ID   O24925_HELPY            Unreviewed;       675 AA.
AC   O24925;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   SubName: Full=Methyl-accepting chemotaxis protein (TlpA) {ECO:0000313|EMBL:AAD07167.1};
GN   OrderedLocusNames=HP_0099 {ECO:0000313|EMBL:AAD07167.1};
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07167.1, ECO:0000313|Proteomes:UP000000429};
RN   [1] {ECO:0000313|EMBL:AAD07167.1, ECO:0000313|Proteomes:UP000000429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA   Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA   Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA   Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA   Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA   Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE000511; AAD07167.1; -; Genomic_DNA.
DR   PIR; C64532; C64532.
DR   RefSeq; NP_206899.1; NC_000915.1.
DR   RefSeq; WP_000033553.1; NC_018939.1.
DR   AlphaFoldDB; O24925; -.
DR   SMR; O24925; -.
DR   DIP; DIP-3302N; -.
DR   IntAct; O24925; 3.
DR   MINT; O24925; -.
DR   STRING; 85962.HP_0099; -.
DR   PaxDb; 85962-C694_00485; -.
DR   EnsemblBacteria; AAD07167; AAD07167; HP_0099.
DR   KEGG; hpy:HP_0099; -.
DR   PATRIC; fig|85962.47.peg.105; -.
DR   eggNOG; COG0840; Bacteria.
DR   InParanoid; O24925; -.
DR   OrthoDB; 5348717at2; -.
DR   PhylomeDB; O24925; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF112; HEME-BASED AEROTACTIC TRANSDUCER HEMAT; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          475..675
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   COILED          586..641
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   675 AA;  74466 MW;  9AB7D470034B74A6 CRC64;
     MSKGLSIGNK IILCVALIVI VCVSILGVSL NSRVKEILKE SALHSMQDSL HFKVNEVQGV
     LENTYTSMGI VKEMLPKDTK REIKIGLLKN FILANSHVAG VSMFFKGRED LRLTLLRDNN
     TIKLVENPSL ENSPLAQKAM KNKEISKSLG YYRKMPNGAE VYGVDILLPL LNENAQEVVG
     ALMIFISIDS FSNEITKNRS DLFLIGTKGK VLLSANKSLQ DKPIAEIYKS VPKATNEVMA
     ILENGSKATL EYLDPFSHKE NFLAVETFKM LGKTESKDNL NWMIALIIEK DKVYEQVGSV
     RFVVIIASAI MVLALIIAIT LLMRAIVSSR LEAVSSTLSH FFKLLNNQAN SSGIKLIEAK
     SNDELGRMQT AINKNILQTQ KIMQEDRQAV QDTIKVVSDV KAGNFAVRIT AEPASPDLKE
     LRDALNGIMD YLQESVGTHM PSIFKIFESY SGLDFRGRIQ NASGRVELVT NALGQEIQKM
     LETSSNFAKD LANDSANLKE CVQNLEKASN SQHKSLMETS KTIENITTSI QGVSSQSEAM
     IEQGQDIKSI VEIIRDIADQ TNLLALNAAI EAARAGEHGR GFAVVADEVR KLAERTQKSL
     SEIEANINIL VQSISDTSES IKNQVKEVEE INASIEALRS VTEGNLKIAS DSLEISQEID
     KVSNDILEDV NKKQF
//