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O24958 (CCOP_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cbb3-type cytochrome c oxidase subunit CcoP

Short name=Cbb3-Cox subunit CcoP
Alternative name(s):
C-type cytochrome CcoP
Short name=Cyt c(P)
Cytochrome c oxidase subunit III
Gene names
Name:ccoP
Ordered Locus Names:HP_0147
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump By similarity.

Cofactor

Binds 2 heme C groups per subunit By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subunit structure

Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CcoP / FixP family.

Contains 2 cytochrome c domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Cbb3-type cytochrome c oxidase subunit CcoP
PRO_0000412285

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane62 – 8221Helical; Potential
Domain116 – 19580Cytochrome c 1
Domain205 – 28682Cytochrome c 2

Sites

Metal binding1331Iron (heme C 1 axial ligand) By similarity
Metal binding1741Iron (heme C 2 axial ligand) By similarity
Metal binding2231Iron (heme C 2 axial ligand) By similarity
Metal binding2641Iron (heme C 1 axial ligand) By similarity
Binding site1291Heme C 1 (covalent) By similarity
Binding site1321Heme C 1 (covalent) By similarity
Binding site2191Heme C 2 (covalent) By similarity
Binding site2221Heme C 2 (covalent) By similarity

Sequences

Sequence LengthMass (Da)Tools
O24958 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 91C569BC60C1D602

FASTA28631,866
        10         20         30         40         50         60 
MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI DGIGEFANNV 

        70         80         90        100        110        120 
PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA HNQKFEAKWK HLGQKELVDM 

       130        140        150        160        170        180 
GQGIFLVHCS QCHGITAEGL HGSAQNLVRW GKEEGIMDTI KHGSKGMDYL AGEMPAMELD 

       190        200        210        220        230        240 
EKDAKAIASY VMAELSSVKK TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL 

       250        260        270        280 
TAYGTENFLR NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07216.1.
PIRC64538.
RefSeqNP_206946.1. NC_000915.1.
YP_006934070.1. NC_018939.1.

3D structure databases

ProteinModelPortalO24958.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0147.

Proteomic databases

PRIDEO24958.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07216; AAD07216; HP_0147.
GeneID899135.
KEGGheo:C694_00730.
hpy:HP0147.
PATRIC20591513. VBIHelPyl33062_0156.

Phylogenomic databases

KOK00406.
OMAAKWKNLG.
OrthoDBEOG6H4K86.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.10.760.10. 2 hits.
InterProIPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamPF13442. Cytochrome_CBB3. 2 hits.
[Graphical view]
PIRSFPIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMSSF46626. SSF46626. 2 hits.
TIGRFAMsTIGR00782. ccoP. 1 hit.
PROSITEPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCOP_HELPY
AccessionPrimary (citable) accession number: O24958
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names