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Protein

Putative receptor protein kinase CRINKLY4

Gene

CR4

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor protein kinase. Could play a role in a differentiation signal. The CRINKLY4 (CR4) mutation affects leaf epidermis differentiation such that cell size and morphology are altered, and surface functions are compromised, allowing graft-like fusions between organs.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei533ATPPROSITE-ProRule annotation1
Active sitei634Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi511 – 519ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative receptor protein kinase CRINKLY4 (EC:2.7.11.1)
Gene namesi
Name:CR4
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 10

Organism-specific databases

MaizeGDBi128723.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 423ExtracellularSequence analysisAdd BLAST399
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 901CytoplasmicSequence analysisAdd BLAST457

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002432025 – 901Putative receptor protein kinase CRINKLY4Add BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi338 ↔ 365PROSITE-ProRule annotation
Disulfide bondi368 ↔ 382PROSITE-ProRule annotation
Disulfide bondi372 ↔ 390PROSITE-ProRule annotation
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO24585.
PRIDEiO24585.

Expressioni

Gene expression databases

ExpressionAtlasiO24585. baseline and differential.
GenevisibleiO24585. ZM.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi4577.GRMZM2G051637_P01.

Structurei

3D structure databases

ProteinModelPortaliO24585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 681Add BLAST36
Repeati72 – 1072Add BLAST36
Repeati125 – 1603Add BLAST36
Repeati162 – 1954Add BLAST34
Repeati203 – 2365Add BLAST34
Repeati253 – 2876Add BLAST35
Repeati292 – 3307Add BLAST39
Repeati357 – 391TNFR-CysAdd BLAST35
Domaini505 – 712Protein kinasePROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 3307 X 36 AA repeatsAdd BLAST298

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF4A. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000029541.
OMAiGSHICLP.
OrthoDBiEOG093601OK.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR009091. RCC1/BLIP-II.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001368. TNFR/NGFR_Cys_rich_reg.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00020. TNFR_c6. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SM00208. TNFR. 1 hit.
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHVPALVLA GCCFLALLPG WACGLGSMSS IAVSYGEDGP VFCGLNSDGS
60 70 80 90 100
HLVACFGADA SVLYGAPPNI PFLGLTAGDG FVCGLLLDTR QPYCWGSNSY
110 120 130 140 150
VKSGVPQPMV EGARYSELSA GDNHLCALRA AQDGGRGSSA ATSLIDCWGY
160 170 180 190 200
NMTATHAVDE AVSTVSAGSV FNCGLFARNR TVFCWGDETV SGVVGLAPRD
210 220 230 240 250
LHFQSIGAGG YHVCGVLENA QVFCWGRSLE MQQVVPSSAI GDGDVNIVPM
260 270 280 290 300
DAMSTVVGGR FHACGIRSLD HQVACWGFTL HNSTSPPKGL KMYALVAGDY
310 320 330 340 350
FTCGVPAETS LMPRCWGNSG PLALPMAVPP GICVPTACSH GYYEYVNHGE
360 370 380 390 400
VGSIKVCKPA NSRLCLPCST GCPEGLYESS PCNATADRVC QFDCLKCVTD
410 420 430 440 450
ECLSFCLSQK RTKSRKLMAF QMRIFVAEIV FAVVLVLSVS VTTCLYVRHK
460 470 480 490 500
LRHCQCSNRE LRLAKSTAYS FRKDNMKIQP DMEDLKIRRA QEFSYEELEQ
510 520 530 540 550
ATGGFSEDSQ VGKGSFSCVF KGILRDGTVV AVKRAIKASD VKKSSKEFHN
560 570 580 590 600
ELDLLSRLNH AHLLNLLGYC EDGSERLLVY EFMAHGSLYQ HLHGKDPNLK
610 620 630 640 650
KRLNWARRVT IAVQAARGIE YLHGYACPPV IHRDIKSSNI LIDEDHNARV
660 670 680 690 700
ADFGLSILGP ADSGTPLSEL PAGTLGYLDP EYYRLHYLTT KSDVYSFGVV
710 720 730 740 750
LLEILSGRKA IDMQFEEGNI VEWAVPLIKA GDIFAILDPV LSPPSDLEAL
760 770 780 790 800
KKIASVACKC VRMRGKDRPS MDKVTTALEH ALALLMGSPC IEQPILPTEV
810 820 830 840 850
VLGSSRMHKV SQMSSNHSCS ENELADGEDQ GIGYRAPSWI TFPSVTSSQR
860 870 880 890 900
RKSSASEADI VGRRATDGRN VGSSIGDGLR SLEEEIAPAS PQENLYLQHN

F
Length:901
Mass (Da):97,439
Last modified:January 1, 1998 - v1
Checksum:i52F8481AC187E061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67422 mRNA. Translation: AAB09771.1.
PIRiT04108.
RefSeqiNP_001335655.1. NM_001348726.1.
UniGeneiZm.305.

Genome annotation databases

EnsemblPlantsiZm00001d023425_T001; Zm00001d023425_P001; Zm00001d023425.
GeneIDi542346.
GrameneiZm00001d023425_T001; Zm00001d023425_P001; Zm00001d023425.
KEGGizma:542346.

Similar proteinsi

Entry informationi

Entry nameiCRI4_MAIZE
AccessioniPrimary (citable) accession number: O24585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families