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O24931

- LUXS_HELPY

UniProt

O24931 - LUXS_HELPY

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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity).By similarity

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

Cofactori

Binds 1 iron ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581IronBy similarity
Metal bindingi62 – 621IronBy similarity
Metal bindingi125 – 1251IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:HP_0105
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155S-ribosylhomocysteine lyasePRO_0000172229Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3186N.
IntActiO24931. 1 interaction.
MINTiMINT-173545.
STRINGi85962.HP0105.

Structurei

3D structure databases

ProteinModelPortaliO24931.
SMRiO24931. Positions 5-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.Curated

Phylogenomic databases

eggNOGiCOG1854.
KOiK07173.
OMAiFIAYEAT.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

O24931 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPKMNVES FNLDHTKVKA PYVRVADRKK GVNGDLIVKY DVRFKQPNQD
60 70 80 90 100
HMDMPSLHSL EHLVAEIIRN HASYVVDWSP MGCQTGFYLT VLNHDNYTEI
110 120 130 140 150
LEVLEKTMQD VLKATEVPAS NEKQCGWAAN HTLEGAKDLA RAFLDKRAEW

SEVGV
Length:155
Mass (Da):17,655
Last modified:January 1, 1998 - v1
Checksum:iA127A9FDBF109E0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07175.1.
PIRiA64533.
RefSeqiYP_006934028.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07175; AAD07175; HP_0105.
GeneIDi13869284.
KEGGiheo:C694_00520.
PATRICi20591425. VBIHelPyl33062_0112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07175.1 .
PIRi A64533.
RefSeqi YP_006934028.1. NC_018939.1.

3D structure databases

ProteinModelPortali O24931.
SMRi O24931. Positions 5-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3186N.
IntActi O24931. 1 interaction.
MINTi MINT-173545.
STRINGi 85962.HP0105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07175 ; AAD07175 ; HP_0105 .
GeneIDi 13869284.
KEGGi heo:C694_00520.
PATRICi 20591425. VBIHelPyl33062_0112.

Phylogenomic databases

eggNOGi COG1854.
KOi K07173.
OMAi FIAYEAT.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci HPY:HP0105-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiLUXS_HELPY
AccessioniPrimary (citable) accession number: O24931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3