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O24958

- CCOP_HELPY

UniProt

O24958 - CCOP_HELPY

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Protein

Cbb3-type cytochrome c oxidase subunit CcoP

Gene

ccoP

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291Heme C 1 (covalent)By similarity
Binding sitei132 – 1321Heme C 1 (covalent)By similarity
Metal bindingi133 – 1331Iron (heme C 1 axial ligand)By similarity
Metal bindingi174 – 1741Iron (heme C 2 axial ligand)By similarity
Binding sitei219 – 2191Heme C 2 (covalent)By similarity
Binding sitei222 – 2221Heme C 2 (covalent)By similarity
Metal bindingi223 – 2231Iron (heme C 2 axial ligand)By similarity
Metal bindingi264 – 2641Iron (heme C 1 axial ligand)By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. oxidative phosphorylation Source: UniProtKB-UniPathway
  2. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit CcoPBy similarity
Short name:
Cbb3-Cox subunit CcoPBy similarity
Alternative name(s):
C-type cytochrome CcoPBy similarity
Short name:
Cyt c(P)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:ccoPBy similarity
Ordered Locus Names:HP_0147
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cell inner membrane By similaritySequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Cbb3-type cytochrome c oxidase subunit CcoPPRO_0000412285Add
BLAST

Proteomic databases

PRIDEiO24958.

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP.By similarity

Protein-protein interaction databases

STRINGi85962.HP0147.

Structurei

3D structure databases

ProteinModelPortaliO24958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 19580Cytochrome c 1PROSITE-ProRule annotationAdd
BLAST
Domaini205 – 28682Cytochrome c 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated
Contains 2 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00406.
OMAiAKWKNLG.
OrthoDBiEOG6H4K86.

Family and domain databases

Gene3Di1.10.760.10. 2 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24958-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI
60 70 80 90 100
DGIGEFANNV PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA
110 120 130 140 150
HNQKFEAKWK HLGQKELVDM GQGIFLVHCS QCHGITAEGL HGSAQNLVRW
160 170 180 190 200
GKEEGIMDTI KHGSKGMDYL AGEMPAMELD EKDAKAIASY VMAELSSVKK
210 220 230 240 250
TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL TAYGTENFLR
260 270 280
NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR
Length:286
Mass (Da):31,866
Last modified:January 1, 1998 - v1
Checksum:i91C569BC60C1D602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07216.1.
PIRiC64538.
RefSeqiNP_206946.1. NC_000915.1.
YP_006934070.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07216; AAD07216; HP_0147.
GeneIDi13869326.
899135.
KEGGiheo:C694_00730.
hpy:HP0147.
PATRICi20591513. VBIHelPyl33062_0156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07216.1 .
PIRi C64538.
RefSeqi NP_206946.1. NC_000915.1.
YP_006934070.1. NC_018939.1.

3D structure databases

ProteinModelPortali O24958.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0147.

Proteomic databases

PRIDEi O24958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07216 ; AAD07216 ; HP_0147 .
GeneIDi 13869326.
899135.
KEGGi heo:C694_00730.
hpy:HP0147.
PATRICi 20591513. VBIHelPyl33062_0156.

Phylogenomic databases

KOi K00406.
OMAi AKWKNLG.
OrthoDBi EOG6H4K86.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.10.760.10. 2 hits.
InterProi IPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view ]
Pfami PF13442. Cytochrome_CBB3. 2 hits.
[Graphical view ]
PIRSFi PIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMi SSF46626. SSF46626. 2 hits.
TIGRFAMsi TIGR00782. ccoP. 1 hit.
PROSITEi PS51007. CYTC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCCOP_HELPY
AccessioniPrimary (citable) accession number: O24958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3