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Protein

Non-symbiotic hemoglobin 1

Gene

AHB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule. Has an unusually high affinity for O2 because of a very low dissociation constant.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi104Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • oxygen binding Source: TAIR

GO - Biological processi

  • response to hypoxia Source: TAIR

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-symbiotic hemoglobin 1
Alternative name(s):
ARAth GLB1
Short name:
Hb1
Gene namesi
Name:AHB1
Synonyms:GLB1
Ordered Locus Names:At2g16060
ORF Names:F7H1.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G16060
TAIRilocus:2052981 AT2G16060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930111 – 160Non-symbiotic hemoglobin 1Add BLAST160

Proteomic databases

PaxDbiO24520
PRIDEiO24520

PTM databases

iPTMnetiO24520
SwissPalmiO24520

Expressioni

Tissue specificityi

Expressed in roots and rosette leaves.

Inductioni

By low oxygen levels but not by cold, dehydration, heat shock, wounding or oxidative stress.

Gene expression databases

ExpressionAtlasiO24520 baseline and differential
GenevisibleiO24520 AT

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi1462, 1 interactor
STRINGi3702.AT2G16060.1

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 24Combined sources14
Helixi25 – 27Combined sources3
Helixi28 – 42Combined sources15
Helixi44 – 49Combined sources6
Beta strandi50 – 57Combined sources8
Helixi60 – 62Combined sources3
Helixi66 – 87Combined sources22
Helixi94 – 106Combined sources13
Helixi111 – 128Combined sources18
Turni130 – 132Combined sources3
Helixi135 – 157Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHWX-ray2.22A/B1-160[»]
ProteinModelPortaliO24520
SMRiO24520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plant globin family.Curated

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOGENOMiHOG000233101
InParanoidiO24520
OMAiCCESAVQ
OrthoDBiEOG09360PFS
PhylomeDBiO24520

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR001032 Leghaemoglobin
IPR019824 Leghaemoglobin_Fe_BS
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00188 PLANTGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
PS00208 PLANT_GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

O24520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEGKIVFT EEQEALVVKS WSVMKKNSAE LGLKLFIKIF EIAPTTKKMF
60 70 80 90 100
SFLRDSPIPA EQNPKLKPHA MSVFVMCCES AVQLRKTGKV TVRETTLKRL
110 120 130 140 150
GASHSKYGVV DEHFEVAKYA LLETIKEAVP EMWSPEMKVA WGQAYDHLVA
160
AIKAEMNLSN
Length:160
Mass (Da):18,034
Last modified:January 1, 1998 - v1
Checksum:i1C4C2170B0FA6F11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94998 Genomic DNA Translation: AAB82769.1
AC007134 Genomic DNA Translation: AAD26949.1
CP002685 Genomic DNA Translation: AEC06463.1
BT006405 mRNA Translation: AAP21213.1
PIRiC84536
RefSeqiNP_179204.1, NM_127165.4
UniGeneiAt.40321

Genome annotation databases

EnsemblPlantsiAT2G16060.1; AT2G16060.1; AT2G16060
GeneIDi816103
GrameneiAT2G16060.1; AT2G16060.1; AT2G16060
KEGGiath:AT2G16060

Similar proteinsi

Entry informationi

Entry nameiHBL1_ARATH
AccessioniPrimary (citable) accession number: O24520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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