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Protein

Malate:quinone oxidoreductase

Gene

mqo

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain.

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.

Cofactori

FADNote: The FAD is tightly bound.

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).
Proteins known to be involved in this subpathway in this organism are:
  1. Malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciHPY:HP0086-MONOMER
MetaCyc:HP0086-MONOMER
BRENDAi1.1.5.4 2604
UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Malate:quinone oxidoreductase (EC:1.1.5.4)
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene namesi
Name:mqo
Ordered Locus Names:HP_0086
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287171 – 450Malate:quinone oxidoreductaseAdd BLAST450

Proteomic databases

PaxDbiO24913

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0086

Structurei

3D structure databases

ProteinModelPortaliO24913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.Curated

Phylogenomic databases

eggNOGiENOG4107RSR Bacteria
COG0579 LUCA
KOiK00116
OMAiDMGEAKI

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

O24913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA
60 70 80 90 100
NSQTIHDGSI ETNYTPEKAK KVRLSAYKTR QYALNKGLQN EVIFETQKMA
110 120 130 140 150
IGVGDEECEF MKKRYESFKE IFVGLEEFDK QKIKELEPNV ILGANGIDRH
160 170 180 190 200
ENIIGHGYRK DWSTMNFAKL SENFVEEALK LKPNNQVFLN FKVKKIEKRN
210 220 230 240 250
DTYAVISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG CLPVAGSFYF
260 270 280 290 300
VPDLLRGKVY TVQNPKLPFA AVHGDPDAVI KGKTRIGPTA LTMPKLERNK
310 320 330 340 350
CWLKGISLEL LKMDLNKDVF KIAFDLMSDK EIRNYVFKNM VFELPIIGKR
360 370 380 390 400
KFLKDAQKII PSLSLEDLEY AHGFGEVRPQ VLDRTKRKLE LGEKKICTHK
410 420 430 440 450
GITFNMTPSP GATSCLQNAL VDSQEIAAYL GESFELERFY KDLSPEELEN
Length:450
Mass (Da):50,713
Last modified:January 1, 1998 - v1
Checksum:i5435E75D22E6E40B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07155.1
PIRiF64530
RefSeqiNP_206886.1, NC_000915.1
WP_000061441.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07155; AAD07155; HP_0086
GeneIDi899112
KEGGiheo:C694_00420
hpy:HP0086
PATRICifig|85962.47.peg.92

Similar proteinsi

Entry informationi

Entry nameiMQO_HELPY
AccessioniPrimary (citable) accession number: O24913
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health