Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanosine nucleotide diphosphate dissociation inhibitor 2

Gene

GDI2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • oxidoreductase activity Source: InterPro
  • Rab GDP-dissociation inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-ATH-194840. Rho GTPase cycle.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine nucleotide diphosphate dissociation inhibitor 2
Short name:
AtGDI2
Gene namesi
Name:GDI2
Ordered Locus Names:At3g59920
ORF Names:F24G16.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G59920.
TAIRilocus:2080527. AT3G59920.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cytosol Source: TAIR
  • plasmodesma Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004258081 – 444Guanosine nucleotide diphosphate dissociation inhibitor 2Add BLAST444

Proteomic databases

PaxDbiO24653.
PRIDEiO24653.

PTM databases

iPTMnetiO24653.

Expressioni

Tissue specificityi

Expressed in roots and floral buds.1 Publication

Gene expression databases

ExpressionAtlasiO24653. baseline and differential.
GenevisibleiO24653. AT.

Interactioni

Protein-protein interaction databases

BioGridi10476. 4 interactors.
IntActiO24653. 3 interactors.
STRINGi3702.AT3G59920.1.

Structurei

3D structure databases

ProteinModelPortaliO24653.
SMRiO24653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
HOGENOMiHOG000163825.
InParanoidiO24653.
KOiK17255.
OMAiGNTIDFI.
OrthoDBiEOG093608Q1.
PhylomeDBiO24653.

Family and domain databases

InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

O24653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEYEVIVL GTGLKECILS GLLSVDGVKV LHMDRNDYYG GESTSLNLNQ
60 70 80 90 100
LWKKFRGEEK APEHLGASRD YNVDMMPKFM MGNGKLVRTL IHTDVTKYLS
110 120 130 140 150
FKAVDGSYVF VKGKVQKVPA TPMEALKSSL MGIFEKRRAG KFFSFVQEYD
160 170 180 190 200
EKDPKTHDGM DLTRVTTKEL IAKYGLDGNT IDFIGHAVAL HTNDQHLDQP
210 220 230 240 250
AFDTVMRMKL YAESLARFQG TSPYIYPLYG LGELPQAFAR LSAVYGGTYM
260 270 280 290 300
LNKPECKVEF DEGGKVIGVT SEGETAKCKK IVCDPSYLPN KVRKIGRVAR
310 320 330 340 350
AIAIMSHPIP NTNDSHSVQV IIPQKQLARK SDMYVFCCSY SHNVAPKGKF
360 370 380 390 400
IAFVSTDAET DNPQTELKPG TDLLGPVDEI FFDMYDRYEP VNEPELDNCF
410 420 430 440
ISTSYDATTH FETTVADVLN MYTLITGKQL DLSVDLSAAS AAEE
Length:444
Mass (Da):49,539
Last modified:January 1, 1998 - v1
Checksum:i74DCD785558D9097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001397 mRNA. Translation: CAA04727.1.
AB005560 mRNA. Translation: BAA22504.1.
AL138647 Genomic DNA. Translation: CAB75811.1.
CP002686 Genomic DNA. Translation: AEE79985.1.
AY081269 mRNA. Translation: AAL91158.1.
BT000011 mRNA. Translation: AAN15330.1.
PIRiT47816.
RefSeqiNP_191551.1. NM_115855.4.
UniGeneiAt.23961.

Genome annotation databases

EnsemblPlantsiAT3G59920.1; AT3G59920.1; AT3G59920.
GeneIDi825162.
GrameneiAT3G59920.1; AT3G59920.1; AT3G59920.
KEGGiath:AT3G59920.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGDI2_ARATH
AccessioniPrimary (citable) accession number: O24653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families