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O24958

- CCOP_HELPY

UniProt

O24958 - CCOP_HELPY

Protein

Cbb3-type cytochrome c oxidase subunit CcoP

Gene

ccoP

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump By similarity.By similarity

    Cofactori

    Binds 2 heme C groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei129 – 1291Heme C 1 (covalent)By similarity
    Binding sitei132 – 1321Heme C 1 (covalent)By similarity
    Metal bindingi133 – 1331Iron (heme C 1 axial ligand)By similarity
    Metal bindingi174 – 1741Iron (heme C 2 axial ligand)By similarity
    Binding sitei219 – 2191Heme C 2 (covalent)By similarity
    Binding sitei222 – 2221Heme C 2 (covalent)By similarity
    Metal bindingi223 – 2231Iron (heme C 2 axial ligand)By similarity
    Metal bindingi264 – 2641Iron (heme C 1 axial ligand)By similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. oxidative phosphorylation Source: UniProtKB-UniPathway
    2. proton transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cbb3-type cytochrome c oxidase subunit CcoPBy similarity
    Short name:
    Cbb3-Cox subunit CcoPBy similarity
    Alternative name(s):
    C-type cytochrome CcoPBy similarity
    Short name:
    Cyt c(P)By similarity
    Cytochrome c oxidase subunit IIIBy similarity
    Gene namesi
    Name:ccoPBy similarity
    Ordered Locus Names:HP_0147
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cell inner membrane By similaritySequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Cbb3-type cytochrome c oxidase subunit CcoPPRO_0000412285Add
    BLAST

    Proteomic databases

    PRIDEiO24958.

    Interactioni

    Subunit structurei

    Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP0147.

    Structurei

    3D structure databases

    ProteinModelPortaliO24958.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini116 – 19580Cytochrome c 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 28682Cytochrome c 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CcoP / FixP family.Curated
    Contains 2 cytochrome c domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK00406.
    OMAiAKWKNLG.
    OrthoDBiEOG6H4K86.

    Family and domain databases

    Gene3Di1.10.760.10. 2 hits.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR004678. Cyt_c_oxidase_cbb3_su3.
    [Graphical view]
    PfamiPF13442. Cytochrome_CBB3. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
    SUPFAMiSSF46626. SSF46626. 2 hits.
    TIGRFAMsiTIGR00782. ccoP. 1 hit.
    PROSITEiPS51007. CYTC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O24958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLNDHINV FGLIAALVIL VLTIYESSSL IKEMRDSKSQ GELVENGHLI    50
    DGIGEFANNV PVGWIASFMC TIVWAFWYFF FGYPLNSFSQ IGQYNEEVKA 100
    HNQKFEAKWK HLGQKELVDM GQGIFLVHCS QCHGITAEGL HGSAQNLVRW 150
    GKEEGIMDTI KHGSKGMDYL AGEMPAMELD EKDAKAIASY VMAELSSVKK 200
    TKNPQLIDKG KELFESMGCT GCHGNDGKGL QENQVFAADL TAYGTENFLR 250
    NILTHGKKGN IGHMPSFKYK NFSDLQVKAL LNLSNR 286
    Length:286
    Mass (Da):31,866
    Last modified:January 1, 1998 - v1
    Checksum:i91C569BC60C1D602
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07216.1.
    PIRiC64538.
    RefSeqiNP_206946.1. NC_000915.1.
    YP_006934070.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07216; AAD07216; HP_0147.
    GeneIDi13869326.
    899135.
    KEGGiheo:C694_00730.
    hpy:HP0147.
    PATRICi20591513. VBIHelPyl33062_0156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07216.1 .
    PIRi C64538.
    RefSeqi NP_206946.1. NC_000915.1.
    YP_006934070.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O24958.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0147.

    Proteomic databases

    PRIDEi O24958.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07216 ; AAD07216 ; HP_0147 .
    GeneIDi 13869326.
    899135.
    KEGGi heo:C694_00730.
    hpy:HP0147.
    PATRICi 20591513. VBIHelPyl33062_0156.

    Phylogenomic databases

    KOi K00406.
    OMAi AKWKNLG.
    OrthoDBi EOG6H4K86.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.10.760.10. 2 hits.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR004678. Cyt_c_oxidase_cbb3_su3.
    [Graphical view ]
    Pfami PF13442. Cytochrome_CBB3. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000006. Cbb3-Cox_fixP. 1 hit.
    SUPFAMi SSF46626. SSF46626. 2 hits.
    TIGRFAMsi TIGR00782. ccoP. 1 hit.
    PROSITEi PS51007. CYTC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiCCOP_HELPY
    AccessioniPrimary (citable) accession number: O24958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3