004.
ProteinModelPortal	O24958.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP0147.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07216; AAD07216; HP_0147.
GeneID	13869326. 899135.
KEGG	heo:C694_00730. hpy:HP0147.
PATRIC	20591513. VBIHelPyl33062_0156.
Phylogenomic databases
KO	K00406.
OMA	AKWKNLG.
ProtClustDB	CLSK872282.
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
InterPro	IPR009056. Cyt_c_dom. IPR004678. Cyt_c_oxidase_cbb3_su3. [Graphical view]
PIRSF	PIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAM	SSF46626. Cytochrome_c. 2 hits.
TIGRFAMs	TIGR00782. ccoP. 1 hit.
PROSITE	PS51007. CYTC. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCOP_HELPY

Accession

Primary (citable) accession number: O24958

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program