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O24958

- CCOP_HELPY

UniProt

O24958 - CCOP_HELPY

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Protein
Cbb3-type cytochrome c oxidase subunit CcoP
Gene
ccoP, HP_0147
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump By similarity.

Cofactori

Binds 2 heme C groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291Heme C 1 (covalent) By similarity
Binding sitei132 – 1321Heme C 1 (covalent) By similarity
Metal bindingi133 – 1331Iron (heme C 1 axial ligand) By similarity
Metal bindingi174 – 1741Iron (heme C 2 axial ligand) By similarity
Binding sitei219 – 2191Heme C 2 (covalent) By similarity
Binding sitei222 – 2221Heme C 2 (covalent) By similarity
Metal bindingi223 – 2231Iron (heme C 2 axial ligand) By similarity
Metal bindingi264 – 2641Iron (heme C 1 axial ligand) By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. oxidative phosphorylation Source: UniProtKB-UniPathway
  2. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit CcoP
Short name:
Cbb3-Cox subunit CcoP
Alternative name(s):
C-type cytochrome CcoP
Short name:
Cyt c(P)
Cytochrome c oxidase subunit III
Gene namesi
Name:ccoP
Ordered Locus Names:HP_0147
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Cbb3-type cytochrome c oxidase subunit CcoP
PRO_0000412285Add
BLAST

Proteomic databases

PRIDEiO24958.

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP By similarity.

Protein-protein interaction databases

STRINGi85962.HP0147.

Structurei

3D structure databases

ProteinModelPortaliO24958.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 19580Cytochrome c 1
Add
BLAST
Domaini205 – 28682Cytochrome c 2
Add
BLAST

Sequence similaritiesi

Belongs to the CcoP / FixP family.
Contains 2 cytochrome c domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00406.
OMAiAKWKNLG.
OrthoDBiEOG6H4K86.

Family and domain databases

Gene3Di1.10.760.10. 2 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24958-1 [UniParc]FASTAAdd to Basket

« Hide

MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI    50
DGIGEFANNV PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA 100
HNQKFEAKWK HLGQKELVDM GQGIFLVHCS QCHGITAEGL HGSAQNLVRW 150
GKEEGIMDTI KHGSKGMDYL AGEMPAMELD EKDAKAIASY VMAELSSVKK 200
TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL TAYGTENFLR 250
NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR 286
Length:286
Mass (Da):31,866
Last modified:January 1, 1998 - v1
Checksum:i91C569BC60C1D602
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07216.1.
PIRiC64538.
RefSeqiNP_206946.1. NC_000915.1.
YP_006934070.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07216; AAD07216; HP_0147.
GeneIDi13869326.
899135.
KEGGiheo:C694_00730.
hpy:HP0147.
PATRICi20591513. VBIHelPyl33062_0156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07216.1 .
PIRi C64538.
RefSeqi NP_206946.1. NC_000915.1.
YP_006934070.1. NC_018939.1.

3D structure databases

ProteinModelPortali O24958.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85962.HP0147.

Proteomic databases

PRIDEi O24958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07216 ; AAD07216 ; HP_0147 .
GeneIDi 13869326.
899135.
KEGGi heo:C694_00730.
hpy:HP0147.
PATRICi 20591513. VBIHelPyl33062_0156.

Phylogenomic databases

KOi K00406.
OMAi AKWKNLG.
OrthoDBi EOG6H4K86.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.10.760.10. 2 hits.
InterProi IPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view ]
Pfami PF13442. Cytochrome_CBB3. 2 hits.
[Graphical view ]
PIRSFi PIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMi SSF46626. SSF46626. 2 hits.
TIGRFAMsi TIGR00782. ccoP. 1 hit.
PROSITEi PS51007. CYTC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCCOP_HELPY
AccessioniPrimary (citable) accession number: O24958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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