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Protein

Non-symbiotic hemoglobin 1

Gene

AHB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule. Has an unusually high affinity for O2 because of a very low dissociation constant.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi104Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • oxygen binding Source: TAIR

GO - Biological processi

  • response to hypoxia Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-symbiotic hemoglobin 1
Alternative name(s):
ARAth GLB1
Short name:
Hb1
Gene namesi
Name:AHB1
Synonyms:GLB1
Ordered Locus Names:At2g16060
ORF Names:F7H1.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G16060.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • cytosol Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930111 – 160Non-symbiotic hemoglobin 1Add BLAST160

Proteomic databases

PaxDbiO24520.
PRIDEiO24520.

PTM databases

iPTMnetiO24520.
SwissPalmiO24520.

Expressioni

Tissue specificityi

Expressed in roots and rosette leaves.

Inductioni

By low oxygen levels but not by cold, dehydration, heat shock, wounding or oxidative stress.

Gene expression databases

ExpressionAtlasiO24520. baseline and differential.
GenevisibleiO24520. AT.

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi1462. 1 interactor.
STRINGi3702.AT2G16060.1.

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 24Combined sources14
Helixi25 – 27Combined sources3
Helixi28 – 42Combined sources15
Helixi44 – 49Combined sources6
Beta strandi50 – 57Combined sources8
Helixi60 – 62Combined sources3
Helixi66 – 87Combined sources22
Helixi94 – 106Combined sources13
Helixi111 – 128Combined sources18
Turni130 – 132Combined sources3
Helixi135 – 157Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHWX-ray2.22A/B1-160[»]
ProteinModelPortaliO24520.
SMRiO24520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plant globin family.Curated

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000233101.
InParanoidiO24520.
OMAiCEPHEDE.
OrthoDBiEOG09360PFS.
PhylomeDBiO24520.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEGKIVFT EEQEALVVKS WSVMKKNSAE LGLKLFIKIF EIAPTTKKMF
60 70 80 90 100
SFLRDSPIPA EQNPKLKPHA MSVFVMCCES AVQLRKTGKV TVRETTLKRL
110 120 130 140 150
GASHSKYGVV DEHFEVAKYA LLETIKEAVP EMWSPEMKVA WGQAYDHLVA
160
AIKAEMNLSN
Length:160
Mass (Da):18,034
Last modified:January 1, 1998 - v1
Checksum:i1C4C2170B0FA6F11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94998 Genomic DNA. Translation: AAB82769.1.
AC007134 Genomic DNA. Translation: AAD26949.1.
CP002685 Genomic DNA. Translation: AEC06463.1.
BT006405 mRNA. Translation: AAP21213.1.
PIRiC84536.
RefSeqiNP_179204.1. NM_127165.4.
UniGeneiAt.40321.

Genome annotation databases

EnsemblPlantsiAT2G16060.1; AT2G16060.1; AT2G16060.
GeneIDi816103.
GrameneiAT2G16060.1; AT2G16060.1; AT2G16060.
KEGGiath:AT2G16060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94998 Genomic DNA. Translation: AAB82769.1.
AC007134 Genomic DNA. Translation: AAD26949.1.
CP002685 Genomic DNA. Translation: AEC06463.1.
BT006405 mRNA. Translation: AAP21213.1.
PIRiC84536.
RefSeqiNP_179204.1. NM_127165.4.
UniGeneiAt.40321.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHWX-ray2.22A/B1-160[»]
ProteinModelPortaliO24520.
SMRiO24520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1462. 1 interactor.
STRINGi3702.AT2G16060.1.

PTM databases

iPTMnetiO24520.
SwissPalmiO24520.

Proteomic databases

PaxDbiO24520.
PRIDEiO24520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G16060.1; AT2G16060.1; AT2G16060.
GeneIDi816103.
GrameneiAT2G16060.1; AT2G16060.1; AT2G16060.
KEGGiath:AT2G16060.

Organism-specific databases

TAIRiAT2G16060.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000233101.
InParanoidiO24520.
OMAiCEPHEDE.
OrthoDBiEOG09360PFS.
PhylomeDBiO24520.

Miscellaneous databases

PROiO24520.

Gene expression databases

ExpressionAtlasiO24520. baseline and differential.
GenevisibleiO24520. AT.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBL1_ARATH
AccessioniPrimary (citable) accession number: O24520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.