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Protein

Cbb3-type cytochrome c oxidase subunit CcoP

Gene

ccoP

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei129Heme C 1 (covalent)By similarity1
Binding sitei132Heme C 1 (covalent)By similarity1
Metal bindingi133Iron (heme C 1 axial ligand)By similarity1
Metal bindingi174Iron (heme C 2 axial ligand)By similarity1
Binding sitei219Heme C 2 (covalent)By similarity1
Binding sitei222Heme C 2 (covalent)By similarity1
Metal bindingi223Iron (heme C 2 axial ligand)By similarity1
Metal bindingi264Iron (heme C 1 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit CcoPBy similarity
Short name:
Cbb3-Cox subunit CcoPBy similarity
Alternative name(s):
C-type cytochrome CcoPBy similarity
Short name:
Cyt c(P)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:ccoPBy similarity
Ordered Locus Names:HP_0147
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane Sequence analysisBy similarity; Multi-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122851 – 286Cbb3-type cytochrome c oxidase subunit CcoPAdd BLAST286

Proteomic databases

PaxDbiO24958
PRIDEiO24958

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP.By similarity

Protein-protein interaction databases

STRINGi85962.HP0147

Structurei

3D structure databases

ProteinModelPortaliO24958
SMRiO24958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 195Cytochrome c 1PROSITE-ProRule annotationAdd BLAST80
Domaini205 – 286Cytochrome c 2PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107UIK Bacteria
COG2010 LUCA
KOiK00406
OMAiENWDGIG

Family and domain databases

Gene3Di1.10.760.10, 2 hits
1.20.58.1490, 1 hit
InterProiView protein in InterPro
IPR032858 CcoP_N
IPR038414 CcoP_N_sf
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR004678 Cyt_c_oxidase_cbb3_su3
PfamiView protein in Pfam
PF13442 Cytochrome_CBB3, 2 hits
PF14715 FixP_N, 1 hit
PIRSFiPIRSF000006 Cbb3-Cox_fixP, 1 hit
SUPFAMiSSF46626 SSF46626, 2 hits
TIGRFAMsiTIGR00782 ccoP, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 2 hits

Sequencei

Sequence statusi: Complete.

O24958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI
60 70 80 90 100
DGIGEFANNV PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA
110 120 130 140 150
HNQKFEAKWK HLGQKELVDM GQGIFLVHCS QCHGITAEGL HGSAQNLVRW
160 170 180 190 200
GKEEGIMDTI KHGSKGMDYL AGEMPAMELD EKDAKAIASY VMAELSSVKK
210 220 230 240 250
TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL TAYGTENFLR
260 270 280
NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR
Length:286
Mass (Da):31,866
Last modified:January 1, 1998 - v1
Checksum:i91C569BC60C1D602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07216.1
PIRiC64538
RefSeqiNP_206946.1, NC_000915.1
WP_010875445.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07216; AAD07216; HP_0147
GeneIDi899135
KEGGiheo:C694_00730
hpy:HP0147
PATRICifig|85962.47.peg.159

Similar proteinsi

Entry informationi

Entry nameiCCOP_HELPY
AccessioniPrimary (citable) accession number: O24958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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