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O24924 (THRC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
Ordered Locus Names:HP_0098
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Threonine synthase
PRO_0000185633

Amino acid modifications

Modified residue1091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O24924 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CD9637799B508988

FASTA48654,707
        10         20         30         40         50         60 
MPFVPTRSLK EKKIDFIEAI LNPNAPKGGL YTLERFETLQ WQDCLNLSYN DLVECVFERL 

        70         80         90        100        110        120 
GLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL YHGPSLAFKD MALQPLASLF 

       130        140        150        160        170        180 
SNLAVGKNEK YLMLVSTSGD TGPATLESLA GMPNVFVVCL YPKDGTSLVQ KLQMVTQSAS 

       190        200        210        220        230        240 
NLKVFGISGD FDDAQNALKN LLKDDDFNEA LKACQLKLSV ANSVNFGRIA FQIVYHIWGF 

       250        260        270        280        290        300 
LELYKKGAIN SKEKITLAIP SGNFGNALGA FYAKKMGLNI DKIKVVTNSN DVLREFIETG 

       310        320        330        340        350        360 
RYDLTHRSLK QTYSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF YALKPKELAL 

       370        380        390        400        410        420 
LQEHFSCASC SDEACLKTIQ EVYAEHQYLI DPHTATALNA SLKTHEKTLV SATASYEKFP 

       430        440        450        460        470        480 
RITLLALNEQ KKNDNDKAAL ETLKNSYNTP DSQRLDDLFE RGIKHQEVLK LNEIKSSILL 


WLESLH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07166.1.
PIRB64532.
RefSeqNP_206898.1. NC_000915.1.
YP_006934020.1. NC_018939.1.

3D structure databases

ProteinModelPortalO24924.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0098.

Proteomic databases

PRIDEO24924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07166; AAD07166; HP_0098.
GeneID13869276.
898925.
KEGGheo:C694_00480.
hpy:HP0098.
PATRIC20591407. VBIHelPyl33062_0103.

Phylogenomic databases

eggNOGCOG0498.
KOK01733.
OMAPIFALNE.
OrthoDBEOG65BDJX.
ProtClustDBPRK09225.

Enzyme and pathway databases

BioCycHPY:HP0098-MONOMER.
UniPathwayUPA00050; UER00065.

Family and domain databases

InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_HELPY
AccessionPrimary (citable) accession number: O24924
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names