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O24782

- O24782_SPHPI

UniProt

O24782 - O24782_SPHPI

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Protein
Submitted name:

Fatty acid alpha-hydroxylase

Gene
N/A
Organism
Sphingomonas paucimobilis (Pseudomonas paucimobilis)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi361 – 3611Iron (heme axial ligand)Imported

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Ligandi

HemeImported, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid alpha-hydroxylaseImported
OrganismiSphingomonas paucimobilis (Pseudomonas paucimobilis)Imported
Taxonomic identifieri13689 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AWMX-ray1.65A1-415[»]
3AWPX-ray1.80A1-415[»]
3AWQX-ray1.90A1-415[»]
3VM4X-ray1.94A9-415[»]
3VNOX-ray2.17A9-415[»]
3VOOX-ray2.34A9-415[»]
3VTJX-ray2.56A1-415[»]
ProteinModelPortaliO24782.

Miscellaneous databases

EvolutionaryTraceiO24782.

Family & Domainsi

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

O24782-1 [UniParc]FASTAAdd to Basket

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MPKTPHTKGP DETLSLLADP YRFISRQCQR LGANAFESRF LLKKTNCLKG    50
AKAAEIFYDT TRFEREGAMP VAIQKTLLGQ GGVQGLDGET HRHRKQMFMG 100
LMTPERVRAL AQLFEAEWRR AVPGWTRKGE IVFYDELHEP LTRAVCAWAG 150
VPLPDDEAGN RAGELRALFD AAGSASPRHL WSRLARRRVD AWAKRIIEGI 200
RAGSIGSGSG TAAYAIAWHR DRHDDLLSPH VAAVELVNVL RPTVAIAVYI 250
TFVAHALQTC SGIRAALVQQ PDYAELFVQE VRRFYPFFPA VVARASQDFE 300
WEGMAFPEGR QVVLDLYGSN HDAATWADPQ EFRPERFRAW DEDSFNFIPQ 350
GGGDHYLGHR CPGEWIVLAI MKVAAHLLVN AMRYDVPDQD LSIDFARLPA 400
LPKSGFVMRN VHIGG 415
Length:415
Mass (Da):46,486
Last modified:January 1, 1998 - v1
Checksum:i3F0A1D488EF5A71E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006957 Genomic DNA. Translation: BAA22987.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006957 Genomic DNA. Translation: BAA22987.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AWM X-ray 1.65 A 1-415 [» ]
3AWP X-ray 1.80 A 1-415 [» ]
3AWQ X-ray 1.90 A 1-415 [» ]
3VM4 X-ray 1.94 A 9-415 [» ]
3VNO X-ray 2.17 A 9-415 [» ]
3VOO X-ray 2.34 A 9-415 [» ]
3VTJ X-ray 2.56 A 1-415 [» ]
ProteinModelPortali O24782.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei O24782.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
SUPFAMi SSF48264. SSF48264. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of fatty acid alpha-hydroxylase from Sphingomonas paucimobilis."
    Matsunaga I., Yokotani N., Gotoh O., Kusunose E., Yamada M., Ichihara K.
    J. Biol. Chem. 272:23592-23596(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: EY2395Imported.
  2. "Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position."
    Fujishiro T., Shoji O., Nagano S., Sugimoto H., Shiro Y., Watanabe Y.
    J. Biol. Chem. 286:29941-29950(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH HEME.
  3. "Chiral-substrate-assisted stereoselective epoxidation catalyzed by H2O2-dependent cytochrome P450SP?."
    Fujishiro T., Shoji O., Kawakami N., Watanabe T., Sugimoto H., Shiro Y., Watanabe Y.
    Chem Asian J 7:2286-2293(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 9-415 IN COMPLEX WITH HEME.
  4. "Crystal Structure of Hydrogen Peroxide-Dependent Cytochrome P450SP alpha mutants."
    Fujishiro T., Shoji O., Sugimoto H., Shiro Y., Watanabe Y.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 9-415 IN COMPLEX WITH HEME.
  5. "Crystal Structure of Hydrogen Peroxide-Dependent Cytochrome P450SP alpha mutants."
    Fujishiro T., Shoji O., Sugimoto H., Shiro Y., Watanabe Y.
    Submitted (MAY-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS) IN COMPLEX WITH HEME.

Entry informationi

Entry nameiO24782_SPHPI
AccessioniPrimary (citable) accession number: O24782
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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