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O24924

- THRC_HELPY

UniProt

O24924 - THRC_HELPY

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Protein

Threonine synthase

Gene

thrC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPY:HP0098-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:HP_0098
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Threonine synthasePRO_0000185633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiO24924.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0098.

Structurei

3D structure databases

ProteinModelPortaliO24924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiILLWLES.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24924 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFVPTRSLK EKKIDFIEAI LNPNAPKGGL YTLERFETLQ WQDCLNLSYN
60 70 80 90 100
DLVECVFERL GLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL
110 120 130 140 150
YHGPSLAFKD MALQPLASLF SNLAVGKNEK YLMLVSTSGD TGPATLESLA
160 170 180 190 200
GMPNVFVVCL YPKDGTSLVQ KLQMVTQSAS NLKVFGISGD FDDAQNALKN
210 220 230 240 250
LLKDDDFNEA LKACQLKLSV ANSVNFGRIA FQIVYHIWGF LELYKKGAIN
260 270 280 290 300
SKEKITLAIP SGNFGNALGA FYAKKMGLNI DKIKVVTNSN DVLREFIETG
310 320 330 340 350
RYDLTHRSLK QTYSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF
360 370 380 390 400
YALKPKELAL LQEHFSCASC SDEACLKTIQ EVYAEHQYLI DPHTATALNA
410 420 430 440 450
SLKTHEKTLV SATASYEKFP RITLLALNEQ KKNDNDKAAL ETLKNSYNTP
460 470 480
DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLESLH
Length:486
Mass (Da):54,707
Last modified:January 1, 1998 - v1
Checksum:iCD9637799B508988
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07166.1.
PIRiB64532.
RefSeqiNP_206898.1. NC_000915.1.
YP_006934020.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07166; AAD07166; HP_0098.
GeneIDi13869276.
898925.
KEGGiheo:C694_00480.
hpy:HP0098.
PATRICi20591407. VBIHelPyl33062_0103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07166.1 .
PIRi B64532.
RefSeqi NP_206898.1. NC_000915.1.
YP_006934020.1. NC_018939.1.

3D structure databases

ProteinModelPortali O24924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0098.

Proteomic databases

PRIDEi O24924.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07166 ; AAD07166 ; HP_0098 .
GeneIDi 13869276.
898925.
KEGGi heo:C694_00480.
hpy:HP0098.
PATRICi 20591407. VBIHelPyl33062_0103.

Phylogenomic databases

eggNOGi COG0498.
KOi K01733.
OMAi ILLWLES.
OrthoDBi EOG65BDJX.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .
BioCyci HPY:HP0098-MONOMER.

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTHRC_HELPY
AccessioniPrimary (citable) accession number: O24924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3