O24924 (THRC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Threonine synthase
Short name=TS
EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	HP_0098

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.
Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the threonine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Threonine synthase		PRO_0000185633
Amino acid modifications
	Modified residue	109	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O24924 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: CD9637799B508988	FASTA	486	54,707
	10 20 30 40 50 60 MPFVPTRSLK EKKIDFIEAI LNPNAPKGGL YTLERFETLQ WQDCLNLSYN DLVECVFERL 70 80 90 100 110 120 GLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL YHGPSLAFKD MALQPLASLF 130 140 150 160 170 180 SNLAVGKNEK YLMLVSTSGD TGPATLESLA GMPNVFVVCL YPKDGTSLVQ KLQMVTQSAS 190 200 210 220 230 240 NLKVFGISGD FDDAQNALKN LLKDDDFNEA LKACQLKLSV ANSVNFGRIA FQIVYHIWGF 250 260 270 280 290 300 LELYKKGAIN SKEKITLAIP SGNFGNALGA FYAKKMGLNI DKIKVVTNSN DVLREFIETG 310 320 330 340 350 360 RYDLTHRSLK QTYSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF YALKPKELAL 370 380 390 400 410 420 LQEHFSCASC SDEACLKTIQ EVYAEHQYLI DPHTATALNA SLKTHEKTLV SATASYEKFP 430 440 450 460 470 480 RITLLALNEQ KKNDNDKAAL ETLKNSYNTP DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLESLH

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07166.1.
PIR	B64532.
RefSeq	NP_206898.1. NC_000915.1. YP_006934020.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O24924.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP0098.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07166; AAD07166; HP_0098.
GeneID	13869276. 898925.
KEGG	heo:C694_00480. hpy:HP0098.
PATRIC	20591407. VBIHelPyl33062_0103.
Phylogenomic databases
eggNOG	COG0498.
KO	K01733.
OMA	FGRIAFQ.
ProtClustDB	PRK09225.
Enzyme and pathway databases
UniPathway	UPA00050; UER00065.
Family and domain databases
InterPro	IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase_like. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_HELPY

Accession

Primary (citable) accession number: O24924

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program