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O24924

- THRC_HELPY

UniProt

O24924 - THRC_HELPY

Protein

Threonine synthase

Gene

thrC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHPY:HP0098-MONOMER.
    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:HP_0098
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Threonine synthasePRO_0000185633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei109 – 1091N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiO24924.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0098.

    Structurei

    3D structure databases

    ProteinModelPortaliO24924.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    KOiK01733.
    OMAiILLWLES.
    OrthoDBiEOG65BDJX.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O24924-1 [UniParc]FASTAAdd to Basket

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    MPFVPTRSLK EKKIDFIEAI LNPNAPKGGL YTLERFETLQ WQDCLNLSYN    50
    DLVECVFERL GLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL 100
    YHGPSLAFKD MALQPLASLF SNLAVGKNEK YLMLVSTSGD TGPATLESLA 150
    GMPNVFVVCL YPKDGTSLVQ KLQMVTQSAS NLKVFGISGD FDDAQNALKN 200
    LLKDDDFNEA LKACQLKLSV ANSVNFGRIA FQIVYHIWGF LELYKKGAIN 250
    SKEKITLAIP SGNFGNALGA FYAKKMGLNI DKIKVVTNSN DVLREFIETG 300
    RYDLTHRSLK QTYSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF 350
    YALKPKELAL LQEHFSCASC SDEACLKTIQ EVYAEHQYLI DPHTATALNA 400
    SLKTHEKTLV SATASYEKFP RITLLALNEQ KKNDNDKAAL ETLKNSYNTP 450
    DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLESLH 486
    Length:486
    Mass (Da):54,707
    Last modified:January 1, 1998 - v1
    Checksum:iCD9637799B508988
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07166.1.
    PIRiB64532.
    RefSeqiNP_206898.1. NC_000915.1.
    YP_006934020.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07166; AAD07166; HP_0098.
    GeneIDi13869276.
    898925.
    KEGGiheo:C694_00480.
    hpy:HP0098.
    PATRICi20591407. VBIHelPyl33062_0103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07166.1 .
    PIRi B64532.
    RefSeqi NP_206898.1. NC_000915.1.
    YP_006934020.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O24924.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0098.

    Proteomic databases

    PRIDEi O24924.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07166 ; AAD07166 ; HP_0098 .
    GeneIDi 13869276.
    898925.
    KEGGi heo:C694_00480.
    hpy:HP0098.
    PATRICi 20591407. VBIHelPyl33062_0103.

    Phylogenomic databases

    eggNOGi COG0498.
    KOi K01733.
    OMAi ILLWLES.
    OrthoDBi EOG65BDJX.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .
    BioCyci HPY:HP0098-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiTHRC_HELPY
    AccessioniPrimary (citable) accession number: O24924
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3