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Protein

Type-2 restriction enzyme

Gene

HP_0091

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
Biological processRestriction systemUniRule annotation

Enzyme and pathway databases

BioCyciHPY:HP0091-MONOMER

Protein family/group databases

REBASEi56862 Hpy26695ORF450P

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzymeUniRule annotation (EC:3.1.21.4UniRule annotation)
Gene namesi
Ordered Locus Names:HP_0091Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiO24917

Interactioni

Protein-protein interaction databases

IntActiO24917, 1 interactor
STRINGi85962.HP0091

Structurei

3D structure databases

ProteinModelPortaliO24917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 271DpnIIInterPro annotationAdd BLAST265

Sequence similaritiesi

Belongs to the type II restriction enzyme DpnII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41076U0 Bacteria
ENOG410YTH4 LUCA
KOiK01155
OMAiGLEQIFC

Family and domain databases

InterProiView protein in InterPro
IPR011335 Restrct_endonuc-II-like
IPR021191 Restrct_endonuc_II_DpmII
IPR007637 Restrct_endonuc_II_DpmII-like
PfamiView protein in Pfam
PF04556 DpnII, 1 hit
PIRSFiPIRSF016080 Restrict_endonuc_II_DpmII, 1 hit
SUPFAMiSSF52980 SSF52980, 1 hit

Sequencei

Sequence statusi: Complete.

O24917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNHLPFDIF LKSLKTSNRT LDFFTDWQKC LKNKNKISIA LNHLNFLLGK
60 70 80 90 100
DTKELKNCIK SLFKEYPKAF NVLNILIAVR DKKDIVLDAN GNFYPLYSYF
110 120 130 140 150
EDGEKVYEFI RQTGLERIFC NRNIKDLNDF VFGIEVGLDS NARKNRSGKV
160 170 180 190 200
MENHLSGLFT NAQLNFKEQV EIREFEDLCQ AFGDDIKKFD FVVCGKDKTY
210 220 230 240 250
FIEANFYTIS GSKLNEVARS YQDLALKFEA FPNYEFIWIT DGIGWLDAKN
260 270
KLQEAYKSVE IYNLSNVNDF ISKAQKW
Length:277
Mass (Da):32,398
Last modified:January 1, 1998 - v1
Checksum:i5D9AF14BF9DAA4E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07162.1
PIRiC64531
RefSeqiNP_206891.1, NC_000915.1
WP_000788527.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07162; AAD07162; HP_0091
GeneIDi900289
KEGGiheo:C694_00445
hpy:HP0091
PATRICifig|85962.47.peg.97

Similar proteinsi

Entry informationi

Entry nameiO24917_HELPY
AccessioniPrimary (citable) accession number: O24917
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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