ID   O24911_HELPY            Unreviewed;       673 AA.
AC   O24911;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   SubName: Full=Methyl-accepting chemotaxis transducer (TlpC) {ECO:0000313|EMBL:AAD07152.1};
GN   OrderedLocusNames=HP_0082 {ECO:0000313|EMBL:AAD07152.1};
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07152.1, ECO:0000313|Proteomes:UP000000429};
RN   [1] {ECO:0000313|EMBL:AAD07152.1, ECO:0000313|Proteomes:UP000000429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA   Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA   Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA   Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA   Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA   Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2] {ECO:0007829|PDB:5WBF}
RP   X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 34-297 IN COMPLEX WITH
RP   (R)-LACTATE.
RX   PubMed=29075010; DOI=10.1038/s41598-017-14372-2;
RA   Machuca M.A., Johnson K.S., Liu Y.C., Steer D.L., Ottemann K.M.,
RA   Roujeinikova A.;
RT   "Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate.";
RL   Sci. Rep. 7:14089-14089(2017).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE000511; AAD07152.1; -; Genomic_DNA.
DR   PIR; B64530; B64530.
DR   RefSeq; NP_206882.1; NC_000915.1.
DR   RefSeq; WP_000843374.1; NC_018939.1.
DR   PDB; 5WBF; X-ray; 2.19 A; A/B/C=34-297.
DR   PDBsum; 5WBF; -.
DR   AlphaFoldDB; O24911; -.
DR   SMR; O24911; -.
DR   IntAct; O24911; 3.
DR   STRING; 85962.HP_0082; -.
DR   PaxDb; 85962-C694_00400; -.
DR   EnsemblBacteria; AAD07152; AAD07152; HP_0082.
DR   KEGG; hpy:HP_0082; -.
DR   PATRIC; fig|85962.47.peg.88; -.
DR   eggNOG; COG0840; Bacteria.
DR   InParanoid; O24911; -.
DR   OrthoDB; 5348717at2; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF112; HEME-BASED AEROTACTIC TRANSDUCER HEMAT; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:5WBF}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          453..673
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   BINDING         213
FT                   /ligand="(R)-lactate"
FT                   /ligand_id="ChEBI:CHEBI:16004"
FT                   /evidence="ECO:0007829|PDB:5WBF"
FT   BINDING         249
FT                   /ligand="(R)-lactate"
FT                   /ligand_id="ChEBI:CHEBI:16004"
FT                   /evidence="ECO:0007829|PDB:5WBF"
FT   BINDING         252
FT                   /ligand="(R)-lactate"
FT                   /ligand_id="ChEBI:CHEBI:16004"
FT                   /evidence="ECO:0007829|PDB:5WBF"
FT   BINDING         253
FT                   /ligand="(R)-lactate"
FT                   /ligand_id="ChEBI:CHEBI:16004"
FT                   /evidence="ECO:0007829|PDB:5WBF"
SQ   SEQUENCE   673 AA;  75214 MW;  A917EB43621B3EF6 CRC64;
     MKSTRIGSKI VMMVCAVVIV ISAVMGVIIS YKVESVLQSQ ATELLQKKAQ LVSFKIQGIM
     KRIFMGANTL EKFLSDENSA INDTLKRRML SEFLLANPHV LLVSAIYTNN NERVITAMSM
     DSKIAYPNTT LNENMTNQIR SLKSITHSDP YYKEVNGDKI YGMDITLPLM GKNQNAIGAL
     NFFLNIDAFY TDVVGKKKSN TFLMGKDGRL LINPNREIQD KILSAINPDR RVAKAVEYYN
     QNEAGTLSYH SLSGNTETFL AIQPFDFFEE KGNNGNHWRW AIGKYVNKSL VFKEATNTKF
     IIITTLILGV LVLAFLVFII VSNLITKRIS RVNNTLNDFF NLLNNPKNNH AISLTPPSAY
     DEIGQMQASI NENILKTQES IQADNKAIQN SIEVTNYVEN GDFTQEIACV PKNKDLQALR
     NTINSIIQYF RNQIGANIES LNNALEHYKN LDFTHHIQNP KANMEKALNT LGQEISSMLK
     ASLGFANALN HESKDLKTCV DNLTKTAHKQ ERSLKNTTQS LEEITNIITT IDSKSQEMIS
     QGEDIKSVVD MIRDIADQTN LLALNAAIEA ARAGEHGRGF AVVADEVRKL AERTQKSLSE
     IEANINILVQ SIADNAESIK MQNKGVENIH NSINALQQDV QDNLTIANHS LQVSTKIDGI
     SQDILEDVSR KKF
//