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Protein
Submitted name:

ATP-dependent C1p protease (ClpA)

Gene

HP_0033

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotationSAAS annotation, Hydrolase, ProteaseImported

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0033-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-dependent C1p protease (ClpA)Imported
Gene namesi
Ordered Locus Names:HP_0033Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiO24875.
PRIDEiO24875.

Interactioni

Protein-protein interaction databases

DIPiDIP-3404N.
IntActiO24875. 12 interactors.
MINTiMINT-178062.
STRINGi85962.HP0033.

Structurei

3D structure databases

ProteinModelPortaliO24875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 341AAAInterPro annotationAdd BLAST146
Domaini475 – 639AAAInterPro annotationAdd BLAST165
Domaini638 – 727ClpB_D2-smallInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the ClpA/ClpB family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
KOiK03694.
OMAiKEACYLI.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFNQDLNE VLNQALNLAL DLNHALCTTE HVLLVILEHE SGEKIIGTLE
60 70 80 90 100
RDDYDKLKQI LKDYLLQYVP LKSDPAKMPA RSFVLLRMLK RMYASCFESV
110 120 130 140 150
GVEELLILML DHPDCYASKL MDSFGIARLY SNPALLDLDN HGIPNDINDN
160 170 180 190 200
EEAPKNTPLK KYAKNLSALA QDNALDPVIG REEEILRVIE ILGRRKKNNP
210 220 230 240 250
LLIGEAGVGK TSIAEALALK IAQKEVPEFL QEYEVYSLDL ALMVAGAKYR
260 270 280 290 300
GDFEKRLKKT LKEIQQNGRI ILFIDEIHTL LGTGSSNAGS LDAANILKPV
310 320 330 340 350
LTDGSLKCLG ATTFEEYRSV FEKDKAFNRR FSVIKVEEPS KEACYLILKK
360 370 380 390 400
IAPLYEEHHQ VRYDESVFKA CVDLTSDYMH DKFLPDKAIE LLDEVGSRKK
410 420 430 440 450
ISPKKGKKIG VDDVKETLAL KLKIPKMRLS SDKKALLRNL EKSLKNKIFA
460 470 480 490 500
QAEAISLVSN AIKIQHCGLS AKNKPVGSFL FVGPSGVGKT ELAKELALNL
510 520 530 540 550
NLHFERFDMS EYKEAHSVAK LIGSPSGYVG FEQGGLLVNA IKKHPHCLLL
560 570 580 590 600
LDEIEKAHSN VYDLLLQVMD NATLSDNLGN QASFKHVILI MTSNVGSKDK
610 620 630 640 650
DTLGFFSAKN TKYDKAVKEL LTPELRSRID AIVPFNALSL EDFERIVSVE
660 670 680 690 700
LDKLKALALE QDITLKFHKE VVKFIAQKSY QTTLGAREIK KIIHNEIKTK
710 720 730 740
LSDILLLQSF KKPCKIACLL EKNQLVLKEI KRAQKVKEND F
Length:741
Mass (Da):83,254
Last modified:January 1, 1998 - v1
Checksum:iB26488DC06710195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07102.1.
PIRiA64524.
RefSeqiNP_206835.1. NC_000915.1.
WP_001051514.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07102; AAD07102; HP_0033.
GeneIDi899138.
KEGGiheo:C694_00155.
hpy:HP0033.
PATRICi20591265. VBIHelPyl33062_0034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07102.1.
PIRiA64524.
RefSeqiNP_206835.1. NC_000915.1.
WP_001051514.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO24875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3404N.
IntActiO24875. 12 interactors.
MINTiMINT-178062.
STRINGi85962.HP0033.

Proteomic databases

PaxDbiO24875.
PRIDEiO24875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07102; AAD07102; HP_0033.
GeneIDi899138.
KEGGiheo:C694_00155.
hpy:HP0033.
PATRICi20591265. VBIHelPyl33062_0034.

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
KOiK03694.
OMAiKEACYLI.

Enzyme and pathway databases

BioCyciHPY:HP0033-MONOMER.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO24875_HELPY
AccessioniPrimary (citable) accession number: O24875
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.