Reviewed, UniProtKB/Swiss-Prot O24913 (MQO_HELPY)

Names and origin

Protein names

Recommended name:
    Malate:quinone oxidoreductase
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor]
    MQO

Gene names

Name:	mqo
Ordered Locus Names:	HP_0086

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain. HAMAP MF_00212
Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor. HAMAP MF_00212
Cofactor	FAD. The FAD is tightly bound. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00212
Subcellular location	Cell membrane; Peripheral membrane protein. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cell membrane Membrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Malate:quinone oxidoreductase HAMAP MF_00212		PRO_0000128717

Sequences

	Sequence		Length	Mass (Da)
	O24913-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 5435E75D22E6E40B	FASTA	450	50,713
	10 20 30 40 50 60 MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA NSQTIHDGSI 70 80 90 100 110 120 ETNYTPEKAK KVRLSAYKTR QYALNKGLQN EVIFETQKMA IGVGDEECEF MKKRYESFKE 130 140 150 160 170 180 IFVGLEEFDK QKIKELEPNV ILGANGIDRH ENIIGHGYRK DWSTMNFAKL SENFVEEALK 190 200 210 220 230 240 LKPNNQVFLN FKVKKIEKRN DTYAVISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG 250 260 270 280 290 300 CLPVAGSFYF VPDLLRGKVY TVQNPKLPFA AVHGDPDAVI KGKTRIGPTA LTMPKLERNK 310 320 330 340 350 360 CWLKGISLEL LKMDLNKDVF KIAFDLMSDK EIRNYVFKNM VFELPIIGKR KFLKDAQKII 370 380 390 400 410 420 PSLSLEDLEY AHGFGEVRPQ VLDRTKRKLE LGEKKICTHK GITFNMTPSP GATSCLQNAL 430 440 450 VDSQEIAAYL GESFELERFY KDLSPEELEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase." Kather B., Stingl K., van der Rest M.E., Altendorf K., Molenaar D. J. Bacteriol. 182:3204-3209(2000) [PubMed: 10809701] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 49503 / 60190.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07155.1.
PIR	F64530.
RefSeq	NP_206886.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	899112.
GenomeReviews	Gene locus HP_0086 in contig AE000511_GR.
KEGG	hpy:HP0086.
NMPDR	fig|85962.1.peg.84.
TIGR	HP_0086.
Phylogenomic databases
HOGENOM	O24913.
OMA	O24913. FELERFY.
Enzyme and pathway databases
BioCyc	MetaCyc:HP0086-MON.
BRENDA	1.1.99.16. 1131.
Family and domain databases
HAMAP	MF_00212. [Tree]
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MQO_HELPY

Accession

Primary (citable) accession number: O24913

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)