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Protein

Non-symbiotic hemoglobin 2

Gene

AHB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule. Has a low affinity for O2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi101 – 1011Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: TAIR

GO - Biological processi

  • fatty acid metabolic process Source: TAIR
  • triglyceride biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-symbiotic hemoglobin 2
Alternative name(s):
ARAth GLB2
Short name:
Hb2
Gene namesi
Name:AHB2
Synonyms:GLB2
Ordered Locus Names:At3g10520
ORF Names:F13M14.20, F18K10.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G10520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Non-symbiotic hemoglobin 2PRO_0000193012Add
BLAST

Proteomic databases

PaxDbiO24521.
PRIDEiO24521.

Expressioni

Tissue specificityi

Expressed in rosette leaves but not in roots.

Inductioni

By low temperature but not by low oxygen levels, dehydration, heat shock, wounding or oxidative stress.

Gene expression databases

ExpressionAtlasiO24521. baseline and differential.
GenevisibleiO24521. AT.

Interactioni

Subunit structurei

Unable to dimerize.Curated

Protein-protein interaction databases

STRINGi3702.AT3G10520.1.

Structurei

3D structure databases

ProteinModelPortaliO24521.
SMRiO24521. Positions 5-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plant globin family.Curated

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000233101.
InParanoidiO24521.
OMAiCETAIQL.
PhylomeDBiO24521.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEIGFTEKQ EALVKESWEI LKQDIPKYSL HFFSQILEIA PAAKGLFSFL
60 70 80 90 100
RDSDEVPHNN PKLKAHAVKV FKMTCETAIQ LREEGKVVVA DTTLQYLGSI
110 120 130 140 150
HLKSGVIDPH FEVVKEALLR TLKEGLGEKY NEEVEGAWSQ AYDHLALAIK

TEMKQEES
Length:158
Mass (Da):17,871
Last modified:January 1, 1998 - v1
Checksum:i9E3E145432E0BEA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94999 Genomic DNA. Translation: AAB82770.1.
AC011560 Genomic DNA. Translation: AAG51381.1.
AC013428 Genomic DNA. Translation: AAF76353.1.
CP002686 Genomic DNA. Translation: AEE74919.1.
AY087650 mRNA. Translation: AAM65188.1.
RefSeqiNP_187663.1. NM_111887.2.
UniGeneiAt.48644.

Genome annotation databases

EnsemblPlantsiAT3G10520.1; AT3G10520.1; AT3G10520.
GeneIDi820216.
GrameneiAT3G10520.1; AT3G10520.1; AT3G10520.
KEGGiath:AT3G10520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94999 Genomic DNA. Translation: AAB82770.1.
AC011560 Genomic DNA. Translation: AAG51381.1.
AC013428 Genomic DNA. Translation: AAF76353.1.
CP002686 Genomic DNA. Translation: AEE74919.1.
AY087650 mRNA. Translation: AAM65188.1.
RefSeqiNP_187663.1. NM_111887.2.
UniGeneiAt.48644.

3D structure databases

ProteinModelPortaliO24521.
SMRiO24521. Positions 5-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10520.1.

Proteomic databases

PaxDbiO24521.
PRIDEiO24521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10520.1; AT3G10520.1; AT3G10520.
GeneIDi820216.
GrameneiAT3G10520.1; AT3G10520.1; AT3G10520.
KEGGiath:AT3G10520.

Organism-specific databases

TAIRiAT3G10520.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000233101.
InParanoidiO24521.
OMAiCETAIQL.
PhylomeDBiO24521.

Miscellaneous databases

PROiO24521.

Gene expression databases

ExpressionAtlasiO24521. baseline and differential.
GenevisibleiO24521. AT.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two hemoglobin genes in Arabidopsis thaliana: the evolutionary origins of leghemoglobins."
    Trevaskis B., Watts R.A., Andersson C.R., Llewellyn D.J., Hargrove M.S., Olson J.S., Dennis E.S., Peacock W.J.
    Proc. Natl. Acad. Sci. U.S.A. 94:12230-12234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: cv. C24.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHBL2_ARATH
AccessioniPrimary (citable) accession number: O24521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.